Security record · archived quarter
IONS
Ionis Pharmaceuticals, Inc. · Healthcare · Biotechnology
139Tracked holders
-2Δ holders
142.62MShares held
$9.86BReported value
+6New positions
−9Exits
Momentum inputs (comparable managers):
holder breadth -1.4% ·
share flow +6.9% ·
net new positions -2.2%
· formula
Concentrated accumulation: rising shares among fewer holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q1 2026
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q3 2026 | 2 | -1 | 48.54K | $2.16M | n/a | −2 |
| Q2 2026 | 137 | +2 | 148.57M | $11.08B | +6 | −5 |
| Q1 2026 | 139 | -2 | 142.62M | $9.86B | +6 | −9 |
| Q4 2025 | 142 | 0 | 143.10M | $10.36B | +1 | n/a |
| Q3 2025 | 25 | +4 | 95.56M | $6.25B | +5 | −2 |
| Q2 2025 | 19 | +1 | 95.25M | $3.76B | +1 | n/a |
| Q1 2025 | 15 | -1 | 43.90M | $1.32B | +1 | −2 |
| Q4 2024 | 16 | -1 | 43.25M | $1.51B | n/a | −1 |
| Q3 2024 | 16 | -1 | 34.86M | $1.40B | n/a | −1 |
| Q2 2024 | 17 | n/a | 24.68M | $1.18B | n/a | n/a |
Who holds it · Q1 2026
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 24.56M | +2.0% | $1.84B | 0.1% | ▲ Add | 4 | SEC ↗ ×6 |
| 2 | Capital World Investors ✦ | 21.19M | +18.0% | $1.59B | 0.2% | ▲ Add | 8 | SEC ↗ |
| 3 | BlackRock ✦ (passive) | 10.44M | -1.9% | $784.13M | 0.0% | ▼ Trim | 4 | SEC ↗ ×23 |
| 4 | Vanguard Capital Management Llc | 7.12M | n/a | $534.52M | 0.0% | n/c | 1 | SEC ↗ |
| 5 | Wellington Management ✦ | 6.39M | +2.1% | $479.96M | 0.1% | ▲ Add | 8 | SEC ↗ ×13 |
| 6 | Two Sigma Investments ✦ | 5.86M | +120.3% | $439.85M | 0.4% | ▲ Add | 8 | SEC ↗ |
| 7 | Geode Capital Management ✦ (passive) | 3.98M | +26.5% | $305.20M | 0.0% | ▲ Add | 8 | SEC ↗ ×2 |
| 8 | State Street Global Advisors ✦ (passive) | 4.00M | +0.5% | $300.03M | 0.0% | ▲ Add | 6 | SEC ↗ ×2 |
| 9 | Royal Bank Of Canada | 3.80M | +239.8% | $285.48M | 0.1% | ▲ Add | 2 | SEC ↗ ×15 |
| 10 | T. Rowe Price ✦ | 3.03M | +1.2% | $227.17M | 0.0% | ▲ Add | 8 | SEC ↗ ×2 |
| 11 | JPMorgan Chase ✦ | 2.36M | +2.5% | $171.41M | 0.0% | ▲ Add | 3 | SEC ↗ ×11 |
| 12 | Tweedy, Browne ✦ | 2.28M | -7.7% | $170.88M | 13.6% | ▼ Trim | 8 | SEC ↗ |
| 13 | Artisan Partners Limited Partnership | 2.06M | +74.2% | $154.56M | 0.3% | ▲ Add | 2 | SEC ↗ |
| 14 | Goldman Sachs Group ✦ | 1.70M | +98.6% | $127.64M | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 15 | American Century Companies Inc | 1.66M | +2.9% | $124.94M | 0.1% | ▲ Add | 2 | SEC ↗ |
| 16 | Charles Schwab Investment… | 1.58M | +2.7% | $118.89M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 17 | Franklin Resources Inc | 1.58M | +19.2% | $118.27M | 0.0% | ▲ Add | 2 | SEC ↗ ×4 |
| 18 | UBS AM, a distinct business unit of… | 1.48M | +6.3% | $110.81M | 0.0% | ▲ Add | 2 | SEC ↗ ×11 |
| 19 | Pictet Asset Management Holding SA | 1.43M | +1.2% | $107.08M | 0.1% | ▲ Add | 2 | SEC ↗ |
| 20 | Invesco Ltd. | 1.28M | +0.6% | $95.92M | 0.0% | ▲ Add | 2 | SEC ↗ ×6 |
| 21 | Millennium Management ✦ | 1.05M | +1027.5% | $78.96M | 0.1% | ▲ Add | 8 | SEC ↗ |
| 22 | Morgan Stanley ✦ | 1.03M | +0.7% | $77.08M | 0.0% | ▲ Add | 3 | SEC ↗ ×12 |
| 23 | BNP Paribas Asset Management… | 4.04M | -18.9% | $72.90M | 0.1% | ▼ Trim | 2 | SEC ↗ ×4 |
| 24 | Citadel Advisors ✦ | 942.53K | -55.9% | $70.77M | 0.1% | ▼ Trim | 8 | SEC ↗ ×3 |
| 25 | Connor, Clark & Lunn Investment… | 874.09K | -18.8% | $65.64M | 0.2% | ▼ Trim | 2 | SEC ↗ |
| 26 | Northern Trust Corp | 868.18K | +2.5% | $65.19M | 0.0% | ▲ Add | 2 | SEC ↗ ×4 |
| 27 | Bank Of America Corp /De/ | 840.60K | +7.3% | $63.12M | 0.0% | ▲ Add | 2 | SEC ↗ ×7 |
| 28 | UBS Group AG | 808.44K | -22.6% | $60.71M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 29 | Nomura Asset Management… | 785.28K | -9.2% | $58.97M | 0.1% | ▼ Trim | 2 | SEC ↗ |
| 30 | Arrowstreet Capital ✦ | 737.86K | -30.6% | $55.41M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 31 | Squarepoint Ops LLC | 695.28K | +59.4% | $52.21M | 0.1% | ▲ Add | 2 | SEC ↗ |
