SYRE
Spyre Therapeutics, Inc. · Healthcare · Biotechnology
Momentum inputs (comparable managers): holder breadth 0.0% · share flow +1.2% · net new positions 0.0% · formula
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q2 2025
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q3 2026 | 2 | +2 | 602.45K | $53.61M | +2 | n/a |
| Q2 2026 | 99 | +22 | 55.44M | $4.93B | +25 | −3 |
| Q1 2026 | 80 | +10 | 41.69M | $2.10B | +12 | −2 |
| Q4 2025 | 69 | +2 | 41.90M | $1.37B | +2 | n/a |
| Q3 2025 | 13 | -1 | 23.21M | $388.94M | +1 | −2 |
| Q2 2025 | 11 | 0 | 22.40M | $335.38M | +2 | −2 |
| Q1 2025 | 8 | -2 | 6.01M | $96.96M | n/a | −2 |
| Q4 2024 | 10 | +1 | 7.67M | $178.64M | +2 | −1 |
| Q3 2024 | 8 | 0 | 4.78M | $140.58M | +1 | −1 |
| Q2 2024 | 8 | n/a | 3.96M | $93.00M | n/a | n/a |
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 9.05M | n/a | $135.52M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 2 | BlackRock ✦ (passive) | 4.01M | n/a | $59.99M | 0.0% | n/c | 1 | SEC ↗ ×14 |
| 3 | The Vanguard Group ✦ (passive) | 3.07M | n/a | $45.91M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 4 | State Street Global Advisors ✦ (passive) | 1.60M | -6.0% | $23.88M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 5 | Wellington Management ✦ | 1.51M | -5.0% | $22.66M | 0.0% | ▼ Trim | 5 | SEC ↗ ×5 |
| 6 | Geode Capital Management ✦ (passive) | 1.23M | +15.8% | $18.37M | 0.0% | ▲ Add | 5 | SEC ↗ ×2 |
| 7 | T. Rowe Price ✦ | 930.48K | +274.4% | $13.93M | 0.0% | ▲ Add | 5 | SEC ↗ ×2 |
| 8 | Adage Capital Partners ✦ | 610.20K | -24.0% | $9.13M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 9 | Capital World Investors ✦ | 350.77K | 0.0% | $5.25M | 0.0% | Held | 3 | SEC ↗ |
| 10 | Renaissance Technologies ✦ | 30.94K | New | $463,112 | 0.0% | New | 1 | SEC ↗ |
| 11 | AQR Capital Management ✦ | 17.97K | New | $269,057 | 0.0% | New | 1 | SEC ↗ ×5 |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| Renaissance Technologies | $463,112 | 0.0% |
| AQR Capital Management | $269,057 | 0.0% |
Exited
| Citadel Advisors | $2.11M | was 0.0% |
| Soros Fund Management | $2.02M | was 0.1% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 197 holders, 82.12M shares, $4.06B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Officer · 229 sh · $21,428
Officer · 1.50K sh · $135,405
Officer · 3.07K sh · $285,449
Officer · 600 sh · $53,442
Officer · 2.10K sh · $193,032
Officer · 17.50K sh · $1.57M
Officer · 18.23K sh · $1.63M
Officer · 400 sh · $36,000
Officer · 16.55K sh · $1.44M
Officer · 900 sh · $77,625
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
9.2% of class · View original SEC filing ↗
9.2% of class · View original SEC filing ↗