Security record
SYRE
Spyre Therapeutics, Inc. · Healthcare · Biotechnology
99Tracked holders
+22Δ holders
55.44MShares held
$4.93BReported value
+25New positions
−3Exits
Momentum inputs (comparable managers):
holder breadth +28.6% ·
share flow +30.0% ·
net new positions +20.0%
— formula
Broad accumulation — rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q2 2026
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 99 | +22 | 55.44M | $4.93B | +25 | −3 |
| Q1 2026 | 80 | +10 | 41.69M | $2.10B | +12 | −2 |
| Q4 2025 | 69 | +2 | 41.90M | $1.37B | +2 | — |
| Q3 2025 | 13 | -1 | 23.21M | $388.94M | +1 | −2 |
| Q2 2025 | 11 | 0 | 22.40M | $335.38M | +2 | −2 |
| Q1 2025 | 8 | -2 | 6.01M | $96.96M | — | −2 |
| Q4 2024 | 10 | +1 | 7.67M | $178.64M | +2 | −1 |
| Q3 2024 | 8 | 0 | 4.78M | $140.58M | +1 | −1 |
| Q2 2024 | 8 | — | 3.96M | $93.00M | — | — |
Who holds it · Q2 2026
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 13.03M | +10.6% | $1.16B | 0.1% | ▲ Add | 5 | SEC ↗ ×4 |
| 2 | BlackRock ✦ (passive) | 6.51M | +17.9% | $577.66M | 0.0% | ▲ Add | 5 | SEC ↗ ×15 |
| 3 | Vanguard Capital Management Llc | 3.45M | +12.8% | $306.17M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 4 | State Street Global Advisors ✦ (passive) | 3.06M | +17.3% | $271.44M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 5 | T. Rowe Price ✦ | 2.96M | +85.2% | $262.87M | 0.0% | ▲ Add | 9 | SEC ↗ ×2 |
| 6 | Geode Capital Management ✦ (passive) | 2.56M | +48.9% | $239.26M | 0.0% | ▲ Add | 9 | SEC ↗ ×2 |
| 7 | Capital World Investors ✦ | 2.32M | +247.4% | $205.57M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 8 | Bank Of America Corp /De/ | 1.78M | +44.8% | $157.84M | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 9 | Adage Capital Partners ✦ | 1.72M | New | $152.91M | 0.2% | New | 1 | SEC ↗ |
| 10 | Wellington Management ✦ | 1.58M | -13.3% | $140.41M | 0.0% | ▼ Trim | 9 | SEC ↗ ×9 |
| 11 | Goldman Sachs Group ✦ | 1.48M | +447.6% | $131.22M | 0.0% | ▲ Add | 4 | SEC ↗ ×7 |
| 12 | Franklin Resources Inc | 1.47M | +66.8% | $130.77M | 0.0% | ▲ Add | 3 | SEC ↗ ×4 |
| 13 | JPMorgan Chase ✦ | 1.09M | +11.6% | $98.87M | 0.0% | ▲ Add | 4 | SEC ↗ ×7 |
| 14 | Holocene Advisors, LP | 1.02M | New | $90.13M | 0.2% | New | 1 | SEC ↗ |
| 15 | Marshall Wace ✦ | 991.69K | +612.1% | $88.04M | 0.1% | ▲ Add | 2 | SEC ↗ ×3 |
| 16 | Capital International Investors | 955.20K | -45.3% | $84.80M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 17 | UBS Group AG | 843.07K | +25.6% | $74.85M | 0.0% | ▲ Add | 3 | SEC ↗ ×4 |
| 18 | Northern Trust Corp | 674.53K | +16.5% | $59.88M | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 19 | Charles Schwab Investment… | 652.96K | +16.1% | $57.97M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 20 | Pictet Asset Management Holding SA | 628.14K | +27.8% | $55.77M | 0.1% | ▲ Add | 3 | SEC ↗ |
| 21 | Victory Capital Management Inc | 553.98K | +89.6% | $49.18M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 22 | UBS AM, a distinct business unit of… | 522.07K | +151.8% | $46.35M | 0.0% | ▲ Add | 3 | SEC ↗ ×9 |
| 23 | Morgan Stanley ✦ | 499.96K | +102.6% | $44.39M | 0.0% | ▲ Add | 4 | SEC ↗ ×6 |
| 24 | Voya Investment Management Llc | 431.69K | +699.9% | $38.33M | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 25 | Ameriprise Financial Inc | 356.08K | +123.7% | $31.61M | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 26 | Jennison Associates Llc | 303.18K | New | $26.92M | 0.0% | New | 1 | SEC ↗ |
| 27 | Bnp Paribas Financial Markets | 259.92K | +1295.2% | $23.08M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 28 | Bank of New York Mellon Corp | 245.19K | +28.1% | $21.77M | 0.0% | ▲ Add | 3 | SEC ↗ ×6 |
| 29 | Millennium Management ✦ | 196.71K | +34.1% | $17.46M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 30 | Nuveen, LLC | 181.10K | +17.7% | $16.08M | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 31 | Neuberger Berman Group LLC | 180.88K | New | $16.06M | 0.0% | New | 1 | SEC ↗ ×2 |
