Security record · archived quarter
IONS
Ionis Pharmaceuticals, Inc. · Healthcare · Biotechnology
142Tracked holders
0Δ holders
143.10MShares held
$10.36BReported value
+1New positions
−0Exits
Momentum inputs (comparable managers): holder breadth 0.0% · share flow +3.0% · net new positions +0.7% · formula
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q3 2026 | 2 | -1 | 48.54K | $2.16M | n/a | −1 |
| Q2 2026 | 137 | +2 | 148.57M | $11.08B | +6 | −5 |
| Q1 2026 | 139 | -2 | 142.62M | $9.86B | +6 | −9 |
| Q4 2025 | 142 | 0 | 143.10M | $10.36B | +1 | n/a |
| Q3 2025 | 25 | +4 | 95.56M | $6.25B | +5 | −2 |
| Q2 2025 | 19 | +1 | 95.25M | $3.76B | +1 | n/a |
| Q1 2025 | 15 | -1 | 43.90M | $1.32B | +1 | −2 |
| Q4 2024 | 16 | -1 | 43.25M | $1.51B | n/a | −1 |
| Q3 2024 | 16 | -1 | 34.86M | $1.40B | n/a | −1 |
| Q2 2024 | 17 | n/a | 24.68M | $1.18B | n/a | n/a |
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 24.07M | +1.6% | $1.90B | 0.1% | ▲ Add | 3 | SEC ↗ ×6 |
| 2 | Capital World Investors ✦ | 17.96M | +41.2% | $1.42B | 0.2% | ▲ Add | 7 | SEC ↗ |
| 3 | The Vanguard Group ✦ (passive) | 16.44M | -0.2% | $1.30B | 0.0% | ▼ Trim | 3 | SEC ↗ ×5 |
| 4 | BlackRock ✦ (passive) | 10.65M | +1.9% | $842.35M | 0.0% | ▲ Add | 3 | SEC ↗ ×24 |
| 5 | Wellington Management ✦ | 6.26M | -5.0% | $495.25M | 0.1% | ▼ Trim | 7 | SEC ↗ ×13 |
| 6 | State Street Global Advisors ✦ (passive) | 3.97M | -9.4% | $314.45M | 0.0% | ▼ Trim | 5 | SEC ↗ ×3 |
| 7 | Geode Capital Management ✦ (passive) | 3.15M | +2.7% | $249.16M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 8 | T. Rowe Price ✦ | 2.99M | +9.5% | $236.37M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 9 | Two Sigma Investments ✦ | 2.66M | +68.7% | $210.33M | 0.3% | ▲ Add | 7 | SEC ↗ ×3 |
| 10 | Tweedy, Browne ✦ | 2.46M | -15.0% | $195.00M | 15.7% | ▼ Trim | 7 | SEC ↗ |
| 11 | JPMorgan Chase ✦ | 2.30M | +111.7% | $182.33M | 0.0% | ▲ Add | 2 | SEC ↗ ×11 |
| 12 | Citadel Advisors ✦ | 2.13M | -11.1% | $168.87M | 0.1% | ▼ Trim | 7 | SEC ↗ ×2 |
| 13 | American Century Companies Inc | 1.62M | n/a | $127.93M | 0.1% | n/c | 1 | SEC ↗ |
| 14 | Charles Schwab Investment… | 1.54M | n/a | $121.98M | 0.0% | n/c | 1 | SEC ↗ |
| 15 | BNP Paribas Asset Management… | 4.99M | n/a | $112.67M | 0.1% | n/c | 1 | SEC ↗ ×5 |
| 16 | Pictet Asset Management Holding SA | 1.42M | n/a | $112.48M | 0.1% | n/c | 1 | SEC ↗ |
| 17 | UBS AM, a distinct business unit of… | 1.39M | n/a | $109.85M | 0.0% | n/c | 1 | SEC ↗ ×10 |
| 18 | Franklin Resources Inc | 1.32M | n/a | $104.53M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 19 | Invesco Ltd. | 1.27M | n/a | $100.41M | 0.0% | n/c | 1 | SEC ↗ ×7 |
| 20 | Artisan Partners Limited Partnership | 1.18M | n/a | $93.46M | 0.1% | n/c | 1 | SEC ↗ |
| 21 | Royal Bank Of Canada | 1.12M | n/a | $88.51M | 0.0% | n/c | 1 | SEC ↗ ×11 |
| 22 | Connor, Clark & Lunn Investment… | 1.08M | n/a | $85.15M | 0.2% | n/c | 1 | SEC ↗ |
| 23 | Arrowstreet Capital ✦ | 1.06M | +68.8% | $84.12M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 24 | UBS Group AG | 1.05M | n/a | $82.67M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 25 | Morgan Stanley ✦ | 1.02M | -13.6% | $80.68M | 0.0% | ▼ Trim | 2 | SEC ↗ ×15 |
| 26 | Nomura Holdings Inc | 871.00K | n/a | $68.90M | 0.2% | n/c | 1 | SEC ↗ ×3 |
| 27 | Nomura Asset Management… | 864.89K | n/a | $68.42M | 0.1% | n/c | 1 | SEC ↗ |
