Security record · archived quarter
SYRE
Spyre Therapeutics, Inc. · Healthcare · Biotechnology
69Tracked holders
+2Δ holders
41.90MShares held
$1.37BReported value
+2New positions
−0Exits
Momentum inputs (comparable managers):
holder breadth +3.0% ·
share flow +18.7% ·
net new positions +2.9%
· formula
Broad accumulation: rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q3 2026 | 2 | +2 | 602.45K | $53.61M | +2 | n/a |
| Q2 2026 | 99 | +22 | 55.44M | $4.93B | +25 | −3 |
| Q1 2026 | 80 | +10 | 41.69M | $2.10B | +12 | −2 |
| Q4 2025 | 69 | +2 | 41.90M | $1.37B | +2 | n/a |
| Q3 2025 | 13 | -1 | 23.21M | $388.94M | +1 | −2 |
| Q2 2025 | 11 | 0 | 22.40M | $335.38M | +2 | −2 |
| Q1 2025 | 8 | -2 | 6.01M | $96.96M | n/a | −2 |
| Q4 2024 | 10 | +1 | 7.67M | $178.64M | +2 | −1 |
| Q3 2024 | 8 | 0 | 4.78M | $140.58M | +1 | −1 |
| Q2 2024 | 8 | n/a | 3.96M | $93.00M | n/a | n/a |
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 11.64M | +28.5% | $381.29M | 0.0% | ▲ Add | 3 | SEC ↗ ×3 |
| 2 | BlackRock ✦ (passive) | 5.52M | +38.6% | $180.90M | 0.0% | ▲ Add | 3 | SEC ↗ ×12 |
| 3 | The Vanguard Group ✦ (passive) | 4.04M | +32.3% | $132.19M | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 4 | Capital International Investors | 3.49M | n/a | $114.42M | 0.0% | n/c | 1 | SEC ↗ |
| 5 | State Street Global Advisors ✦ (passive) | 2.26M | +26.8% | $74.13M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 6 | Janus Henderson Group Plc | 1.83M | n/a | $59.92M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 7 | Geode Capital Management ✦ (passive) | 1.66M | +35.4% | $54.36M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 8 | T. Rowe Price ✦ | 1.60M | +158.1% | $52.48M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 9 | Wellington Management ✦ | 1.55M | -5.5% | $50.75M | 0.0% | ▼ Trim | 7 | SEC ↗ ×7 |
| 10 | Franklin Resources Inc | 1.11M | n/a | $36.34M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 11 | Pictet Asset Management Holding SA | 913.96K | n/a | $29.94M | 0.0% | n/c | 1 | SEC ↗ |
| 12 | UBS Group AG | 680.57K | n/a | $22.30M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 13 | Point72 Asset Management ✦ | 662.35K | New | $21.70M | 0.0% | New | 1 | SEC ↗ |
| 14 | Charles Schwab Investment… | 574.62K | n/a | $18.82M | 0.0% | n/c | 1 | SEC ↗ |
| 15 | Northern Trust Corp | 561.02K | n/a | $18.38M | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 16 | Bank Of America Corp /De/ | 419.73K | n/a | $13.75M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 17 | Goldman Sachs Group ✦ | 275.06K | -16.5% | $9.01M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 18 | Capital World Investors ✦ | 200.17K | 0.0% | $6.56M | 0.0% | Held | 5 | SEC ↗ |
| 19 | Bank of New York Mellon Corp | 192.83K | n/a | $6.32M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 20 | Morgan Stanley ✦ | 182.73K | -45.4% | $5.99M | 0.0% | ▼ Trim | 2 | SEC ↗ ×6 |
| 21 | Barclays Plc | 182.52K | n/a | $5.98M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 22 | Universal- Beteiligungs- und… | 171.21K | n/a | $5.61M | 0.0% | n/c | 1 | SEC ↗ |
| 23 | Nuveen, LLC | 150.98K | n/a | $4.95M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 24 | Invesco Ltd. | 150.93K | n/a | $4.94M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 25 | Td Asset Management Inc | 149.82K | n/a | $4.91M | 0.0% | n/c | 1 | SEC ↗ |
| 26 | Victory Capital Management Inc | 146.08K | n/a | $4.79M | 0.0% | n/c | 1 | SEC ↗ |
| 27 | Manufacturers Life Insurance… | 129.01K | n/a | $4.14M | 0.0% | n/c | 1 | SEC ↗ |
| 28 | Deutsche Bank Ag\ | 121.94K | n/a | $3.99M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 29 | Mercer Global Advisors Inc /Adv | 106.32K | n/a | $3.48M | 0.0% | n/c | 1 | SEC ↗ |
| 30 | Citigroup Inc | 100.06K | n/a | $3.28M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 31 | Swiss National Bank | 96.50K | n/a | $3.16M | 0.0% | n/c | 1 | SEC ↗ |
| 32 | Rhumbline Advisers | 82.96K | n/a | $2.72M | 0.0% | n/c | 1 | SEC ↗ |
| 33 | Wells Fargo & Company/Mn | 82.42K | n/a | $2.70M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 34 | Dimensional Fund Advisors Lp | 77.29K | n/a | $2.53M | 0.0% | n/c | 1 | SEC ↗ |
| 35 | Millennium Management ✦ | 76.19K | -81.3% | $2.50M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 36 | Balyasny Asset Management L.P. | 73.47K | n/a | $2.41M | 0.0% | n/c | 1 | SEC ↗ |