| 32 | Deutsche Bank Ag\ | 174.46K | +35.0% | $15.49M | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 33 | Universal- Beteiligungs- und… | 172.92K | +1.5% | $15.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 34 | Balyasny Asset Management L.P. | 147.04K | +165.1% | $13.05M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 35 | Squarepoint Ops LLC | 139.60K | New | $12.39M | 0.0% | New | 1 | SEC ↗ |
| 36 | Russell Investments Group, Ltd. | 134.76K | +1256.9% | $11.96M | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 37 | Ensign Peak Advisors, Inc | 126.62K | -14.8% | $11.24M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 38 | Invesco Ltd. | 120.54K | -8.9% | $10.70M | 0.0% | ▼ Trim | 3 | SEC ↗ ×4 |
| 39 | Td Asset Management Inc | 115.99K | -15.6% | $10.30M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 40 | Swiss National Bank | 112.50K | +16.6% | $9.99M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 41 | Manufacturers Life Insurance… | 104.52K | -7.4% | $9.28M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 42 | Citadel Advisors ✦ | 103.10K | -4.7% | $9.15M | 0.0% | ▼ Trim | 3 | SEC ↗ ×2 |
| 43 | Rhumbline Advisers | 94.76K | +11.3% | $8.41M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 44 | Barclays Plc | 94.07K | +105.5% | $8.35M | 0.0% | ▲ Add | 3 | SEC ↗ ×2 |
| 45 | Prudential Financial Inc | 87.37K | +46.7% | $7.76M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 46 | Federated Hermes, Inc. | 85.95K | New | $7.63M | 0.0% | New | 1 | SEC ↗ |
| 47 | Citigroup Inc | 82.59K | +587.9% | $7.33M | 0.0% | ▲ Add | 3 | SEC ↗ ×2 |
| 48 | Wells Fargo & Company/Mn | 82.51K | +148.4% | $7.32M | 0.0% | ▲ Add | 3 | SEC ↗ ×4 |
| 49 | Mercer Global Advisors Inc /Adv | 71.14K | +0.1% | $6.32M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 50 | Principal Financial Group Inc | 59.75K | +1289.8% | $5.30M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 51 | Raymond James Financial Inc | 53.63K | +171.5% | $4.76M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 52 | Alliancebernstein L.P. | 92.54K | +30.5% | $4.67M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 53 | Legal & General Group Plc | 49.14K | +9.7% | $4.36M | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 54 | Dimensional Fund Advisors Lp | 47.70K | 0.0% | $4.23M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 55 | Rockefeller Capital Management L.P. | 47.47K | -25.8% | $4.21M | 0.0% | ▼ Trim | 3 | SEC ↗ ×3 |
| 56 | Schroder Investment Management Group | 44.59K | -30.0% | $4.02M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 57 | State Of Wisconsin Investment Board | 45.03K | +69.8% | $4.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 58 | Nomura Asset Management… | 43.07K | New | $3.82M | 0.0% | New | 1 | SEC ↗ |
| 59 | Susquehanna International Group, Llp | 39.31K | +35.7% | $3.49M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 60 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 38.44K | +5.8% | $3.42M | 0.0% | ▲ Add | 3 | SEC ↗ ×2 |
| 61 | D. E. Shaw & Co. ✦ | 26.45K | New | $2.35M | 0.0% | New | 1 | SEC ↗ ×2 |
| 62 | New York State Common Retirement… | 26.16K | +17.5% | $2.32M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 63 | Zurcher Kantonalbank (Zurich… | 26.14K | +87.3% | $2.32M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 64 | Creative Planning | 25.71K | +66.0% | $2.28M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 65 | AQR Capital Management ✦ | 22.94K | +9.9% | $2.04M | 0.0% | ▲ Add | 5 | SEC ↗ ×6 |
| 66 | Osaic Holdings, Inc. | 18.15K | +3543.8% | $1.61M | 0.0% | ▲ Add | 3 | SEC ↗ ×2 |
| 67 | State Board Of Administration Of… | 18.08K | +30.0% | $1.60M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 68 | Fifth Third Bancorp | 15.64K | +312660.0% | $1.39M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 69 | Allianz Asset Management GmbH | 14.10K | New | $1.25M | 0.0% | New | 1 | SEC ↗ |
| 70 | Sei Investments Co | 13.94K | +55.3% | $1.24M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 71 | Brown Advisory Inc | 13.55K | +9.3% | $1.20M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 72 | Two Sigma Investments ✦ | 12.77K | New | $1.13M | 0.0% | New | 1 | SEC ↗ |
| 73 | ProShare Advisors LLC | 12.60K | -6.7% | $1.12M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 74 | Hrt Financial Lp | 10.00K | New | $887,000 | 0.0% | New | 1 | SEC ↗ |
