证券记录 · 已归档季度
SYRE
Spyre Therapeutics, Inc. · Healthcare · Biotechnology
80被追踪持有人
+10Δ持有人
41.69M持有股份
$2.10B报告持仓市值
+12新建仓位
−2清仓
动量输入（同类管理人）：
持有人广度 +14.3% ·
股份流向 +1.7% ·
净新建仓位 +12.5%
· 公式
广泛增持：持股数量上升，持有人数量增加
所有持股数据：仅限已追踪的 13F 管理人，普通股持仓，报告期 Q1 2026
持股变化趋势
| 季度 | 持有人 | Δ | 股份 | 报告持仓市值 | 新增 | 清仓 |
|---|---|---|---|---|---|---|
| Q3 2026 | 2 | +2 | 602.45K | $53.61M | +2 | n/a |
| Q2 2026 | 99 | +22 | 55.44M | $4.93B | +25 | −3 |
| Q1 2026 | 80 | +10 | 41.69M | $2.10B | +12 | −2 |
| Q4 2025 | 69 | +2 | 41.90M | $1.37B | +2 | n/a |
| Q3 2025 | 13 | -1 | 23.21M | $388.94M | +1 | −2 |
| Q2 2025 | 11 | 0 | 22.40M | $335.38M | +2 | −2 |
| Q1 2025 | 8 | -2 | 6.01M | $96.96M | n/a | −2 |
| Q4 2024 | 10 | +1 | 7.67M | $178.64M | +2 | −1 |
| Q3 2024 | 8 | 0 | 4.78M | $140.58M | +1 | −1 |
| Q2 2024 | 8 | n/a | 3.96M | $93.00M | n/a | n/a |
持有人 · Q1 2026
| # | 管理人 | 股份 | Δ股份 | 价值 | 其权重 | 持有 | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 11.78M | +1.2% | $594.23M | 0.0% | ▲ Add | 4 | SEC ↗ ×3 |
| 2 | BlackRock ✦ (被动) | 5.52M | 0.0% | $278.49M | 0.0% | ▼ Trim | 4 | SEC ↗ ×13 |
| 3 | Vanguard Capital Management Llc | 3.06M | n/a | $154.22M | 0.0% | n/c | 1 | SEC ↗ |
| 4 | State Street Global Advisors ✦ (被动) | 2.61M | +15.2% | $131.50M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 5 | Wellington Management ✦ | 1.82M | +17.8% | $92.04M | 0.0% | ▲ Add | 8 | SEC ↗ ×8 |
| 6 | Capital International Investors | 1.75M | -50.0% | $88.07M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 7 | Geode Capital Management ✦ (被动) | 1.72M | +3.7% | $86.82M | 0.0% | ▲ Add | 8 | SEC ↗ ×2 |
| 8 | Janus Henderson Group Plc | 1.66M | -9.4% | $83.59M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 9 | T. Rowe Price ✦ | 1.60M | -0.2% | $80.64M | 0.0% | ▼ Trim | 8 | SEC ↗ ×2 |
| 10 | Bank Of America Corp /De/ | 1.23M | +192.6% | $61.95M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 11 | Franklin Resources Inc | 882.83K | -20.4% | $44.53M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 12 | JPMorgan Chase ✦ | 979.30K | +1455.7% | $44.48M | 0.0% | ▲ Add | 3 | SEC ↗ ×6 |
| 13 | UBS Group AG | 671.24K | -1.4% | $33.86M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 14 | Capital World Investors ✦ | 666.56K | +233.0% | $33.62M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 15 | Northern Trust Corp | 578.91K | +3.2% | $29.20M | 0.0% | ▲ Add | 2 | SEC ↗ ×5 |
| 16 | Charles Schwab Investment… | 562.65K | -2.1% | $28.38M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 17 | Pictet Asset Management Holding SA | 491.65K | -46.2% | $24.80M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 18 | Victory Capital Management Inc | 292.13K | +100.0% | $14.73M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 19 | Goldman Sachs Group ✦ | 269.94K | -1.9% | $13.62M | 0.0% | ▼ Trim | 3 | SEC ↗ ×2 |
| 20 | Morgan Stanley ✦ | 246.72K | +35.0% | $12.44M | 0.0% | ▲ Add | 3 | SEC ↗ ×6 |
| 21 | UBS AM, a distinct business unit of… | 207.31K | +233.2% | $10.46M | 0.0% | ▲ Add | 2 | SEC ↗ ×6 |
| 22 | Bank of New York Mellon Corp | 191.40K | -0.7% | $9.65M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 23 | First Trust Advisors Lp | 178.39K | 新增 | $9.00M | 0.0% | New | 1 | SEC ↗ |
| 24 | Universal- Beteiligungs- und… | 170.38K | -0.5% | $8.59M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 25 | Ameriprise Financial Inc | 159.22K | +316.2% | $8.03M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 26 | Nuveen, LLC | 153.90K | +1.9% | $7.76M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 27 | Ensign Peak Advisors, Inc | 148.54K | 新增 | $7.49M | 0.0% | New | 1 | SEC ↗ |
