Security record · archived quarter
GPCR
Structure Therapeutics Inc. · Healthcare · Biotechnology
71Tracked holders
0Δ holders
34.16MShares held
$2.38BReported value
+1New positions
−1Exits
Momentum inputs (comparable managers): holder breadth 0.0% · share flow +23.0% · net new positions 0.0% — formula
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 65 | 0 | 29.18M | $1.56B | +7 | −8 |
| Q1 2026 | 68 | -4 | 35.35M | $1.72B | +6 | −10 |
| Q4 2025 | 71 | 0 | 34.16M | $2.38B | +1 | −1 |
| Q3 2025 | 15 | 0 | 15.29M | $428.25M | +1 | −1 |
| Q2 2025 | 12 | 0 | 15.65M | $324.65M | — | — |
| Q1 2025 | 10 | +2 | 10.69M | $185.13M | +2 | — |
| Q4 2024 | 8 | -1 | 12.53M | $339.72M | — | −1 |
| Q3 2024 | 8 | -3 | 13.88M | $609.35M | — | −3 |
| Q2 2024 | 11 | — | 14.51M | $569.72M | — | — |
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 8.71M | +65.9% | $605.94M | 0.0% | ▲ Add | 3 | SEC ↗ ×6 |
| 2 | Wellington Management ✦ | 7.12M | +25.2% | $495.33M | 0.1% | ▲ Add | 7 | SEC ↗ ×8 |
| 3 | Janus Henderson Group Plc | 5.09M | — | $354.01M | 0.2% | n/c | 1 | SEC ↗ ×4 |
| 4 | Morgan Stanley ✦ | 2.09M | +261.4% | $145.21M | 0.0% | ▲ Add | 2 | SEC ↗ ×9 |
| 5 | T. Rowe Price ✦ | 1.67M | +477.5% | $116.23M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 6 | Principal Financial Group Inc | 1.28M | — | $89.32M | 0.0% | n/c | 1 | SEC ↗ |
| 7 | Franklin Resources Inc | 870.58K | — | $60.55M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 8 | Alliancebernstein L.P. | 848.85K | — | $59.04M | 0.0% | n/c | 1 | SEC ↗ |
| 9 | Deutsche Bank Ag\ | 841.16K | — | $58.50M | 0.0% | n/c | 1 | SEC ↗ |
| 10 | Citadel Advisors ✦ | 772.52K | +74.1% | $53.73M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 11 | American Century Companies Inc | 506.96K | — | $35.26M | 0.0% | n/c | 1 | SEC ↗ |
| 12 | Healthcare Of Ontario Pension Plan… | 467.80K | — | $32.54M | 0.1% | n/c | 1 | SEC ↗ |
| 13 | BlackRock ✦ (passive) | 430.08K | +63.0% | $29.91M | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 14 | Ameriprise Financial Inc | 285.52K | — | $19.86M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 15 | National Bank Of Canada /Fi/ | 265.40K | — | $18.46M | 0.0% | n/c | 1 | SEC ↗ |
| 16 | Aberdeen Group plc | 264.87K | — | $18.42M | 0.0% | n/c | 1 | SEC ↗ |
| 17 | Goldman Sachs Group ✦ | 224.33K | -55.5% | $15.60M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 18 | Balyasny Asset Management L.P. | 216.20K | — | $15.04M | 0.0% | n/c | 1 | SEC ↗ |
| 19 | UBS Group AG | 202.48K | — | $14.08M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 20 | Td Asset Management Inc | 174.67K | — | $12.15M | 0.0% | n/c | 1 | SEC ↗ |
| 21 | Marshall Wace ✦ | 168.58K | New | $11.73M | 0.0% | New | 1 | SEC ↗ ×3 |
| 22 | Millennium Management ✦ | 152.56K | -88.0% | $10.61M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 23 | Jane Street Group, Llc | 147.22K | — | $10.24M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 24 | Renaissance Technologies ✦ | 115.20K | -25.1% | $8.01M | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 25 | Alyeska Investment Group, L.P. | 115.00K | — | $8.00M | 0.0% | n/c | 1 | SEC ↗ |
| 26 | Two Sigma Investments ✦ | 95.54K | -47.8% | $6.65M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 27 | Manufacturers Life Insurance… | 96.39K | — | $6.53M | 0.0% | n/c | 1 | SEC ↗ |
| 28 | Simplex Trading, Llc | 92.67K | — | $6.45M | 0.2% | n/c | 1 | SEC ↗ |
| 29 | Universal- Beteiligungs- und… | 83.05K | — | $5.78M | 0.0% | n/c | 1 | SEC ↗ |
| 30 | Nomura Asset Management… | 82.64K | — | $5.75M | 0.0% | n/c | 1 | SEC ↗ |
| 31 | Osaic Holdings, Inc. | 59.24K | — | $4.12M | 0.0% | n/c | 1 | SEC ↗ |
| 32 | Voya Investment Management Llc | 55.30K | — | $3.85M | 0.0% | n/c | 1 | SEC ↗ |
