Security record · archived quarter
SYRE
Spyre Therapeutics, Inc. · Healthcare · Biotechnology
80Tracked holders
+10Δ holders
41.69MShares held
$2.10BReported value
+12New positions
−2Exits
Momentum inputs (comparable managers):
holder breadth +14.3% ·
share flow +1.7% ·
net new positions +12.5%
· formula
Broad accumulation: rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q1 2026
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q3 2026 | 2 | +2 | 602.45K | $53.61M | +2 | n/a |
| Q2 2026 | 99 | +22 | 55.44M | $4.93B | +25 | −3 |
| Q1 2026 | 80 | +10 | 41.69M | $2.10B | +12 | −2 |
| Q4 2025 | 69 | +2 | 41.90M | $1.37B | +2 | n/a |
| Q3 2025 | 13 | -1 | 23.21M | $388.94M | +1 | −2 |
| Q2 2025 | 11 | 0 | 22.40M | $335.38M | +2 | −2 |
| Q1 2025 | 8 | -2 | 6.01M | $96.96M | n/a | −2 |
| Q4 2024 | 10 | +1 | 7.67M | $178.64M | +2 | −1 |
| Q3 2024 | 8 | 0 | 4.78M | $140.58M | +1 | −1 |
| Q2 2024 | 8 | n/a | 3.96M | $93.00M | n/a | n/a |
Who holds it · Q1 2026
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 11.78M | +1.2% | $594.23M | 0.0% | ▲ Add | 4 | SEC ↗ ×3 |
| 2 | BlackRock ✦ (passive) | 5.52M | 0.0% | $278.49M | 0.0% | ▼ Trim | 4 | SEC ↗ ×13 |
| 3 | Vanguard Capital Management Llc | 3.06M | n/a | $154.22M | 0.0% | n/c | 1 | SEC ↗ |
| 4 | State Street Global Advisors ✦ (passive) | 2.61M | +15.2% | $131.50M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 5 | Wellington Management ✦ | 1.82M | +17.8% | $92.04M | 0.0% | ▲ Add | 8 | SEC ↗ ×8 |
| 6 | Capital International Investors | 1.75M | -50.0% | $88.07M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 7 | Geode Capital Management ✦ (passive) | 1.72M | +3.7% | $86.82M | 0.0% | ▲ Add | 8 | SEC ↗ ×2 |
| 8 | Janus Henderson Group Plc | 1.66M | -9.4% | $83.59M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 9 | T. Rowe Price ✦ | 1.60M | -0.2% | $80.64M | 0.0% | ▼ Trim | 8 | SEC ↗ ×2 |
| 10 | Bank Of America Corp /De/ | 1.23M | +192.6% | $61.95M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 11 | Franklin Resources Inc | 882.83K | -20.4% | $44.53M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 12 | JPMorgan Chase ✦ | 979.30K | +1455.7% | $44.48M | 0.0% | ▲ Add | 3 | SEC ↗ ×6 |
| 13 | UBS Group AG | 671.24K | -1.4% | $33.86M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 14 | Capital World Investors ✦ | 666.56K | +233.0% | $33.62M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 15 | Northern Trust Corp | 578.91K | +3.2% | $29.20M | 0.0% | ▲ Add | 2 | SEC ↗ ×5 |
| 16 | Charles Schwab Investment… | 562.65K | -2.1% | $28.38M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 17 | Pictet Asset Management Holding SA | 491.65K | -46.2% | $24.80M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 18 | Victory Capital Management Inc | 292.13K | +100.0% | $14.73M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 19 | Goldman Sachs Group ✦ | 269.94K | -1.9% | $13.62M | 0.0% | ▼ Trim | 3 | SEC ↗ ×2 |
| 20 | Morgan Stanley ✦ | 246.72K | +35.0% | $12.44M | 0.0% | ▲ Add | 3 | SEC ↗ ×6 |
| 21 | UBS AM, a distinct business unit of… | 207.31K | +233.2% | $10.46M | 0.0% | ▲ Add | 2 | SEC ↗ ×6 |
| 22 | Bank of New York Mellon Corp | 191.40K | -0.7% | $9.65M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 23 | First Trust Advisors Lp | 178.39K | New | $9.00M | 0.0% | New | 1 | SEC ↗ |
| 24 | Universal- Beteiligungs- und… | 170.38K | -0.5% | $8.59M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 25 | Ameriprise Financial Inc | 159.22K | +316.2% | $8.03M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 26 | Nuveen, LLC | 153.90K | +1.9% | $7.76M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 27 | Ensign Peak Advisors, Inc | 148.54K | New | $7.49M | 0.0% | New | 1 | SEC ↗ |