| 28 | Millennium Management ✦ | 146.64K | +92.5% | $7.40M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 29 | Marshall Wace ✦ | 139.26K | 新增 | $7.02M | 0.0% | New | 1 | SEC ↗ ×2 |
| 30 | Td Asset Management Inc | 137.39K | -8.3% | $6.93M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 31 | Invesco Ltd. | 132.39K | -12.3% | $6.68M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 32 | Deutsche Bank Ag\ | 129.24K | +6.0% | $6.52M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 33 | Manufacturers Life Insurance… | 112.84K | -12.5% | $5.69M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 34 | Citadel Advisors ✦ | 108.14K | +69.2% | $5.45M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 35 | Swiss National Bank | 96.50K | 0.0% | $4.87M | 0.0% | Held | 2 | SEC ↗ |
| 36 | Rhumbline Advisers | 85.12K | +2.6% | $4.29M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 37 | Mercer Global Advisors Inc /Adv | 71.09K | -33.1% | $3.59M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 38 | Rockefeller Capital Management L.P. | 64.00K | +11557.9% | $3.23M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 39 | Prudential Financial Inc | 59.55K | 新增 | $3.00M | 0.0% | New | 1 | SEC ↗ ×2 |
| 40 | California State Teachers… | 59.24K | +23.3% | $2.99M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 41 | Schroder Investment Management Group | 63.68K | n/a | $2.89M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 42 | Balyasny Asset Management L.P. | 55.48K | -24.5% | $2.80M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 43 | Voya Investment Management Llc | 53.97K | +97.9% | $2.72M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 44 | Dimensional Fund Advisors Lp | 47.70K | -38.3% | $2.41M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 45 | Alliancebernstein L.P. | 70.90K | +5.0% | $2.32M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 46 | Barclays Plc | 45.79K | -74.9% | $2.31M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 47 | Legal & General Group Plc | 44.79K | -20.6% | $2.26M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 48 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 36.32K | +3.4% | $1.81M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 49 | Wells Fargo & Company/Mn | 33.21K | -59.7% | $1.68M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 50 | Susquehanna International Group, Llp | 28.96K | +373.9% | $1.46M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 51 | State Of Wisconsin Investment Board | 26.52K | -2.7% | $1.34M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 52 | New York State Common Retirement… | 22.27K | +16.2% | $1.12M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 53 | AQR Capital Management ✦ | 20.87K | +17.1% | $1.05M | 0.0% | ▲ Add | 4 | SEC ↗ ×5 |
| 54 | Raymond James Financial Inc | 19.75K | 新增 | $996,442 | 0.0% | New | 1 | SEC ↗ ×3 |
| 55 | Assenagon Asset Management S.A. | 18.65K | -15.8% | $940,555 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 56 | Bnp Paribas Financial Markets | 18.63K | +57.3% | $939,697 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 57 | Creative Planning | 15.49K | 新增 | $781,114 | 0.0% | New | 1 | SEC ↗ |
| 58 | Zurcher Kantonalbank (Zurich… | 13.96K | +25.0% | $703,890 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 59 | State Board Of Administration Of… | 13.90K | +54.0% | $701,368 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 60 | ProShare Advisors LLC | 13.50K | -15.6% | $680,839 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 61 | Brown Advisory Inc | 12.40K | 新增 | $625,456 | 0.0% | New | 1 | SEC ↗ |
