Security record · archived quarter
AMLX
Amylyx Pharmaceuticals, Inc. · Healthcare · Biotechnology
73Tracked holders
0Δ holders
62.47MShares held
$754.72MReported value
+0New positions
−0Exits
Momentum inputs (comparable managers): holder breadth 0.0% · share flow +5.1% · net new positions 0.0% — formula
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 78 | +11 | 60.67M | $1.09B | +14 | −3 |
| Q1 2026 | 70 | -3 | 62.54M | $868.96M | +6 | −9 |
| Q4 2025 | 73 | 0 | 62.47M | $754.72M | — | — |
| Q3 2025 | 18 | +1 | 42.12M | $572.37M | +1 | — |
| Q2 2025 | 14 | -1 | 33.34M | $213.68M | — | −1 |
| Q1 2025 | 12 | +1 | 15.66M | $55.46M | +2 | −1 |
| Q4 2024 | 11 | 0 | 5.41M | $20.47M | +1 | −1 |
| Q3 2024 | 10 | +2 | 5.23M | $16.93M | +2 | — |
| Q2 2024 | 8 | — | 10.16M | $19.31M | — | — |
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 16.52M | +45.2% | $199.54M | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 2 | BlackRock ✦ (passive) | 9.05M | +26.8% | $109.38M | 0.0% | ▲ Add | 3 | SEC ↗ ×12 |
| 3 | The Vanguard Group ✦ (passive) | 5.80M | +10.1% | $70.12M | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 4 | Janus Henderson Group Plc | 4.47M | — | $53.99M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 5 | Adage Capital Partners ✦ | 2.78M | -59.3% | $33.55M | 0.1% | ▼ Trim | 4 | SEC ↗ |
| 6 | Goldman Sachs Group ✦ | 2.61M | +30.0% | $31.57M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 7 | Morgan Stanley ✦ | 2.36M | +21.0% | $28.51M | 0.0% | ▲ Add | 2 | SEC ↗ ×8 |
| 8 | Geode Capital Management ✦ (passive) | 2.17M | +19.5% | $26.16M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 9 | State Street Global Advisors ✦ (passive) | 2.07M | +27.7% | $25.00M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 10 | Bank Of America Corp /De/ | 1.34M | — | $16.14M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 11 | Deutsche Bank Ag\ | 1.33M | — | $16.11M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 12 | Franklin Resources Inc | 1.20M | — | $14.50M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 13 | Connor, Clark & Lunn Investment… | 1.00M | — | $12.13M | 0.0% | n/c | 1 | SEC ↗ |
| 14 | Northern Trust Corp | 937.76K | — | $11.33M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 15 | Balyasny Asset Management L.P. | 858.68K | — | $10.37M | 0.0% | n/c | 1 | SEC ↗ |
| 16 | Dimensional Fund Advisors Lp | 771.25K | — | $9.32M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 17 | Charles Schwab Investment… | 712.99K | — | $8.61M | 0.0% | n/c | 1 | SEC ↗ |
| 18 | UBS Group AG | 543.32K | — | $6.56M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 19 | Ameriprise Financial Inc | 502.37K | — | $6.07M | 0.0% | n/c | 1 | SEC ↗ |
| 20 | Federated Hermes, Inc. | 457.41K | — | $5.53M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 21 | Qube Research & Technologies Ltd | 412.87K | — | $4.99M | 0.0% | n/c | 1 | SEC ↗ |
| 22 | Citadel Advisors ✦ | 344.97K | +47.0% | $4.17M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 23 | Two Sigma Investments ✦ | 344.40K | +249.9% | $4.16M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 24 | Point72 Asset Management ✦ | 335.00K | -88.0% | $4.05M | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 25 | Barclays Plc | 295.18K | — | $3.57M | 0.0% | n/c | 1 | SEC ↗ |
| 26 | Nuveen, LLC | 283.95K | — | $3.43M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 27 | Jane Street Group, Llc | 263.24K | — | $3.18M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 28 | Wellington Management ✦ | 225.78K | -4.4% | $2.73M | 0.0% | ▼ Trim | 5 | SEC ↗ ×3 |
| 29 | Bank of New York Mellon Corp | 217.35K | — | $2.63M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 30 | Renaissance Technologies ✦ | 192.50K | +867.3% | $2.33M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 31 | Invesco Ltd. | 175.91K | — | $2.13M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 32 | Swiss National Bank | 161.70K | — | $1.95M | 0.0% | n/c | 1 | SEC ↗ |
| 33 | Wells Fargo & Company/Mn | 146.31K | — | $1.77M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 34 | Bank Of Montreal /Can/ | 138.53K | — | $1.67M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 35 | T. Rowe Price ✦ | 107.55K | +7.1% | $1.30M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 36 | Rhumbline Advisers | 99.27K | — | $1.20M | 0.0% | n/c | 1 | SEC ↗ |