| 28 | Goldman Sachs Group ✦ | 855.97K | +10.1% | $67.72M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 29 | Northern Trust Corp | 846.72K | n/a | $66.98M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 30 | Barclays Plc | 842.87K | n/a | $66.68M | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 31 | Massachusetts Financial Services Co… | 812.75K | n/a | $64.30M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 32 | Bank Of America Corp /De/ | 783.58K | n/a | $61.99M | 0.0% | n/c | 1 | SEC ↗ ×11 |
| 33 | Td Asset Management Inc | 773.18K | n/a | $61.17M | 0.0% | n/c | 1 | SEC ↗ |
| 34 | Nuveen, LLC | 660.77K | n/a | $52.27M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 35 | Ameriprise Financial Inc | 598.75K | n/a | $47.37M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 36 | Bank of New York Mellon Corp | 753.89K | n/a | $42.85M | 0.0% | n/c | 1 | SEC ↗ ×15 |
| 37 | First Trust Advisors Lp | 525.24K | n/a | $41.55M | 0.0% | n/c | 1 | SEC ↗ |
| 38 | Alyeska Investment Group, L.P. | 481.71K | n/a | $38.11M | 0.1% | n/c | 1 | SEC ↗ |
| 39 | Amundi | 460.95K | n/a | $36.47M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 40 | Squarepoint Ops LLC | 436.28K | n/a | $34.51M | 0.1% | n/c | 1 | SEC ↗ |
| 41 | Corient Private Wealth LP | 431.37K | n/a | $34.13M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 42 | ARK Investment Management ✦ | 422.97K | -33.0% | $33.46M | 0.2% | ▼ Trim | 7 | SEC ↗ |
| 43 | Alliancebernstein L.P. | 341.85K | n/a | $27.04M | 0.0% | n/c | 1 | SEC ↗ |
| 44 | Bnp Paribas Financial Markets | 334.61K | n/a | $26.47M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 45 | D. E. Shaw & Co. ✦ | 332.80K | -47.2% | $26.33M | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 46 | Legal & General Group Plc | 325.15K | n/a | $25.72M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 47 | Norges Bank ✦ (passive) | 320.16K | New | $25.33M | 0.0% | New | 1 | SEC ↗ |
| 48 | Swiss National Bank | 298.50K | n/a | $23.61M | 0.0% | n/c | 1 | SEC ↗ |
| 49 | Focus Partners Wealth | 5.62M | n/a | $22.94M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 50 | Wells Fargo & Company/Mn | 280.05K | n/a | $22.15M | 0.0% | n/c | 1 | SEC ↗ ×8 |
| 51 | Raymond James Financial Inc | 257.21K | n/a | $20.35M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 52 | Marshall Wace ✦ | 256.93K | -73.2% | $20.33M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 53 | New York State Common Retirement… | 241.85K | n/a | $19.13M | 0.0% | n/c | 1 | SEC ↗ |
| 54 | Renaissance Technologies ✦ | 223.61K | -54.1% | $17.69M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 55 | Universal- Beteiligungs- und… | 219.57K | n/a | $17.37M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 56 | California Public Employees… | 213.37K | n/a | $16.88M | 0.0% | n/c | 1 | SEC ↗ |
| 57 | Stifel Financial Corp | 198.86K | n/a | $15.73M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 58 | Dimensional Fund Advisors Lp | 176.03K | n/a | $13.93M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 59 | Rhumbline Advisers | 175.39K | n/a | $13.87M | 0.0% | n/c | 1 | SEC ↗ |
| 60 | DZ BANK AG Deutsche Zentral… | 167.66K | n/a | $13.26M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 61 | Man Group plc | 166.04K | n/a | $13.14M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 62 | State Of Wisconsin Investment Board | 3.09M | n/a | $12.26M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 63 | Manufacturers Life Insurance… | 153.24K | n/a | $12.11M | 0.0% | n/c | 1 | SEC ↗ |
| 64 | Deutsche Bank Ag\ | 149.44K | n/a | $11.82M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 65 | California State Teachers… | 144.17K | n/a | $11.41M | 0.0% | n/c | 1 | SEC ↗ |
