Security record · archived quarter
ZYME
Zymeworks Inc. · Healthcare · Biotechnology
90Tracked holders
-1Δ holders
25.71MShares held
$677.12MReported value
+0New positions
−1Exits
Momentum inputs (comparable managers):
holder breadth -1.1% ·
share flow -2.6% ·
net new positions -1.1%
— formula
Broad distribution — falling shares and fewer holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 89 | -2 | 24.79M | $647.06M | +6 | −8 |
| Q1 2026 | 94 | +3 | 24.89M | $623.10M | +9 | −6 |
| Q4 2025 | 90 | -1 | 25.71M | $677.12M | — | −1 |
| Q3 2025 | 19 | +2 | 15.73M | $268.60M | +2 | −1 |
| Q2 2025 | 15 | +1 | 10.33M | $129.64M | +1 | — |
| Q1 2025 | 11 | 0 | 3.31M | $39.41M | +1 | −1 |
| Q4 2024 | 11 | -2 | 3.00M | $43.95M | — | −2 |
| Q3 2024 | 12 | +2 | 2.16M | $27.11M | +2 | — |
| Q2 2024 | 10 | — | 2.50M | $21.29M | — | — |
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 2 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 3 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 4 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 5 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 6 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 7 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 8 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 9 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 10 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 11 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 12 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 13 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 14 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 15 | BlackRock ✦ (passive) | 4.60M | +15.2% | $121.00M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 16 | Morgan Stanley ✦ | 2.59M | -34.9% | $68.28M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 17 | Morgan Stanley ✦ | 2.59M | -34.9% | $68.28M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 18 | Morgan Stanley ✦ | 2.59M | -34.9% | $68.28M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 19 | Morgan Stanley ✦ | 2.59M | -34.9% | $68.28M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 20 | Morgan Stanley ✦ | 2.59M | -34.9% | $68.28M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 21 | Morgan Stanley ✦ | 2.59M | -34.9% | $68.28M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 22 | The Vanguard Group ✦ (passive) | 2.33M | +8.1% | $61.32M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 23 | The Vanguard Group ✦ (passive) | 2.33M | +8.1% | $61.32M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 24 | The Vanguard Group ✦ (passive) | 2.33M | +8.1% | $61.32M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 25 | The Vanguard Group ✦ (passive) | 2.33M | +8.1% | $61.32M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 26 | The Vanguard Group ✦ (passive) | 2.33M | +8.1% | $61.32M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 27 | BNP Paribas Asset Management… | 1.82M | — | $47.98M | 0.1% | n/c | 1 | SEC ↗ |
| 28 | BNP Paribas Asset Management… | 1.82M | — | $47.98M | 0.1% | n/c | 1 | SEC ↗ |
| 29 | BNP Paribas Asset Management… | 1.82M | — | $47.98M | 0.1% | n/c | 1 | SEC ↗ |
| 30 | Deutsche Bank Ag\ | 1.60M | — | $42.02M | 0.0% | n/c | 1 | SEC ↗ |