| 37 | Alliancebernstein L.P. | 67.50K | n/a | $2.21M | 0.0% | n/c | 1 | SEC ↗ |
| 38 | Citadel Advisors ✦ | 63.90K | New | $2.09M | 0.0% | New | 1 | SEC ↗ |
| 39 | JPMorgan Chase ✦ | 62.95K | -88.6% | $2.06M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 40 | UBS AM, a distinct business unit of… | 62.22K | n/a | $2.04M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 41 | Legal & General Group Plc | 56.45K | n/a | $1.85M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 42 | California State Teachers… | 48.04K | n/a | $1.57M | 0.0% | n/c | 1 | SEC ↗ |
| 43 | Ameriprise Financial Inc | 38.26K | n/a | $1.25M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 44 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 35.14K | n/a | $1.15M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 45 | Voya Investment Management Llc | 27.28K | n/a | $893,594 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 46 | State Of Wisconsin Investment Board | 27.25K | n/a | $892,776 | 0.0% | n/c | 1 | SEC ↗ |
| 47 | Assenagon Asset Management S.A. | 22.14K | n/a | $725,175 | 0.0% | n/c | 1 | SEC ↗ |
| 48 | New York State Common Retirement… | 19.16K | n/a | $627,845 | 0.0% | n/c | 1 | SEC ↗ |
| 49 | AQR Capital Management ✦ | 17.82K | +4.5% | $583,783 | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 50 | ProShare Advisors LLC | 15.99K | n/a | $523,801 | 0.0% | n/c | 1 | SEC ↗ |
| 51 | Bnp Paribas Financial Markets | 11.84K | n/a | $388,009 | 0.0% | n/c | 1 | SEC ↗ |
| 52 | Zurcher Kantonalbank (Zurich… | 11.16K | n/a | $365,733 | 0.0% | n/c | 1 | SEC ↗ |
| 53 | Tudor Investment Corp Et Al | 10.13K | n/a | $331,761 | 0.0% | n/c | 1 | SEC ↗ |
| 54 | State Board Of Administration Of… | 9.03K | n/a | $295,823 | 0.0% | n/c | 1 | SEC ↗ |
| 55 | Sei Investments Co | 6.12K | n/a | $200,393 | 0.0% | n/c | 1 | SEC ↗ |
| 56 | Susquehanna International Group, Llp | 6.11K | n/a | $200,196 | 0.0% | n/c | 1 | SEC ↗ |
| 57 | Russell Investments Group, Ltd. | 5.55K | n/a | $181,948 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 58 | Mirae Asset Global Investments Co.… | 3.77K | n/a | $123,505 | 0.0% | n/c | 1 | SEC ↗ |
| 59 | Cwm, Llc | 1.97K | n/a | $65,000 | 0.0% | n/c | 1 | SEC ↗ |
| 60 | Royal Bank Of Canada | 1.99K | n/a | $65,000 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 61 | BNP Paribas Asset Management… | 656 | n/a | $21,000 | 0.0% | n/c | 1 | SEC ↗ |
| 62 | Rockefeller Capital Management L.P. | 549 | n/a | $17,985 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 63 | Group One Trading Llc | 400 | n/a | $13,104 | 0.0% | n/c | 1 | SEC ↗ |
| 64 | Osaic Holdings, Inc. | 367 | n/a | $12,022 | 0.0% | n/c | 1 | SEC ↗ |
| 65 | Daiwa Securities Group Inc. | 258 | n/a | $8,000 | 0.0% | n/c | 1 | SEC ↗ |
| 66 | Optiver Holding B.V. | 240 | n/a | $7,862 | 0.0% | n/c | 1 | SEC ↗ |
| 67 | Pnc Financial Services Group, Inc. | 86 | n/a | $2,818 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 68 | Us Bancorp \De\ | 10 | n/a | $328 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 69 | Nomura Asset Management Co Ltd | 0 | n/a | $0 | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| Point72 Asset Management | $21.70M | 0.0% |
| Citadel Advisors | $2.09M | 0.0% |
Exited
| No tracked exits this quarter. |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 197 holders, 82.12M shares, $4.06B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Oct 01
Burrows Scott L
Officer · 229 sh · $21,428
Oct 01
Burrows Scott L
Officer · 1.50K sh · $135,405
Oct 01
Burrows Scott L
Officer · 3.07K sh · $285,449
Oct 01
Burrows Scott L
Officer · 600 sh · $53,442
Oct 01
Burrows Scott L
Officer · 2.10K sh · $193,032
Sep 30
Burrows Scott L
Officer · 17.50K sh · $1.57M
Sep 02
Burrows Scott L
Officer · 18.23K sh · $1.63M
Sep 02
King-Jones Heidy
Officer · 400 sh · $36,000
Sep 01
King-Jones Heidy
Officer · 16.55K sh · $1.44M
Sep 01
Burrows Scott L
Officer · 900 sh · $77,625
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Oct 09
SC 13D/A: Fairmount Funds Management LLC
9.2% of class · View original SEC filing ↗
Oct 01
SC 13G: Paradigm Biocapital Advisors LP
Aug 14
SC 13G/A: RTW INVESTMENTS, LP
Aug 14
SC 13G/A: PERCEPTIVE ADVISORS LLC
Jun 23
SC 13D/A: Fairmount Funds Management LLC
9.2% of class · View original SEC filing ↗
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
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