Security record
SYRE
Spyre Therapeutics, Inc. · Healthcare · Biotechnology
99Tracked holders
+22Δ holders
55.43MShares held
$4.93BReported value
+25New positions
−3Exits
Momentum inputs (comparable managers):
holder breadth +28.6% ·
share flow +30.0% ·
net new positions +20.0%
— formula
Broad accumulation — rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q2 2026
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 99 | +22 | 55.43M | $4.93B | +25 | −3 |
| Q1 2026 | 80 | +10 | 41.69M | $2.10B | +12 | −2 |
| Q4 2025 | 69 | +2 | 41.90M | $1.37B | +2 | — |
| Q3 2025 | 13 | -1 | 23.21M | $388.94M | +1 | −2 |
| Q2 2025 | 11 | 0 | 22.40M | $335.38M | +2 | −2 |
| Q1 2025 | 8 | -2 | 6.01M | $96.96M | — | −2 |
| Q4 2024 | 10 | +1 | 7.67M | $178.64M | +2 | −1 |
| Q3 2024 | 8 | 0 | 4.78M | $140.58M | +1 | −1 |
| Q2 2024 | 8 | — | 3.96M | $93.00M | — | — |
Who holds it · Q2 2026
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 13.03M | +10.6% | $1.16B | 0.1% | ▲ Add | 5 | SEC ↗ |
| 2 | Fidelity (FMR) ✦ | 13.03M | +10.6% | $1.16B | 0.1% | ▲ Add | 5 | SEC ↗ |
| 3 | Fidelity (FMR) ✦ | 13.03M | +10.6% | $1.16B | 0.1% | ▲ Add | 5 | SEC ↗ |
| 4 | Fidelity (FMR) ✦ | 13.03M | +10.6% | $1.16B | 0.1% | ▲ Add | 5 | SEC ↗ |
| 5 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 6 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 7 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 8 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 9 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 10 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 11 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 12 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 13 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 14 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 15 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 16 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 17 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 18 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 19 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 20 | Vanguard Capital Management Llc | 3.45M | +12.8% | $306.17M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 21 | State Street Global Advisors ✦ (passive) | 3.06M | +17.3% | $271.44M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 22 | T. Rowe Price ✦ | 2.96M | +85.2% | $262.87M | 0.0% | ▲ Add | 9 | SEC ↗ |
| 23 | T. Rowe Price ✦ | 2.96M | +85.2% | $262.87M | 0.0% | ▲ Add | 9 | SEC ↗ |
| 24 | Geode Capital Management ✦ (passive) | 2.56M | +48.9% | $239.26M | 0.0% | ▲ Add | 9 | SEC ↗ |
| 25 | Geode Capital Management ✦ (passive) | 2.56M | +48.9% | $239.26M | 0.0% | ▲ Add | 9 | SEC ↗ |
| 26 | Capital World Investors ✦ | 2.32M | +247.4% | $205.57M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 27 | Bank Of America Corp /De/ | 1.78M | +44.8% | $157.84M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 28 | Bank Of America Corp /De/ | 1.78M | +44.8% | $157.84M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 29 | Bank Of America Corp /De/ | 1.78M | +44.8% | $157.84M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 30 | Adage Capital Partners ✦ | 1.72M | New | $152.91M | 0.2% | New | 1 | SEC ↗ |
| 31 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 32 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 33 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 34 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 35 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 36 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 37 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 38 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 39 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ |
| 40 | Goldman Sachs Group ✦ | 1.48M | +447.6% | $131.22M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 41 | Goldman Sachs Group ✦ | 1.48M | +447.6% | $131.22M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 42 | Goldman Sachs Group ✦ | 1.48M | +447.6% | $131.22M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 43 | Goldman Sachs Group ✦ | 1.48M | +447.6% | $131.22M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 44 | Goldman Sachs Group ✦ | 1.48M | +447.6% | $131.22M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 45 | Goldman Sachs Group ✦ | 1.48M | +447.6% | $131.22M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 46 | Goldman Sachs Group ✦ | 1.48M | +447.6% | $131.22M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 47 | Franklin Resources Inc | 1.47M | +66.8% | $130.77M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 48 | Franklin Resources Inc | 1.47M | +66.8% | $130.77M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 49 | Franklin Resources Inc | 1.47M | +66.8% | $130.77M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 50 | Franklin Resources Inc | 1.47M | +66.8% | $130.77M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 51 | JPMorgan Chase ✦ | 1.09M | +11.6% | $98.87M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 52 | JPMorgan Chase ✦ | 1.09M | +11.6% | $98.87M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 53 | JPMorgan Chase ✦ | 1.09M | +11.6% | $98.87M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 54 | JPMorgan Chase ✦ | 1.09M | +11.6% | $98.87M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 55 | JPMorgan Chase ✦ | 1.09M | +11.6% | $98.87M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 56 | JPMorgan Chase ✦ | 1.09M | +11.6% | $98.87M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 57 | JPMorgan Chase ✦ | 1.09M | +11.6% | $98.87M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 58 | Holocene Advisors, LP | 1.02M | New | $90.13M | 0.2% | New | 1 | SEC ↗ |