| 31 | Deutsche Bank Ag\ | 1.60M | — | $42.02M | 0.0% | n/c | 1 | SEC ↗ |
| 32 | Deutsche Bank Ag\ | 1.60M | — | $42.02M | 0.0% | n/c | 1 | SEC ↗ |
| 33 | Deutsche Bank Ag\ | 1.60M | — | $42.02M | 0.0% | n/c | 1 | SEC ↗ |
| 34 | Dimensional Fund Advisors Lp | 1.16M | — | $30.52M | 0.0% | n/c | 1 | SEC ↗ |
| 35 | Dimensional Fund Advisors Lp | 1.16M | — | $30.52M | 0.0% | n/c | 1 | SEC ↗ |
| 36 | Dimensional Fund Advisors Lp | 1.16M | — | $30.52M | 0.0% | n/c | 1 | SEC ↗ |
| 37 | Dimensional Fund Advisors Lp | 1.16M | — | $30.52M | 0.0% | n/c | 1 | SEC ↗ |
| 38 | Dimensional Fund Advisors Lp | 1.16M | — | $30.52M | 0.0% | n/c | 1 | SEC ↗ |
| 39 | State Street Global Advisors ✦ (passive) | 1.04M | -4.0% | $27.32M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 40 | Arrowstreet Capital ✦ | 700.00K | +123.1% | $18.43M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 41 | Adage Capital Partners ✦ | 663.55K | +17.6% | $17.47M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 42 | Nuveen, LLC | 648.33K | — | $17.07M | 0.0% | n/c | 1 | SEC ↗ |
| 43 | Nuveen, LLC | 648.33K | — | $17.07M | 0.0% | n/c | 1 | SEC ↗ |
| 44 | Nuveen, LLC | 648.33K | — | $17.07M | 0.0% | n/c | 1 | SEC ↗ |
| 45 | Geode Capital Management ✦ (passive) | 647.97K | -4.5% | $17.06M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 46 | Geode Capital Management ✦ (passive) | 647.97K | -4.5% | $17.06M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 47 | Assenagon Asset Management S.A. | 647.37K | — | $17.05M | 0.0% | n/c | 1 | SEC ↗ |
| 48 | Fidelity (FMR) ✦ | 560.09K | +15838.7% | $14.75M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 49 | Fidelity (FMR) ✦ | 560.09K | +15838.7% | $14.75M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 50 | Qube Research & Technologies Ltd | 474.29K | — | $12.49M | 0.0% | n/c | 1 | SEC ↗ |
| 51 | Goldman Sachs Group ✦ | 420.21K | -5.3% | $11.06M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 52 | Goldman Sachs Group ✦ | 420.21K | -5.3% | $11.06M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 53 | Millennium Management ✦ | 381.62K | -65.5% | $10.05M | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 54 | UBS AM, a distinct business unit of… | 320.26K | — | $8.43M | 0.0% | n/c | 1 | SEC ↗ |
| 55 | UBS AM, a distinct business unit of… | 320.26K | — | $8.43M | 0.0% | n/c | 1 | SEC ↗ |
| 56 | UBS AM, a distinct business unit of… | 320.26K | — | $8.43M | 0.0% | n/c | 1 | SEC ↗ |
| 57 | UBS AM, a distinct business unit of… | 320.26K | — | $8.43M | 0.0% | n/c | 1 | SEC ↗ |
| 58 | UBS AM, a distinct business unit of… | 320.26K | — | $8.43M | 0.0% | n/c | 1 | SEC ↗ |
| 59 | Northern Trust Corp | 307.98K | — | $8.11M | 0.0% | n/c | 1 | SEC ↗ |
| 60 | Northern Trust Corp | 307.98K | — | $8.11M | 0.0% | n/c | 1 | SEC ↗ |
| 61 | Northern Trust Corp | 307.98K | — | $8.11M | 0.0% | n/c | 1 | SEC ↗ |
| 62 | Northern Trust Corp | 307.98K | — | $8.11M | 0.0% | n/c | 1 | SEC ↗ |
| 63 | Northern Trust Corp | 307.98K | — | $8.11M | 0.0% | n/c | 1 | SEC ↗ |
| 64 | Northern Trust Corp | 307.98K | — | $8.11M | 0.0% | n/c | 1 | SEC ↗ |
| 65 | UBS Group AG | 278.85K | — | $7.34M | 0.0% | n/c | 1 | SEC ↗ |
| 66 | UBS Group AG | 278.85K | — | $7.34M | 0.0% | n/c | 1 | SEC ↗ |
| 67 | Invesco Ltd. | 257.58K | — | $6.78M | 0.0% | n/c | 1 | SEC ↗ |
