IONS
Ionis Pharmaceuticals, Inc. · Healthcare · Biotechnology
Momentum inputs (comparable managers):
holder breadth -5.9% ·
share flow +7.4% ·
net new positions -6.2%
— formula
Concentrated accumulation — rising shares among fewer holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2024
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 139 | +2 | 148.59M | $11.08B | +6 | −3 |
| Q1 2026 | 139 | -2 | 142.62M | $9.86B | +6 | −9 |
| Q4 2025 | 142 | 0 | 143.10M | $10.36B | +1 | — |
| Q3 2025 | 25 | +4 | 95.56M | $6.25B | +5 | −2 |
| Q2 2025 | 19 | +1 | 95.25M | $3.76B | +1 | — |
| Q1 2025 | 15 | -1 | 43.90M | $1.32B | +1 | −2 |
| Q4 2024 | 16 | -1 | 43.25M | $1.51B | — | −1 |
| Q3 2024 | 16 | -1 | 34.86M | $1.40B | — | −1 |
| Q2 2024 | 17 | — | 24.68M | $1.18B | — | — |
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Capital World Investors ✦ | 11.47M | +46.5% | $400.83M | 0.1% | ▲ Add | 3 | SEC ↗ |
| 2 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 3 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 4 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 5 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 6 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 7 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 8 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 9 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 10 | Wellington Management ✦ | 8.67M | -0.7% | $303.18M | 0.1% | ▼ Trim | 3 | SEC ↗ |
| 11 | State Street Global Advisors ✦ (passive) | 5.43M | — | $189.71M | 0.0% | n/c | 1 | SEC ↗ |
| 12 | State Street Global Advisors ✦ (passive) | 5.43M | — | $189.71M | 0.0% | n/c | 1 | SEC ↗ |
| 13 | State Street Global Advisors ✦ (passive) | 5.43M | — | $189.71M | 0.0% | n/c | 1 | SEC ↗ |
| 14 | T. Rowe Price ✦ | 3.83M | -9.1% | $133.79M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 15 | T. Rowe Price ✦ | 3.83M | -9.1% | $133.79M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 16 | Tweedy, Browne ✦ | 3.25M | -6.0% | $113.58M | 7.7% | ▼ Trim | 3 | SEC ↗ |
| 17 | Geode Capital Management ✦ (passive) | 2.69M | +0.7% | $93.98M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 18 | Geode Capital Management ✦ (passive) | 2.69M | +0.7% | $93.98M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 19 | Citadel Advisors ✦ | 2.17M | +439.9% | $75.72M | 0.1% | ▲ Add | 3 | SEC ↗ |
| 20 | Citadel Advisors ✦ | 2.17M | +439.9% | $75.72M | 0.1% | ▲ Add | 3 | SEC ↗ |
| 21 | Norges Bank ✦ (passive) | 1.71M | -15.4% | $59.95M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 22 | ARK Investment Management ✦ | 1.03M | -25.9% | $35.84M | 0.3% | ▼ Trim | 3 | SEC ↗ |
| 23 | Two Sigma Investments ✦ | 921.44K | +0.3% | $32.21M | 0.1% | ▲ Add | 3 | SEC ↗ |
| 24 | Marshall Wace ✦ | 812.31K | -57.7% | $28.40M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 25 | Marshall Wace ✦ | 812.31K | -57.7% | $28.40M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 26 | Marshall Wace ✦ | 812.31K | -57.7% | $28.40M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 27 | Millennium Management ✦ | 774.22K | +79.8% | $27.07M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 28 | Adage Capital Partners ✦ | 275.00K | -45.0% | $9.61M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 29 | Renaissance Technologies ✦ | 205.51K | +7.9% | $7.18M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 30 | D. E. Shaw & Co. ✦ | 23.12K | -84.1% | $808,380 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 31 | D. E. Shaw & Co. ✦ | 23.12K | -84.1% | $808,380 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 32 | Gotham Asset Management ✦ | 6.26K | 0.0% | $218,850 | 0.0% | ▼ Trim | 3 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| No new tracked buyers this quarter. |
Exited
| Baillie Gifford | $1.59M | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 490 holders, 170.17M shares, $11.94B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.