Security record · archived quarter
IONS
Ionis Pharmaceuticals, Inc. · Healthcare · Biotechnology
142Tracked holders
0Δ holders
143.10MShares held
$10.36BReported value
+1New positions
−0Exits
Momentum inputs (comparable managers): holder breadth 0.0% · share flow +3.0% · net new positions +0.7% — formula
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 139 | +2 | 148.59M | $11.08B | +6 | −3 |
| Q1 2026 | 139 | -2 | 142.62M | $9.86B | +6 | −9 |
| Q4 2025 | 142 | 0 | 143.10M | $10.36B | +1 | — |
| Q3 2025 | 25 | +4 | 95.56M | $6.25B | +5 | −2 |
| Q2 2025 | 19 | +1 | 95.25M | $3.76B | +1 | — |
| Q1 2025 | 15 | -1 | 43.90M | $1.32B | +1 | −2 |
| Q4 2024 | 16 | -1 | 43.25M | $1.51B | — | −1 |
| Q3 2024 | 16 | -1 | 34.86M | $1.40B | — | −1 |
| Q2 2024 | 17 | — | 24.68M | $1.18B | — | — |
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 24.07M | +1.6% | $1.90B | 0.1% | ▲ Add | 3 | SEC ↗ |
| 2 | Fidelity (FMR) ✦ | 24.07M | +1.6% | $1.90B | 0.1% | ▲ Add | 3 | SEC ↗ |
| 3 | Fidelity (FMR) ✦ | 24.07M | +1.6% | $1.90B | 0.1% | ▲ Add | 3 | SEC ↗ |
| 4 | Fidelity (FMR) ✦ | 24.07M | +1.6% | $1.90B | 0.1% | ▲ Add | 3 | SEC ↗ |
| 5 | Fidelity (FMR) ✦ | 24.07M | +1.6% | $1.90B | 0.1% | ▲ Add | 3 | SEC ↗ |
| 6 | Fidelity (FMR) ✦ | 24.07M | +1.6% | $1.90B | 0.1% | ▲ Add | 3 | SEC ↗ |
| 7 | Capital World Investors ✦ | 17.96M | +41.2% | $1.42B | 0.2% | ▲ Add | 7 | SEC ↗ |
| 8 | The Vanguard Group ✦ (passive) | 16.44M | -0.2% | $1.30B | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 9 | The Vanguard Group ✦ (passive) | 16.44M | -0.2% | $1.30B | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 10 | The Vanguard Group ✦ (passive) | 16.44M | -0.2% | $1.30B | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 11 | The Vanguard Group ✦ (passive) | 16.44M | -0.2% | $1.30B | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 12 | The Vanguard Group ✦ (passive) | 16.44M | -0.2% | $1.30B | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 13 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 14 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 15 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 16 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 17 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 18 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 19 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 20 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 21 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 22 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 23 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 24 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 25 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 26 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 27 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 28 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 29 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 30 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 31 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 32 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 33 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 34 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 35 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 36 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 37 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 38 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 39 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 40 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 41 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 42 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 43 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 44 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 45 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 46 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 47 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 48 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 49 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 50 | State Street Global Advisors ✦ (passive) | 3.97M | -9.4% | $314.45M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 51 | State Street Global Advisors ✦ (passive) | 3.97M | -9.4% | $314.45M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 52 | State Street Global Advisors ✦ (passive) | 3.97M | -9.4% | $314.45M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 53 | Geode Capital Management ✦ (passive) | 3.15M | +2.7% | $249.16M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 54 | Geode Capital Management ✦ (passive) | 3.15M | +2.7% | $249.16M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 55 | T. Rowe Price ✦ | 2.99M | +9.5% | $236.37M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 56 | T. Rowe Price ✦ | 2.99M | +9.5% | $236.37M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 57 | Two Sigma Investments ✦ | 2.66M | +68.7% | $210.33M | 0.3% | ▲ Add | 7 | SEC ↗ |
| 58 | Two Sigma Investments ✦ | 2.66M | +68.7% | $210.33M | 0.3% | ▲ Add | 7 | SEC ↗ |
| 59 | Two Sigma Investments ✦ | 2.66M | +68.7% | $210.33M | 0.3% | ▲ Add | 7 | SEC ↗ |
| 60 | Tweedy, Browne ✦ | 2.46M | -15.0% | $195.00M | 15.7% | ▼ Trim | 7 | SEC ↗ |
| 61 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 62 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 63 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 64 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 65 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 66 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 67 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 68 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 69 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 70 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 71 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 72 | Citadel Advisors ✦ | 2.13M | -11.1% | $168.87M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 73 | Citadel Advisors ✦ | 2.13M | -11.1% | $168.87M | 0.1% | ▼ Trim | 7 | SEC ↗ |
| 74 | American Century Companies Inc | 1.62M | — | $127.93M | 0.1% | n/c | 1 | SEC ↗ |
| 75 | Charles Schwab Investment… | 1.54M | — | $121.98M | 0.0% | n/c | 1 | SEC ↗ |
| 76 | BNP Paribas Asset Management… | 4.99M | — | $112.67M | 0.1% | n/c | 1 | SEC ↗ |
| 77 | BNP Paribas Asset Management… | 4.99M | — | $112.67M | 0.1% | n/c | 1 | SEC ↗ |
| 78 | BNP Paribas Asset Management… | 4.99M | — | $112.67M | 0.1% | n/c | 1 | SEC ↗ |
| 79 | BNP Paribas Asset Management… | 4.99M | — | $112.67M | 0.1% | n/c | 1 | SEC ↗ |
| 80 | BNP Paribas Asset Management… | 4.99M | — | $112.67M | 0.1% | n/c | 1 | SEC ↗ |
| 81 | Pictet Asset Management Holding SA | 1.42M | — | $112.48M | 0.1% | n/c | 1 | SEC ↗ |
| 82 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 83 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 84 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 85 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 86 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 87 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 88 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 89 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 90 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 91 | UBS AM, a distinct business unit of… | 1.39M | — | $109.85M | 0.0% | n/c | 1 | SEC ↗ |
| 92 | Franklin Resources Inc | 1.32M | — | $104.53M | 0.0% | n/c | 1 | SEC ↗ |
| 93 | Franklin Resources Inc | 1.32M | — | $104.53M | 0.0% | n/c | 1 | SEC ↗ |
| 94 | Franklin Resources Inc | 1.32M | — | $104.53M | 0.0% | n/c | 1 | SEC ↗ |
| 95 | Invesco Ltd. | 1.27M | — | $100.41M | 0.0% | n/c | 1 | SEC ↗ |
| 96 | Invesco Ltd. | 1.27M | — | $100.41M | 0.0% | n/c | 1 | SEC ↗ |
| 97 | Invesco Ltd. | 1.27M | — | $100.41M | 0.0% | n/c | 1 | SEC ↗ |
| 98 | Invesco Ltd. | 1.27M | — | $100.41M | 0.0% | n/c | 1 | SEC ↗ |
| 99 | Invesco Ltd. | 1.27M | — | $100.41M | 0.0% | n/c | 1 | SEC ↗ |
| 100 | Invesco Ltd. | 1.27M | — | $100.41M | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| No new tracked buyers this quarter. |
Exited
| No tracked exits this quarter. |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 490 holders, 170.17M shares, $11.94B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
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