| 68 | Invesco Ltd. | 257.58K | — | $6.78M | 0.0% | n/c | 1 | SEC ↗ |
| 69 | Invesco Ltd. | 257.58K | — | $6.78M | 0.0% | n/c | 1 | SEC ↗ |
| 70 | Invesco Ltd. | 257.58K | — | $6.78M | 0.0% | n/c | 1 | SEC ↗ |
| 71 | Invesco Ltd. | 257.58K | — | $6.78M | 0.0% | n/c | 1 | SEC ↗ |
| 72 | Citadel Advisors ✦ | 255.35K | +23.4% | $6.72M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 73 | Citadel Advisors ✦ | 255.35K | +23.4% | $6.72M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 74 | D. E. Shaw & Co. ✦ | 223.79K | +76.3% | $5.89M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 75 | D. E. Shaw & Co. ✦ | 223.79K | +76.3% | $5.89M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 76 | Charles Schwab Investment… | 220.91K | — | $5.82M | 0.0% | n/c | 1 | SEC ↗ |
| 77 | Renaissance Technologies ✦ | 220.88K | -48.8% | $5.82M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 78 | Wells Fargo & Company/Mn | 208.31K | — | $5.48M | 0.0% | n/c | 1 | SEC ↗ |
| 79 | Wells Fargo & Company/Mn | 208.31K | — | $5.48M | 0.0% | n/c | 1 | SEC ↗ |
| 80 | Wells Fargo & Company/Mn | 208.31K | — | $5.48M | 0.0% | n/c | 1 | SEC ↗ |
| 81 | Raymond James Financial Inc | 187.69K | — | $4.94M | 0.0% | n/c | 1 | SEC ↗ |
| 82 | Raymond James Financial Inc | 187.69K | — | $4.94M | 0.0% | n/c | 1 | SEC ↗ |
| 83 | Raymond James Financial Inc | 187.69K | — | $4.94M | 0.0% | n/c | 1 | SEC ↗ |
| 84 | Wellington Management ✦ | 181.71K | +7.7% | $4.78M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 85 | Wellington Management ✦ | 181.71K | +7.7% | $4.78M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 86 | Wellington Management ✦ | 181.71K | +7.7% | $4.78M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 87 | Wellington Management ✦ | 181.71K | +7.7% | $4.78M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 88 | Wellington Management ✦ | 181.71K | +7.7% | $4.78M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 89 | Susquehanna International Group, Llp | 176.09K | — | $4.64M | 0.0% | n/c | 1 | SEC ↗ |
| 90 | Federated Hermes, Inc. | 152.69K | — | $4.02M | 0.0% | n/c | 1 | SEC ↗ |
| 91 | Federated Hermes, Inc. | 152.69K | — | $4.02M | 0.0% | n/c | 1 | SEC ↗ |
| 92 | Federated Hermes, Inc. | 152.69K | — | $4.02M | 0.0% | n/c | 1 | SEC ↗ |
| 93 | Bank of New York Mellon Corp | 128.13K | — | $3.37M | 0.0% | n/c | 1 | SEC ↗ |
| 94 | Bank of New York Mellon Corp | 128.13K | — | $3.37M | 0.0% | n/c | 1 | SEC ↗ |
| 95 | Bank of New York Mellon Corp | 128.13K | — | $3.37M | 0.0% | n/c | 1 | SEC ↗ |
| 96 | Bank of New York Mellon Corp | 128.13K | — | $3.37M | 0.0% | n/c | 1 | SEC ↗ |
| 97 | Bank of New York Mellon Corp | 128.13K | — | $3.37M | 0.0% | n/c | 1 | SEC ↗ |
| 98 | Hrt Financial Lp | 121.06K | — | $3.19M | 0.0% | n/c | 1 | SEC ↗ |
| 99 | Ameriprise Financial Inc | 113.14K | — | $2.98M | 0.0% | n/c | 1 | SEC ↗ |
| 100 | Ameriprise Financial Inc | 113.14K | — | $2.98M | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| No new tracked buyers this quarter. |
Exited
| Marshall Wace | $2.64M | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 209 holders, 70.12M shares, $1.75B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
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