| 37 | UBS AM, a distinct business unit of… | 98.84K | — | $1.19M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 38 | State Of Wisconsin Investment Board | 84.14K | — | $1.02M | 0.0% | n/c | 1 | SEC ↗ |
| 39 | California State Teachers… | 79.09K | — | $955,407 | 0.0% | n/c | 1 | SEC ↗ |
| 40 | Squarepoint Ops LLC | 76.56K | — | $924,869 | 0.0% | n/c | 1 | SEC ↗ |
| 41 | D. E. Shaw & Co. ✦ | 73.22K | +6.3% | $884,546 | 0.0% | ▲ Add | 7 | SEC ↗ |
| 42 | Legal & General Group Plc | 72.61K | — | $877,153 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 43 | Alliancebernstein L.P. | 71.50K | — | $863,720 | 0.0% | n/c | 1 | SEC ↗ |
| 44 | Susquehanna International Group, Llp | 68.89K | — | $832,215 | 0.0% | n/c | 1 | SEC ↗ |
| 45 | JPMorgan Chase ✦ | 66.55K | -7.2% | $803,888 | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 46 | Russell Investments Group, Ltd. | 65.44K | — | $790,491 | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 47 | Sei Investments Co | 52.86K | — | $638,500 | 0.0% | n/c | 1 | SEC ↗ |
| 48 | Millennium Management ✦ | 46.45K | -88.9% | $561,176 | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 49 | Mariner, LLC | 46.34K | — | $559,858 | 0.0% | n/c | 1 | SEC ↗ |
| 50 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 41.17K | — | $497,285 | 0.0% | n/c | 1 | SEC ↗ |
| 51 | Citigroup Inc | 38.03K | — | $459,427 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 52 | Zurcher Kantonalbank (Zurich… | 35.88K | — | $433,394 | 0.0% | n/c | 1 | SEC ↗ |
| 53 | AQR Capital Management ✦ | 27.85K | -62.2% | $336,391 | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 54 | Manufacturers Life Insurance… | 26.99K | — | $326,015 | 0.0% | n/c | 1 | SEC ↗ |
| 55 | Bnp Paribas Financial Markets | 25.20K | — | $304,428 | 0.0% | n/c | 1 | SEC ↗ |
| 56 | Tudor Investment Corp Et Al | 22.40K | — | $270,616 | 0.0% | n/c | 1 | SEC ↗ |
| 57 | New York State Common Retirement… | 21.90K | — | $264,552 | 0.0% | n/c | 1 | SEC ↗ |
| 58 | ProShare Advisors LLC | 21.07K | — | $254,501 | 0.0% | n/c | 1 | SEC ↗ |
| 59 | Brown Advisory Inc | 19.93K | — | $240,754 | 0.0% | n/c | 1 | SEC ↗ |
| 60 | Royal Bank Of Canada | 15.64K | — | $188,000 | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 61 | Voya Investment Management Llc | 15.25K | — | $184,184 | 0.0% | n/c | 1 | SEC ↗ |
| 62 | Victory Capital Management Inc | 10.55K | — | $127,468 | 0.0% | n/c | 1 | SEC ↗ |
| 63 | Mirae Asset Global Investments Co.… | 5.34K | — | $64,471 | 0.0% | n/c | 1 | SEC ↗ |
| 64 | Simplex Trading, Llc | 3.73K | — | $45,022 | 0.0% | n/c | 1 | SEC ↗ |
| 65 | Walleye Trading LLC | 2.83K | — | $34,126 | 0.0% | n/c | 1 | SEC ↗ |
| 66 | Us Bancorp \De\ | 2.00K | — | $24,160 | 0.0% | n/c | 1 | SEC ↗ |
| 67 | BNP Paribas Asset Management… | 1.31K | — | $16,000 | 0.0% | n/c | 1 | SEC ↗ |
| 68 | Cwm, Llc | 1.19K | — | $14,000 | 0.0% | n/c | 1 | SEC ↗ |
| 69 | Pnc Financial Services Group, Inc. | 438 | — | $5,291 | 0.0% | n/c | 1 | SEC ↗ |
| 70 | Rockefeller Capital Management L.P. | 261 | — | $3,152 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 71 | Osaic Holdings, Inc. | 249 | — | $3,007 | 0.0% | n/c | 1 | SEC ↗ |
| 72 | Daiwa Securities Group Inc. | 266 | — | $3,000 | 0.0% | n/c | 1 | SEC ↗ |
| 73 | Jones Financial Companies Lllp | 30 | — | $362 | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| No new tracked buyers this quarter. |
Exited
| No tracked exits this quarter. |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 170 holders, 113.99M shares, $1.58B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Oct 05
MILNE GEORGE M JR
Director · 30.00K sh · $830,904
Sep 10
Cohen Joshua B
Officer, Director · 29.55K sh · $950,040
Sep 10
Cohen Joshua B
Officer, Director · 919 sh · $30,464
Sep 10
Mazzariello Gina
Officer · 9.53K sh · $309,140
Sep 10
Mazzariello Gina
Officer · 11 sh · $367
Sep 10
FRATES JAMES M
Officer · 9.77K sh · $315,195
Sep 10
FRATES JAMES M
Officer · 1.04K sh · $34,626
Sep 10
Bedrosian Camille L
Officer · 7.95K sh · $256,004
Sep 10
Bedrosian Camille L
Officer · 2.08K sh · $68,864
Sep 10
Klee Justin B.
Officer, Director · 29.02K sh · $932,553
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
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