| 62 | Citigroup Inc | 12.01K | -88.0% | $605,583 | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 63 | Russell Investments Group, Ltd. | 9.93K | +78.8% | $500,918 | 0.0% | ▲ Add | 2 | SEC ↗ ×4 |
| 64 | Man Group plc | 9.55K | 新增 | $481,500 | 0.0% | New | 1 | SEC ↗ |
| 65 | Sei Investments Co | 8.97K | +46.7% | $452,699 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 66 | Tudor Investment Corp Et Al | 8.36K | -17.4% | $421,880 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 67 | Capstone Investment Advisors, Llc | 7.54K | 新增 | $380,166 | 0.0% | New | 1 | SEC ↗ |
| 68 | Quantinno Capital Management LP | 4.56K | 新增 | $230,057 | 0.0% | New | 1 | SEC ↗ |
| 69 | Principal Financial Group Inc | 4.30K | 新增 | $216,841 | 0.0% | New | 1 | SEC ↗ |
| 70 | Mirae Asset Global Investments Co.… | 4.10K | +8.7% | $206,653 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 71 | Royal Bank Of Canada | 3.25K | +63.5% | $164,000 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 72 | Cwm, Llc | 2.10K | +6.8% | $106,176 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 73 | Group One Trading Llc | 901 | +125.2% | $45,446 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 74 | BNP Paribas Asset Management… | 888 | +35.4% | $44,791 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 75 | Osaic Holdings, Inc. | 498 | +35.7% | $25,117 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 76 | Optiver Holding B.V. | 288 | +20.0% | $14,527 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 77 | Pnc Financial Services Group, Inc. | 123 | +43.0% | $6,204 | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 78 | Us Bancorp \De\ | 97 | +870.0% | $4,892 | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 79 | Fifth Third Bancorp | 5 | 新增 | $252 | 0.0% | New | 1 | SEC ↗ |
| 80 | Nomura Asset Management Co Ltd | 0 | n/a | $0 | 0.0% | Held | 2 | SEC ↗ |
"持仓权重"指该仓位占该管理人13F申报股票组合市值的比例，即持仓信心指标。✦ = 精选管理人。
新增买入方
| First Trust Advisors Lp | $9.00M | 0.0% |
| Ensign Peak Advisors, Inc | $7.49M | 0.0% |
| Marshall Wace | $7.02M | 0.0% |
| Prudential Financial Inc | $3.00M | 0.0% |
| Raymond James Financial Inc | $996,442 | 0.0% |
| Creative Planning | $781,114 | 0.0% |
| Brown Advisory Inc | $625,456 | 0.0% |
| Man Group plc | $481,500 | 0.0% |
| Capstone Investment Advisors… | $380,166 | 0.0% |
| Quantinno Capital Management… | $230,057 | 0.0% |
| Principal Financial Group Inc | $216,841 | 0.0% |
| Fifth Third Bancorp | $252 | 0.0% |
已清仓
| Point72 Asset Management | $21.70M | 曾为 0.0% |
| Daiwa Securities Group Inc. | $8,000 | 曾为 0.0% |
全市场背景: 涵盖所有13F申报机构（SEC结构化数据， Q1 2026): 197 持有人, 82.12M 股份, $4.06B 已申报. 这是与上方被追踪全域数据不同的较早期间，两者从不混用。
常见共同持仓
持有该证券的受追踪机构最常同时持有的其他证券：基于共同持有计数，而非基本面关联。
公开市场买入 (P)
在我们的覆盖窗口内无内部人士公开市场买入记录。
公开市场卖出 (S)
Oct 01
Burrows Scott L
Officer · 229 股 · $21,428
Oct 01
Burrows Scott L
Officer · 1.50K 股 · $135,405
Oct 01
Burrows Scott L
Officer · 3.07K 股 · $285,449
Oct 01
Burrows Scott L
Officer · 600 股 · $53,442
Oct 01
Burrows Scott L
Officer · 2.10K 股 · $193,032
Sep 30
Burrows Scott L
Officer · 17.50K 股 · $1.57M
Sep 02
Burrows Scott L
Officer · 18.23K 股 · $1.63M
Sep 02
King-Jones Heidy
Officer · 400 股 · $36,000
Sep 01
King-Jones Heidy
Officer · 16.55K 股 · $1.44M
Sep 01
Burrows Scott L
Officer · 900 股 · $77,625
授予、行权及税务代扣代缴在本平台均不计入买入或卖出。 方法论
Oct 09
SC 13D/A: Fairmount Funds Management LLC
9.2% 占股份类别 · 查看 SEC 原始申报文件 ↗
Oct 01
SC 13G: Paradigm Biocapital Advisors LP
Aug 14
SC 13G/A: RTW INVESTMENTS, LP
Aug 14
SC 13G/A: PERCEPTIVE ADVISORS LLC
Jun 23
SC 13D/A: Fairmount Funds Management LLC
9.2% 占股份类别 · 查看 SEC 原始申报文件 ↗
数据来源: 持股数据来源于已解析的13F普通股持仓（被追踪范围，变动对比集）；内部人行为来自Form 3/4/5；重大持股来自Schedule 13D/13G；所有文件均链接至SEC EDGAR原始申报。
报告期: Q1 2026 ·
方法论 ·
通过API获取此数据