Security record · archived quarter
SYRE
Spyre Therapeutics, Inc. · Healthcare · Biotechnology
13Tracked holders
-1Δ holders
23.21MShares held
$388.94MReported value
+1New positions
−2Exits
Momentum inputs (comparable managers):
holder breadth -7.1% ·
share flow -1.7% ·
net new positions -7.7%
— formula
Broad distribution — falling shares and fewer holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q3 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 99 | +22 | 55.43M | $4.93B | +25 | −3 |
| Q1 2026 | 80 | +10 | 41.69M | $2.10B | +12 | −2 |
| Q4 2025 | 69 | +2 | 41.90M | $1.37B | +2 | — |
| Q3 2025 | 13 | -1 | 23.21M | $388.94M | +1 | −2 |
| Q2 2025 | 11 | 0 | 22.40M | $335.38M | +2 | −2 |
| Q1 2025 | 8 | -2 | 6.01M | $96.96M | — | −2 |
| Q4 2024 | 10 | +1 | 7.67M | $178.64M | +2 | −1 |
| Q3 2024 | 8 | 0 | 4.78M | $140.58M | +1 | −1 |
| Q2 2024 | 8 | — | 3.96M | $93.00M | — | — |
Who holds it · Q3 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 9.06M | +0.1% | $151.85M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 2 | Fidelity (FMR) ✦ | 9.06M | +0.1% | $151.85M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 3 | Fidelity (FMR) ✦ | 9.06M | +0.1% | $151.85M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 4 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 5 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 6 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 7 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 8 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 9 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 10 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 11 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 12 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 13 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 14 | BlackRock ✦ (passive) | 3.98M | -0.6% | $66.75M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 15 | The Vanguard Group ✦ (passive) | 3.05M | -0.5% | $51.13M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 16 | The Vanguard Group ✦ (passive) | 3.05M | -0.5% | $51.13M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 17 | The Vanguard Group ✦ (passive) | 3.05M | -0.5% | $51.13M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 18 | The Vanguard Group ✦ (passive) | 3.05M | -0.5% | $51.13M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 19 | The Vanguard Group ✦ (passive) | 3.05M | -0.5% | $51.13M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 20 | State Street Global Advisors ✦ (passive) | 1.79M | +11.9% | $29.92M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 21 | Wellington Management ✦ | 1.64M | +8.4% | $27.49M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 22 | Wellington Management ✦ | 1.64M | +8.4% | $27.49M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 23 | Wellington Management ✦ | 1.64M | +8.4% | $27.49M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 24 | Wellington Management ✦ | 1.64M | +8.4% | $27.49M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 25 | Wellington Management ✦ | 1.64M | +8.4% | $27.49M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 26 | Geode Capital Management ✦ (passive) | 1.23M | -0.2% | $20.54M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 27 | Geode Capital Management ✦ (passive) | 1.23M | -0.2% | $20.54M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 28 | T. Rowe Price ✦ | 620.62K | -33.3% | $10.40M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 29 | T. Rowe Price ✦ | 620.62K | -33.3% | $10.40M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 30 | JPMorgan Chase ✦ | 551.97K | — | $9.25M | 0.0% | n/c | 1 | SEC ↗ |
| 31 | JPMorgan Chase ✦ | 551.97K | — | $9.25M | 0.0% | n/c | 1 | SEC ↗ |
| 32 | JPMorgan Chase ✦ | 551.97K | — | $9.25M | 0.0% | n/c | 1 | SEC ↗ |
| 33 | JPMorgan Chase ✦ | 551.97K | — | $9.25M | 0.0% | n/c | 1 | SEC ↗ |
| 34 | JPMorgan Chase ✦ | 551.97K | — | $9.25M | 0.0% | n/c | 1 | SEC ↗ |
| 35 | JPMorgan Chase ✦ | 551.97K | — | $9.25M | 0.0% | n/c | 1 | SEC ↗ |
| 36 | JPMorgan Chase ✦ | 551.97K | — | $9.25M | 0.0% | n/c | 1 | SEC ↗ |
| 37 | JPMorgan Chase ✦ | 551.97K | — | $9.25M | 0.0% | n/c | 1 | SEC ↗ |
| 38 | Millennium Management ✦ | 408.20K | New | $6.84M | 0.0% | New | 1 | SEC ↗ |
| 39 | Morgan Stanley ✦ | 334.72K | — | $5.61M | 0.0% | n/c | 1 | SEC ↗ |
| 40 | Morgan Stanley ✦ | 334.72K | — | $5.61M | 0.0% | n/c | 1 | SEC ↗ |
| 41 | Morgan Stanley ✦ | 334.72K | — | $5.61M | 0.0% | n/c | 1 | SEC ↗ |
| 42 | Morgan Stanley ✦ | 334.72K | — | $5.61M | 0.0% | n/c | 1 | SEC ↗ |
| 43 | Morgan Stanley ✦ | 334.72K | — | $5.61M | 0.0% | n/c | 1 | SEC ↗ |
| 44 | Morgan Stanley ✦ | 334.72K | — | $5.61M | 0.0% | n/c | 1 | SEC ↗ |
| 45 | Goldman Sachs Group ✦ | 329.53K | — | $5.52M | 0.0% | n/c | 1 | SEC ↗ |
| 46 | Goldman Sachs Group ✦ | 329.53K | — | $5.52M | 0.0% | n/c | 1 | SEC ↗ |
| 47 | Capital World Investors ✦ | 200.17K | -42.9% | $3.35M | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 48 | AQR Capital Management ✦ | 17.05K | -5.2% | $285,709 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 49 | AQR Capital Management ✦ | 17.05K | -5.2% | $285,709 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 50 | AQR Capital Management ✦ | 17.05K | -5.2% | $285,709 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 51 | AQR Capital Management ✦ | 17.05K | -5.2% | $285,709 | 0.0% | ▼ Trim | 2 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| Millennium Management | $6.84M | 0.0% |
Exited
| Adage Capital Partners | $9.13M | was 0.0% |
| Renaissance Technologies | $463,112 | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 197 holders, 82.12M shares, $4.06B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Aug 07
Albers Jeffrey W.
Director · 5.00K sh · $522,350
Aug 07
Albers Jeffrey W.
Director · 8.00K sh · $835,040
Aug 07
Albers Jeffrey W.
Director · 10.00K sh · $1.05M
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Aug 14
SC 13G/A — RTW INVESTMENTS, LP
Aug 14
SC 13G/A — PERCEPTIVE ADVISORS LLC
Jun 23
SC 13D/A — Fairmount Funds Management LLC
9.2% of class · View original SEC filing ↗
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q3 2025 ·
Methodology ·
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