| 33 | Geode Capital Management ✦ (passive) | 55.15K | -4.8% | $3.84M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 34 | Bank Of Montreal /Can/ | 54.34K | — | $3.68M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 35 | State Street Global Advisors ✦ (passive) | 48.22K | +4.8% | $3.35M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 36 | Raymond James Financial Inc | 44.39K | — | $3.09M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 37 | Mariner, LLC | 44.16K | — | $3.07M | 0.0% | n/c | 1 | SEC ↗ |
| 38 | Tudor Investment Corp Et Al | 35.05K | — | $2.44M | 0.0% | n/c | 1 | SEC ↗ |
| 39 | Bank Of America Corp /De/ | 31.68K | — | $2.20M | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 40 | Nomura Asset Management Co Ltd | 29.15K | — | $2.03M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 41 | Russell Investments Group, Ltd. | 26.27K | — | $1.83M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 42 | Peak6 Llc | 15.91K | — | $1.11M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 43 | Sei Investments Co | 14.90K | — | $1.04M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 44 | JPMorgan Chase ✦ | 12.96K | -88.9% | $901,090 | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 45 | Allianz Asset Management GmbH | 12.00K | — | $834,600 | 0.0% | n/c | 1 | SEC ↗ |
| 46 | Envestnet Asset Management Inc | 11.57K | — | $804,694 | 0.0% | n/c | 1 | SEC ↗ |
| 47 | Royal Bank Of Canada | 10.20K | — | $709,000 | 0.0% | n/c | 1 | SEC ↗ |
| 48 | HighTower Advisors, LLC | 9.32K | — | $648,206 | 0.0% | n/c | 1 | SEC ↗ |
| 49 | Susquehanna International Group, Llp | 9.00K | — | $625,880 | 0.0% | n/c | 1 | SEC ↗ |
| 50 | Bnp Paribas Financial Markets | 8.75K | — | $608,284 | 0.0% | n/c | 1 | SEC ↗ |
| 51 | D. E. Shaw & Co. ✦ | 8.62K | -76.3% | $599,730 | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 52 | LPL Financial LLC | 8.11K | — | $563,981 | 0.0% | n/c | 1 | SEC ↗ |
| 53 | Barclays Plc | 7.83K | — | $544,786 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 54 | Mml Investors Services, Llc | 7.83K | — | $544,229 | 0.0% | n/c | 1 | SEC ↗ |
| 55 | Citigroup Inc | 7.33K | — | $510,149 | 0.0% | n/c | 1 | SEC ↗ |
| 56 | Cetera Investment Advisers | 6.60K | — | $458,752 | 0.0% | n/c | 1 | SEC ↗ |
| 57 | Wells Fargo & Company/Mn | 5.66K | — | $393,896 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 58 | Mirae Asset Global Investments Co.… | 5.27K | — | $366,320 | 0.0% | n/c | 1 | SEC ↗ |
| 59 | Stifel Financial Corp | 4.83K | — | $335,932 | 0.0% | n/c | 1 | SEC ↗ |
| 60 | Pnc Financial Services Group, Inc. | 3.93K | — | $273,053 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 61 | Northern Trust Corp | 3.65K | — | $253,509 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 62 | Bank of New York Mellon Corp | 3.60K | — | $250,635 | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 63 | Cibc World Market Inc. | 3.25K | — | $225,898 | 0.0% | n/c | 1 | SEC ↗ |
| 64 | Invesco Ltd. | 3.20K | — | $222,560 | 0.0% | n/c | 1 | SEC ↗ |
| 65 | ProShare Advisors LLC | 2.96K | — | $205,659 | 0.0% | n/c | 1 | SEC ↗ |
| 66 | Assetmark, Inc | 2.10K | — | $145,707 | 0.0% | n/c | 1 | SEC ↗ |
| 67 | Jones Financial Companies Lllp | 1.05K | — | $72,749 | 0.0% | n/c | 1 | SEC ↗ |
| 68 | Rockefeller Capital Management L.P. | 731 | — | $50,841 | 0.0% | n/c | 1 | SEC ↗ |
| 69 | Cwm, Llc | 480 | — | $33,000 | 0.0% | n/c | 1 | SEC ↗ |
| 70 | Daiwa Securities Group Inc. | 186 | — | $13,000 | 0.0% | n/c | 1 | SEC ↗ |
| 71 | Northwestern Mutual Wealth… | 60 | — | $4,173 | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| Marshall Wace | $11.73M | 0.0% |
Exited
| Point72 Asset Management | $11.42M | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 1 holders, 118.22K shares, $5.19M reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Aug 06
SC 13G/A — FMR LLC
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
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