| 32 | Massachusetts Financial Services Co… | 666.12K | -18.0% | $50.02M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 33 | Ameriprise Financial Inc | 660.14K | +10.2% | $49.57M | 0.0% | ▲ Add | 2 | SEC ↗ ×5 |
| 34 | Nuveen, LLC | 648.50K | -1.9% | $48.70M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 35 | Td Asset Management Inc | 529.95K | -31.5% | $39.79M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 36 | Bank of New York Mellon Corp | 514.62K | -31.7% | $38.64M | 0.0% | ▼ Trim | 2 | SEC ↗ ×13 |
| 37 | Bnp Paribas Financial Markets | 479.46K | +43.3% | $36.00M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 38 | Alyeska Investment Group, L.P. | 473.15K | -1.8% | $35.53M | 0.1% | ▼ Trim | 2 | SEC ↗ |
| 39 | First Trust Advisors Lp | 468.36K | -10.8% | $35.17M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 40 | Neuberger Berman Group LLC | 443.27K | +310.3% | $33.29M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 41 | D. E. Shaw & Co. ✦ | 429.60K | +29.1% | $32.26M | 0.0% | ▲ Add | 3 | SEC ↗ ×2 |
| 42 | Alliancebernstein L.P. | 400.67K | +17.2% | $31.70M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 43 | New York State Common Retirement… | 350.41K | +44.9% | $26.31M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 44 | Capital Research Global Investors | 323.01K | New | $24.26M | 0.0% | New | 1 | SEC ↗ |
| 45 | Renaissance Technologies ✦ | 305.55K | +36.6% | $22.94M | 0.0% | ▲ Add | 8 | SEC ↗ |
| 46 | Swiss National Bank | 304.50K | +2.0% | $22.86M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 47 | Legal & General Group Plc | 294.68K | -9.4% | $22.13M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 48 | Barclays Plc | 289.87K | -65.6% | $21.77M | 0.0% | ▼ Trim | 2 | SEC ↗ ×6 |
| 49 | ARK Investment Management ✦ | 288.72K | -31.7% | $21.68M | 0.2% | ▼ Trim | 8 | SEC ↗ |
| 50 | Focus Partners Wealth | 5.44M | -3.2% | $20.45M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 51 | Dimensional Fund Advisors Lp | 267.21K | +51.8% | $20.06M | 0.0% | ▲ Add | 2 | SEC ↗ ×5 |
| 52 | California Public Employees… | 255.49K | +19.7% | $19.18M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 53 | Hrt Financial Lp | 252.25K | +1000.2% | $18.94M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 54 | Raymond James Financial Inc | 235.12K | -8.6% | $17.66M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 55 | Universal- Beteiligungs- und… | 219.65K | 0.0% | $16.49M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 56 | Nomura Holdings Inc | 199.14K | -77.1% | $14.95M | 0.1% | ▼ Trim | 2 | SEC ↗ ×2 |
| 57 | Stifel Financial Corp | 196.70K | -1.1% | $14.77M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 58 | Corient Private Wealth LP | 196.60K | -54.4% | $14.76M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 59 | Jane Street Group, Llc | 191.82K | +529.5% | $14.40M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 60 | Wells Fargo & Company/Mn | 189.85K | -32.2% | $14.26M | 0.0% | ▼ Trim | 2 | SEC ↗ ×6 |
| 61 | Hsbc Holdings Plc | 185.97K | +245.1% | $13.97M | 0.0% | ▲ Add | 2 | SEC ↗ ×5 |
| 62 | California State Teachers… | 176.49K | +22.4% | $13.25M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 63 | Rhumbline Advisers | 173.44K | -1.1% | $13.02M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 64 | DZ BANK AG Deutsche Zentral… | 167.66K | 0.0% | $12.59M | 0.0% | Held | 2 | SEC ↗ |
| 65 | Deutsche Bank Ag\ | 159.89K | +7.0% | $12.01M | 0.0% | ▲ Add | 2 | SEC ↗ ×5 |
| 66 | Sei Investments Co | 262.22K | +18.7% | $11.96M | 0.0% | ▲ Add | 2 | SEC ↗ ×4 |
| 67 | State Of Wisconsin Investment Board | 3.10M | +0.1% | $11.76M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 68 | Manufacturers Life Insurance… | 149.54K | -2.4% | $11.23M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 69 | Citigroup Inc | 146.54K | +64.0% | $11.00M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 70 | Fisher Asset Management ✦ | 141.54K | -0.1% | $10.63M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 71 | State Board Of Administration Of… | 135.88K | 0.0% | $10.20M | 0.0% | Held | 2 | SEC ↗ |