| 75 | First Trust Advisors Lp | 9.78K | -94.5% | $868,179 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 76 | Man Group plc | 7.71K | -19.2% | $684,849 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 77 | Envestnet Asset Management Inc | 7.67K | New | $680,587 | 0.0% | New | 1 | SEC ↗ |
| 78 | Allspring Global Investments… | 6.09K | New | $541,340 | 0.0% | New | 1 | SEC ↗ ×2 |
| 79 | Quantinno Capital Management LP | 6.01K | +31.9% | $534,012 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 80 | Captrust Financial Advisors | 5.02K | New | $445,942 | 0.0% | New | 1 | SEC ↗ |
| 81 | Connor, Clark & Lunn Investment… | 4.80K | New | $426,233 | 0.0% | New | 1 | SEC ↗ |
| 82 | CIBC Bancorp USA Inc. | 4.12K | New | $365,951 | 0.0% | New | 1 | SEC ↗ ×3 |
| 83 | Mirae Asset Global Investments Co.… | 3.88K | -5.2% | $344,822 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 84 | Stifel Financial Corp | 3.01K | New | $267,316 | 0.0% | New | 1 | SEC ↗ ×2 |
| 85 | Jane Street Group, Llc | 2.91K | New | $258,261 | 0.0% | New | 1 | SEC ↗ ×2 |
| 86 | Tudor Investment Corp Et Al | 2.65K | -68.4% | $234,823 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 87 | CIBC Asset Management Inc | 2.43K | New | $215,647 | 0.0% | New | 1 | SEC ↗ |
| 88 | Royal Bank Of Canada | 2.34K | -28.1% | $208,000 | 0.0% | ▼ Trim | 3 | SEC ↗ ×3 |
| 89 | Mitsubishi UFJ Trust & Banking Corp | 1.84K | New | $163,710 | 0.0% | New | 1 | SEC ↗ |
| 90 | Us Bancorp \De\ | 1.51K | +1453.6% | $133,791 | 0.0% | ▲ Add | 3 | SEC ↗ ×2 |
| 91 | Pnc Financial Services Group, Inc. | 914 | +643.1% | $81,145 | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 92 | BNP Paribas Asset Management… | 897 | +1.0% | $79,636 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 93 | Pacer Advisors, Inc. | 614 | New | $55,000 | 0.0% | New | 1 | SEC ↗ |
| 94 | Optiver Holding B.V. | 400 | +38.9% | $35,512 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 95 | Simplex Trading, Llc | 278 | New | $24,680 | 0.0% | New | 1 | SEC ↗ |
| 96 | Toronto Dominion Bank | 270 | New | $23,971 | 0.0% | New | 1 | SEC ↗ |
| 97 | National Bank Of Canada /Fi/ | 124 | New | $11,006 | 0.0% | New | 1 | SEC ↗ |
| 98 | Jones Financial Companies Lllp | 103 | New | $9,053 | 0.0% | New | 1 | SEC ↗ |
| 99 | Nomura Asset Management Co Ltd | 0 | — | $0 | 0.0% | Held | 3 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| Adage Capital Partners | $152.91M | 0.2% |
| Holocene Advisors, LP | $90.13M | 0.2% |
| Jennison Associates Llc | $26.92M | 0.0% |
| Neuberger Berman Group LLC | $16.06M | 0.0% |
| Squarepoint Ops LLC | $12.39M | 0.0% |
| Federated Hermes, Inc. | $7.63M | 0.0% |
| Nomura Asset Management… | $3.82M | 0.0% |
| D. E. Shaw & Co. | $2.35M | 0.0% |
| Allianz Asset Management GmbH | $1.25M | 0.0% |
| Two Sigma Investments | $1.13M | 0.0% |
| Hrt Financial Lp | $887,000 | 0.0% |
| Envestnet Asset Management Inc | $680,587 | 0.0% |
Exited
| Assenagon Asset Management… | $940,555 | was 0.0% |
| Capstone Investment Advisors… | $380,166 | was 0.0% |
| Group One Trading Llc | $45,446 | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 197 holders, 82.12M shares, $4.06B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Oct 01
Burrows Scott L
Officer · 229 sh · $21,428
Oct 01
Burrows Scott L
Officer · 1.50K sh · $135,405
Oct 01
Burrows Scott L
Officer · 3.07K sh · $285,449
Oct 01
Burrows Scott L
Officer · 600 sh · $53,442
Oct 01
Burrows Scott L
Officer · 2.10K sh · $193,032
Sep 30
Burrows Scott L
Officer · 17.50K sh · $1.57M
Sep 02
Burrows Scott L
Officer · 18.23K sh · $1.63M
Sep 02
King-Jones Heidy
Officer · 400 sh · $36,000
Sep 01
King-Jones Heidy
Officer · 16.55K sh · $1.44M
Sep 01
Burrows Scott L
Officer · 900 sh · $77,625
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Oct 09
SC 13D/A — Fairmount Funds Management LLC
9.2% of class · View original SEC filing ↗
Oct 01
SC 13G — Paradigm Biocapital Advisors LP
Aug 14
SC 13G/A — RTW INVESTMENTS, LP
Aug 14
SC 13G/A — PERCEPTIVE ADVISORS LLC
Jun 23
SC 13D/A — Fairmount Funds Management LLC
9.2% of class · View original SEC filing ↗
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q2 2026 ·
Methodology ·
Get this via the API