GPCR
Structure Therapeutics Inc. · Healthcare · Biotechnology
Momentum inputs (comparable managers): holder breadth 0.0% · share flow -9.2% · net new positions 0.0% — formula
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q3 2025
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 66 | 0 | 29.19M | $1.56B | +7 | −7 |
| Q1 2026 | 68 | -4 | 35.35M | $1.72B | +6 | −10 |
| Q4 2025 | 71 | 0 | 34.16M | $2.38B | +1 | −1 |
| Q3 2025 | 15 | 0 | 15.29M | $428.25M | +1 | −1 |
| Q2 2025 | 12 | 0 | 15.65M | $324.65M | — | — |
| Q1 2025 | 10 | +2 | 10.69M | $185.13M | +2 | — |
| Q4 2024 | 8 | -1 | 12.53M | $339.72M | — | −1 |
| Q3 2024 | 8 | -3 | 13.88M | $609.35M | — | −3 |
| Q2 2024 | 11 | — | 14.51M | $569.72M | — | — |
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Wellington Management ✦ | 5.69M | -17.3% | $159.30M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 2 | Wellington Management ✦ | 5.69M | -17.3% | $159.30M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 3 | Wellington Management ✦ | 5.69M | -17.3% | $159.30M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 4 | Wellington Management ✦ | 5.69M | -17.3% | $159.30M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 5 | Wellington Management ✦ | 5.69M | -17.3% | $159.30M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 6 | Wellington Management ✦ | 5.69M | -17.3% | $159.30M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 7 | Fidelity (FMR) ✦ | 5.25M | +6.8% | $147.01M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 8 | Fidelity (FMR) ✦ | 5.25M | +6.8% | $147.01M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 9 | Fidelity (FMR) ✦ | 5.25M | +6.8% | $147.01M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 10 | Fidelity (FMR) ✦ | 5.25M | +6.8% | $147.01M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 11 | Millennium Management ✦ | 1.27M | +4.5% | $35.69M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 12 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 13 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 14 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 15 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 16 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 17 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 18 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 19 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 20 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 21 | Morgan Stanley ✦ | 577.74K | — | $16.18M | 0.0% | n/c | 1 | SEC ↗ |
| 22 | Goldman Sachs Group ✦ | 504.40K | — | $14.12M | 0.0% | n/c | 1 | SEC ↗ |
| 23 | Citadel Advisors ✦ | 443.80K | -66.6% | $12.43M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 24 | Citadel Advisors ✦ | 443.80K | -66.6% | $12.43M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 25 | Point72 Asset Management ✦ | 407.70K | +23.6% | $11.42M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 26 | T. Rowe Price ✦ | 289.39K | -18.0% | $8.10M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 27 | BlackRock ✦ (passive) | 263.94K | +8.5% | $7.39M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 28 | BlackRock ✦ (passive) | 263.94K | +8.5% | $7.39M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 29 | BlackRock ✦ (passive) | 263.94K | +8.5% | $7.39M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 30 | Two Sigma Investments ✦ | 182.91K | New | $5.12M | 0.0% | New | 1 | SEC ↗ |
| 31 | Renaissance Technologies ✦ | 153.90K | +37.5% | $4.31M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 32 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 33 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 34 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 35 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 36 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 37 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 38 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 39 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 40 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 41 | JPMorgan Chase ✦ | 116.30K | — | $3.26M | 0.0% | n/c | 1 | SEC ↗ |
| 42 | Geode Capital Management ✦ (passive) | 57.96K | +7.0% | $1.62M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 43 | State Street Global Advisors ✦ (passive) | 46.02K | +37.5% | $1.29M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 44 | D. E. Shaw & Co. ✦ | 36.35K | +198.8% | $1.02M | 0.0% | ▲ Add | 3 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| Two Sigma Investments | $5.12M | 0.0% |
Exited
| Marshall Wace | $3.65M | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 1 holders, 118.22K shares, $5.19M reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.