| 72 | Aberdeen Group plc | 113.84K | +293.6% | $8.55M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 73 | Victory Capital Management Inc | 108.74K | +34.7% | $8.17M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 74 | Gotham Asset Management ✦ | 98.97K | +129.0% | $7.43M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 75 | Marshall Wace ✦ | 95.95K | -62.6% | $7.21M | 0.0% | ▼ Trim | 8 | SEC ↗ ×2 |
| 76 | Envestnet Asset Management Inc | 93.38K | +3.9% | $7.01M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 77 | Sumitomo Mitsui Trust Group, Inc. | 81.88K | -12.7% | $6.15M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 78 | Voya Investment Management Llc | 69.14K | -6.3% | $5.19M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 79 | Janus Henderson Group Plc | 68.19K | 0.0% | $5.12M | 0.0% | Held | 2 | SEC ↗ |
| 80 | Russell Investments Group, Ltd. | 62.92K | +43.3% | $4.72M | 0.0% | ▲ Add | 2 | SEC ↗ ×7 |
| 81 | Zurcher Kantonalbank (Zurich… | 60.24K | +23.1% | $4.52M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 82 | Quantinno Capital Management LP | 55.50K | +17.1% | $4.17M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 83 | Creative Planning | 52.23K | -4.7% | $3.92M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 84 | Adage Capital Partners ✦ | 50.00K | -64.3% | $3.75M | 0.0% | ▼ Trim | 8 | SEC ↗ |
| 85 | Tudor Investment Corp Et Al | 48.24K | +1217.8% | $3.62M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 86 | Ensign Peak Advisors, Inc | 46.00K | -14.3% | $3.45M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 87 | Bamco Inc /Ny/ | 45.00K | +25.0% | $3.38M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 88 | Qube Research & Technologies Ltd | 42.86K | New | $3.22M | 0.0% | New | 1 | SEC ↗ |
| 89 | Prudential Financial Inc | 35.27K | +46.9% | $2.65M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 90 | Peak6 Llc | 34.42K | -43.8% | $2.58M | 0.1% | ▼ Trim | 2 | SEC ↗ |
| 91 | Blair William & Co/Il | 33.86K | +0.2% | $2.54M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 92 | Assenagon Asset Management S.A. | 33.67K | +14.9% | $2.53M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 93 | Tidal Investments LLC | 34.43K | +92.3% | $2.51M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 94 | Swedbank AB | 32.25K | +18.4% | $2.42M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 95 | LPL Financial LLC | 31.93K | +2.8% | $2.40M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 96 | AQR Capital Management ✦ | 28.78K | +53.4% | $2.16M | 0.0% | ▲ Add | 3 | SEC ↗ ×4 |
| 97 | Loomis Sayles & Co L P | 28.62K | New | $2.15M | 0.0% | New | 1 | SEC ↗ ×2 |
| 98 | Bank Of Montreal /Can/ | 26.59K | -26.9% | $2.00M | 0.0% | ▼ Trim | 2 | SEC ↗ ×6 |
| 99 | Jones Financial Companies Lllp | 26.72K | +312.2% | $1.93M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 100 | Lazard Asset Management Llc | 25.41K | -45.2% | $1.91M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| Capital Research Global… | $24.26M | 0.0% |
| Qube Research & Technologies… | $3.22M | 0.0% |
| Loomis Sayles & Co L P | $2.15M | 0.0% |
Exited
| Norges Bank | $25.33M | was 0.0% |
| Balyasny Asset Management L.P. | $9.54M | was 0.0% |
| Healthcare Of Ontario Pension… | $8.70M | was 0.0% |
| Simplex Trading, Llc | $7.65M | was 0.2% |
| Bridgewater Associates | $5.36M | was 0.0% |
| Mariner, LLC | $3.78M | was 0.0% |
| Bank Of Nova Scotia | $331,392 | was 0.0% |
| Clearbridge Investments, LLC | $214,784 | was 0.0% |
| Daiwa Securities Group Inc. | $38,000 | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 490 holders, 170.17M shares, $11.94B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Oct 16
Devers Shannon L.
Officer · 1.36K sh · $59,082
Oct 16
Swayze Eric
Officer · 53 sh · $2,308
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q1 2026 ·
Methodology ·
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