| 28 | Millennium Management ✦ | 146.64K | +92.5% | $7.40M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 29 | Marshall Wace ✦ | 139.26K | New | $7.02M | 0.0% | New | 1 | SEC ↗ ×2 |
| 30 | Td Asset Management Inc | 137.39K | -8.3% | $6.93M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 31 | Invesco Ltd. | 132.39K | -12.3% | $6.68M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 32 | Deutsche Bank Ag\ | 129.24K | +6.0% | $6.52M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 33 | Manufacturers Life Insurance… | 112.84K | -12.5% | $5.69M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 34 | Citadel Advisors ✦ | 108.14K | +69.2% | $5.45M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 35 | Swiss National Bank | 96.50K | 0.0% | $4.87M | 0.0% | Held | 2 | SEC ↗ |
| 36 | Rhumbline Advisers | 85.12K | +2.6% | $4.29M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 37 | Mercer Global Advisors Inc /Adv | 71.09K | -33.1% | $3.59M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 38 | Rockefeller Capital Management L.P. | 64.00K | +11557.9% | $3.23M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 39 | Prudential Financial Inc | 59.55K | New | $3.00M | 0.0% | New | 1 | SEC ↗ ×2 |
| 40 | California State Teachers… | 59.24K | +23.3% | $2.99M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 41 | Schroder Investment Management Group | 63.68K | n/a | $2.89M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 42 | Balyasny Asset Management L.P. | 55.48K | -24.5% | $2.80M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 43 | Voya Investment Management Llc | 53.97K | +97.9% | $2.72M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 44 | Dimensional Fund Advisors Lp | 47.70K | -38.3% | $2.41M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 45 | Alliancebernstein L.P. | 70.90K | +5.0% | $2.32M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 46 | Barclays Plc | 45.79K | -74.9% | $2.31M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 47 | Legal & General Group Plc | 44.79K | -20.6% | $2.26M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 48 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 36.32K | +3.4% | $1.81M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 49 | Wells Fargo & Company/Mn | 33.21K | -59.7% | $1.68M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 50 | Susquehanna International Group, Llp | 28.96K | +373.9% | $1.46M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 51 | State Of Wisconsin Investment Board | 26.52K | -2.7% | $1.34M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 52 | New York State Common Retirement… | 22.27K | +16.2% | $1.12M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 53 | AQR Capital Management ✦ | 20.87K | +17.1% | $1.05M | 0.0% | ▲ Add | 4 | SEC ↗ ×5 |
| 54 | Raymond James Financial Inc | 19.75K | New | $996,442 | 0.0% | New | 1 | SEC ↗ ×3 |
| 55 | Assenagon Asset Management S.A. | 18.65K | -15.8% | $940,555 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 56 | Bnp Paribas Financial Markets | 18.63K | +57.3% | $939,697 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 57 | Creative Planning | 15.49K | New | $781,114 | 0.0% | New | 1 | SEC ↗ |
| 58 | Zurcher Kantonalbank (Zurich… | 13.96K | +25.0% | $703,890 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 59 | State Board Of Administration Of… | 13.90K | +54.0% | $701,368 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 60 | ProShare Advisors LLC | 13.50K | -15.6% | $680,839 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 61 | Brown Advisory Inc | 12.40K | New | $625,456 | 0.0% | New | 1 | SEC ↗ |