| 66 | Fisher Asset Management ✦ | 141.62K | +2180.4% | $11.20M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 67 | Adage Capital Partners ✦ | 140.00K | -89.3% | $11.08M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 68 | State Board Of Administration Of… | 135.88K | n/a | $10.75M | 0.0% | n/c | 1 | SEC ↗ |
| 69 | Balyasny Asset Management L.P. | 120.58K | n/a | $9.54M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 70 | Sei Investments Co | 220.92K | n/a | $9.34M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 71 | Healthcare Of Ontario Pension Plan… | 110.00K | n/a | $8.70M | 0.0% | n/c | 1 | SEC ↗ |
| 72 | Neuberger Berman Group LLC | 108.04K | n/a | $8.55M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 73 | Simplex Trading, Llc | 96.65K | n/a | $7.65M | 0.2% | n/c | 1 | SEC ↗ |
| 74 | Sumitomo Mitsui Trust Group, Inc. | 93.75K | n/a | $7.42M | 0.0% | n/c | 1 | SEC ↗ |
| 75 | Millennium Management ✦ | 93.26K | -88.0% | $7.38M | 0.0% | ▼ Trim | 7 | SEC ↗ ×3 |
| 76 | Envestnet Asset Management Inc | 89.92K | n/a | $7.11M | 0.0% | n/c | 1 | SEC ↗ |
| 77 | Citigroup Inc | 89.34K | n/a | $7.07M | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 78 | Victory Capital Management Inc | 80.73K | n/a | $6.39M | 0.0% | n/c | 1 | SEC ↗ |
| 79 | Voya Investment Management Llc | 73.76K | n/a | $5.84M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 80 | Janus Henderson Group Plc | 68.19K | n/a | $5.40M | 0.0% | n/c | 1 | SEC ↗ |
| 81 | Bridgewater Associates ✦ | 67.71K | +55.4% | $5.36M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 82 | Peak6 Llc | 61.28K | n/a | $4.85M | 0.1% | n/c | 1 | SEC ↗ ×2 |
| 83 | Creative Planning | 54.77K | n/a | $4.33M | 0.0% | n/c | 1 | SEC ↗ |
| 84 | Hsbc Holdings Plc | 53.88K | n/a | $4.28M | 0.0% | n/c | 1 | SEC ↗ ×10 |
| 85 | Ensign Peak Advisors, Inc | 53.66K | n/a | $4.25M | 0.0% | n/c | 1 | SEC ↗ |
| 86 | Zurcher Kantonalbank (Zurich… | 48.92K | n/a | $3.87M | 0.0% | n/c | 1 | SEC ↗ |
| 87 | Mariner, LLC | 47.74K | n/a | $3.78M | 0.0% | n/c | 1 | SEC ↗ |
| 88 | Quantinno Capital Management LP | 47.38K | n/a | $3.75M | 0.0% | n/c | 1 | SEC ↗ |
| 89 | Lazard Asset Management Llc | 46.40K | n/a | $3.67M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 90 | Russell Investments Group, Ltd. | 43.91K | n/a | $3.47M | 0.0% | n/c | 1 | SEC ↗ ×7 |
| 91 | Gotham Asset Management ✦ | 43.21K | +34.4% | $3.42M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 92 | Bank Of Montreal /Can/ | 36.36K | n/a | $2.88M | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 93 | Bamco Inc /Ny/ | 36.00K | n/a | $2.85M | 0.0% | n/c | 1 | SEC ↗ |
| 94 | Blair William & Co/Il | 33.79K | n/a | $2.67M | 0.0% | n/c | 1 | SEC ↗ |
| 95 | Susquehanna International Group, Llp | 32.50K | n/a | $2.57M | 0.0% | n/c | 1 | SEC ↗ |
| 96 | LPL Financial LLC | 31.07K | n/a | $2.46M | 0.0% | n/c | 1 | SEC ↗ |
| 97 | Jane Street Group, Llc | 30.47K | n/a | $2.41M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 98 | Assenagon Asset Management S.A. | 29.32K | n/a | $2.32M | 0.0% | n/c | 1 | SEC ↗ |
| 99 | Aberdeen Group plc | 28.93K | n/a | $2.29M | 0.0% | n/c | 1 | SEC ↗ |
| 100 | Swedbank AB | 27.25K | n/a | $2.16M | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| Norges Bank | $25.33M | 0.0% |
Exited
| No tracked exits this quarter. |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 490 holders, 170.17M shares, $11.94B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
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