| 59 | Marshall Wace ✦ | 991.69K | +612.1% | $88.04M | 0.1% | ▲ Add | 2 | SEC ↗ |
| 60 | Marshall Wace ✦ | 991.69K | +612.1% | $88.04M | 0.1% | ▲ Add | 2 | SEC ↗ |
| 61 | Marshall Wace ✦ | 991.69K | +612.1% | $88.04M | 0.1% | ▲ Add | 2 | SEC ↗ |
| 62 | Capital International Investors | 955.20K | -45.3% | $84.80M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 63 | UBS Group AG | 843.07K | +25.6% | $74.85M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 64 | UBS Group AG | 843.07K | +25.6% | $74.85M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 65 | UBS Group AG | 843.07K | +25.6% | $74.85M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 66 | UBS Group AG | 843.07K | +25.6% | $74.85M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 67 | Northern Trust Corp | 674.53K | +16.5% | $59.88M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 68 | Northern Trust Corp | 674.53K | +16.5% | $59.88M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 69 | Northern Trust Corp | 674.53K | +16.5% | $59.88M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 70 | Northern Trust Corp | 674.53K | +16.5% | $59.88M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 71 | Northern Trust Corp | 674.53K | +16.5% | $59.88M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 72 | Charles Schwab Investment… | 652.96K | +16.1% | $57.97M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 73 | Pictet Asset Management Holding SA | 628.14K | +27.8% | $55.77M | 0.1% | ▲ Add | 3 | SEC ↗ |
| 74 | Victory Capital Management Inc | 553.98K | +89.6% | $49.18M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 75 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 76 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 77 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 78 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 79 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 80 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 81 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 82 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 83 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 84 | Morgan Stanley ✦ | 499.96K | +102.6% | $44.39M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 85 | Morgan Stanley ✦ | 499.96K | +102.6% | $44.39M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 86 | Morgan Stanley ✦ | 499.96K | +102.6% | $44.39M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 87 | Morgan Stanley ✦ | 499.96K | +102.6% | $44.39M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 88 | Morgan Stanley ✦ | 499.96K | +102.6% | $44.39M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 89 | Morgan Stanley ✦ | 499.96K | +102.6% | $44.39M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 90 | Voya Investment Management Llc | 431.69K | +699.9% | $38.33M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 91 | Voya Investment Management Llc | 431.69K | +699.9% | $38.33M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 92 | Voya Investment Management Llc | 431.69K | +699.9% | $38.33M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 93 | Ameriprise Financial Inc | 356.08K | +123.7% | $31.61M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 94 | Ameriprise Financial Inc | 356.08K | +123.7% | $31.61M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 95 | Ameriprise Financial Inc | 356.08K | +123.7% | $31.61M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 96 | Jennison Associates Llc | 303.18K | New | $26.92M | 0.0% | New | 1 | SEC ↗ |
| 97 | Bnp Paribas Financial Markets | 259.92K | +1295.2% | $23.08M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 98 | Bank of New York Mellon Corp | 245.19K | +28.1% | $21.77M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 99 | Bank of New York Mellon Corp | 245.19K | +28.1% | $21.77M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 100 | Bank of New York Mellon Corp | 245.19K | +28.1% | $21.77M | 0.0% | ▲ Add | 3 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| Adage Capital Partners | $152.91M | 0.2% |
| Holocene Advisors, LP | $90.13M | 0.2% |
| Jennison Associates Llc | $26.92M | 0.0% |
Exited
| Assenagon Asset Management… | $940,555 | was 0.0% |
| Capstone Investment Advisors… | $380,166 | was 0.0% |
| Group One Trading Llc | $45,446 | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 197 holders, 82.12M shares, $4.06B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Aug 07
Albers Jeffrey W.
Director · 5.00K sh · $522,350
Aug 07
Albers Jeffrey W.
Director · 8.00K sh · $835,040
Aug 07
Albers Jeffrey W.
Director · 10.00K sh · $1.05M
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Aug 14
SC 13G/A — RTW INVESTMENTS, LP
Aug 14
SC 13G/A — PERCEPTIVE ADVISORS LLC
Jun 23
SC 13D/A — Fairmount Funds Management LLC
9.2% of class · View original SEC filing ↗
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q2 2026 ·
Methodology ·
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