| 62 | Citigroup Inc | 12.01K | -88.0% | $605,583 | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 63 | Russell Investments Group, Ltd. | 9.93K | +78.8% | $500,918 | 0.0% | ▲ Add | 2 | SEC ↗ ×4 |
| 64 | Man Group plc | 9.55K | New | $481,500 | 0.0% | New | 1 | SEC ↗ |
| 65 | Sei Investments Co | 8.97K | +46.7% | $452,699 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 66 | Tudor Investment Corp Et Al | 8.36K | -17.4% | $421,880 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 67 | Capstone Investment Advisors, Llc | 7.54K | New | $380,166 | 0.0% | New | 1 | SEC ↗ |
| 68 | Quantinno Capital Management LP | 4.56K | New | $230,057 | 0.0% | New | 1 | SEC ↗ |
| 69 | Principal Financial Group Inc | 4.30K | New | $216,841 | 0.0% | New | 1 | SEC ↗ |
| 70 | Mirae Asset Global Investments Co.… | 4.10K | +8.7% | $206,653 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 71 | Royal Bank Of Canada | 3.25K | +63.5% | $164,000 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 72 | Cwm, Llc | 2.10K | +6.8% | $106,176 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 73 | Group One Trading Llc | 901 | +125.2% | $45,446 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 74 | BNP Paribas Asset Management… | 888 | +35.4% | $44,791 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 75 | Osaic Holdings, Inc. | 498 | +35.7% | $25,117 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 76 | Optiver Holding B.V. | 288 | +20.0% | $14,527 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 77 | Pnc Financial Services Group, Inc. | 123 | +43.0% | $6,204 | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 78 | Us Bancorp \De\ | 97 | +870.0% | $4,892 | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 79 | Fifth Third Bancorp | 5 | New | $252 | 0.0% | New | 1 | SEC ↗ |
| 80 | Nomura Asset Management Co Ltd | 0 | n/a | $0 | 0.0% | Held | 2 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| First Trust Advisors Lp | $9.00M | 0.0% |
| Ensign Peak Advisors, Inc | $7.49M | 0.0% |
| Marshall Wace | $7.02M | 0.0% |
| Prudential Financial Inc | $3.00M | 0.0% |
| Raymond James Financial Inc | $996,442 | 0.0% |
| Creative Planning | $781,114 | 0.0% |
| Brown Advisory Inc | $625,456 | 0.0% |
| Man Group plc | $481,500 | 0.0% |
| Capstone Investment Advisors… | $380,166 | 0.0% |
| Quantinno Capital Management… | $230,057 | 0.0% |
| Principal Financial Group Inc | $216,841 | 0.0% |
| Fifth Third Bancorp | $252 | 0.0% |
Exited
| Point72 Asset Management | $21.70M | was 0.0% |
| Daiwa Securities Group Inc. | $8,000 | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 197 holders, 82.12M shares, $4.06B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Oct 01
Burrows Scott L
Officer · 229 sh · $21,428
Oct 01
Burrows Scott L
Officer · 1.50K sh · $135,405
Oct 01
Burrows Scott L
Officer · 3.07K sh · $285,449
Oct 01
Burrows Scott L
Officer · 600 sh · $53,442
Oct 01
Burrows Scott L
Officer · 2.10K sh · $193,032
Sep 30
Burrows Scott L
Officer · 17.50K sh · $1.57M
Sep 02
Burrows Scott L
Officer · 18.23K sh · $1.63M
Sep 02
King-Jones Heidy
Officer · 400 sh · $36,000
Sep 01
King-Jones Heidy
Officer · 16.55K sh · $1.44M
Sep 01
Burrows Scott L
Officer · 900 sh · $77,625
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Oct 09
SC 13D/A: Fairmount Funds Management LLC
9.2% of class · View original SEC filing ↗
Oct 01
SC 13G: Paradigm Biocapital Advisors LP
Aug 14
SC 13G/A: RTW INVESTMENTS, LP
Aug 14
SC 13G/A: PERCEPTIVE ADVISORS LLC
Jun 23
SC 13D/A: Fairmount Funds Management LLC
9.2% of class · View original SEC filing ↗
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q1 2026 ·
Methodology ·
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