Security record · archived quarter
UPB
Upstream Bio, Inc. · Healthcare · Biotechnology
64Tracked holders
+3Δ holders
24.32MShares held
$219.33MReported value
+14New positions
−12Exits
Momentum inputs (comparable managers):
holder breadth +4.9% ·
share flow +0.9% ·
net new positions +3.1%
· formula
Broad accumulation: rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q1 2026
Ownership over time
Who holds it · Q1 2026
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 8.10M | +7.8% | $72.91M | 0.0% | ▲ Add | 4 | SEC ↗ ×4 |
| 2 | BlackRock ✦ (passive) | 3.37M | +0.8% | $30.34M | 0.0% | ▲ Add | 4 | SEC ↗ ×13 |
| 3 | Vanguard Capital Management Llc | 1.87M | n/a | $16.86M | 0.0% | n/c | 1 | SEC ↗ |
| 4 | Federated Hermes, Inc. | 979.76K | +203169.3% | $8.82M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 5 | Geode Capital Management ✦ (passive) | 950.62K | +11.6% | $8.56M | 0.0% | ▲ Add | 6 | SEC ↗ ×2 |
| 6 | Millennium Management ✦ | 937.32K | +81.2% | $8.44M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 7 | D. E. Shaw & Co. ✦ | 820.48K | +2928.6% | $7.38M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 8 | Pictet Asset Management Holding SA | 733.43K | -5.1% | $6.60M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 9 | State Street Global Advisors ✦ (passive) | 705.35K | -46.5% | $6.35M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 10 | Hsbc Holdings Plc | 640.33K | New | $5.76M | 0.0% | New | 1 | SEC ↗ |
| 11 | Qube Research & Technologies Ltd | 619.32K | New | $5.57M | 0.0% | New | 1 | SEC ↗ |
| 12 | Morgan Stanley ✦ | 552.61K | +352.7% | $4.97M | 0.0% | ▲ Add | 3 | SEC ↗ ×6 |
| 13 | JPMorgan Chase ✦ | 463.00K | +319.8% | $4.07M | 0.0% | ▲ Add | 3 | SEC ↗ ×4 |
| 14 | Wellington Management ✦ | 342.35K | -61.7% | $3.08M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 15 | Goldman Sachs Group ✦ | 316.59K | -5.1% | $2.85M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 16 | Alyeska Investment Group, L.P. | 298.33K | 0.0% | $2.68M | 0.0% | Held | 2 | SEC ↗ |
| 17 | Northern Trust Corp | 260.99K | +10.2% | $2.35M | 0.0% | ▲ Add | 2 | SEC ↗ ×5 |
| 18 | Charles Schwab Investment… | 257.73K | -9.6% | $2.32M | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 19 | UBS Group AG | 231.25K | -87.2% | $2.08M | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 20 | Arrowstreet Capital ✦ | 185.09K | New | $1.67M | 0.0% | New | 1 | SEC ↗ |
| 21 | Deutsche Bank Ag\ | 180.89K | +41.5% | $1.63M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 22 | Point72 Asset Management ✦ | 178.17K | New | $1.60M | 0.0% | New | 1 | SEC ↗ |
| 23 | Bnp Paribas Financial Markets | 126.00K | +2432.2% | $1.13M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 24 | Alliancebernstein L.P. | 31.01K | 0.0% | $841,922 | 0.0% | Held | 2 | SEC ↗ |
| 25 | American Century Companies Inc | 87.62K | -0.1% | $788,616 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 26 | Bank of New York Mellon Corp | 81.38K | -4.1% | $732,447 | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 27 | Dimensional Fund Advisors Lp | 80.00K | New | $719,492 | 0.0% | New | 1 | SEC ↗ ×3 |
| 28 | Nuveen, LLC | 75.54K | -3.9% | $679,824 | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 29 | AQR Capital Management ✦ | 72.17K | +136.6% | $649,539 | 0.0% | ▲ Add | 5 | SEC ↗ ×5 |
| 30 | Marshall Wace ✦ | 66.77K | -80.6% | $600,930 | 0.0% | ▼ Trim | 6 | SEC ↗ ×2 |
| 31 | Renaissance Technologies ✦ | 62.10K | +278.7% | $558,900 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 32 | Quantinno Capital Management LP | 49.39K | +220.4% | $444,501 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 33 | Bank Of America Corp /De/ | 48.46K | -43.9% | $436,140 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 34 | Swiss National Bank | 48.10K | +80.8% | $432,900 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 35 | Squarepoint Ops LLC | 44.63K | New | $401,634 | 0.0% | New | 1 | SEC ↗ |
| 36 | State Of Wisconsin Investment Board | 41.67K | New | $375,039 | 0.0% | New | 1 | SEC ↗ |
| 37 | Rhumbline Advisers | 41.20K | -0.8% | $370,827 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 38 | Invesco Ltd. | 40.51K | -75.2% | $364,590 | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 39 | California State Teachers… | 39.66K | +170.7% | $356,949 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 40 | Mariner, LLC | 27.31K | +130.9% | $245,834 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 41 | T. Rowe Price ✦ | 26.43K | +34.6% | $238,000 | 0.0% | ▲ Add | 4 | SEC ↗ |
| 42 | Tudor Investment Corp Et Al | 26.41K | New | $237,708 | 0.0% | New | 1 | SEC ↗ |
| 43 | Victory Capital Management Inc | 25.87K | New | $232,794 | 0.0% | New | 1 | SEC ↗ |
| 44 | Barclays Plc | 24.72K | -95.3% | $222,480 | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 45 | Man Group plc | 21.15K | New | $190,386 | 0.0% | New | 1 | SEC ↗ |
| 46 | Wells Fargo & Company/Mn | 18.40K | -50.0% | $165,618 | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 47 | Susquehanna International Group, Llp | 15.96K | -71.4% | $143,649 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 48 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 15.61K | -10.8% | $140,472 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 49 | Manufacturers Life Insurance… | 15.34K | +51.2% | $138,042 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 50 | Franklin Resources Inc | 14.59K | New | $131,301 | 0.0% | New | 1 | SEC ↗ ×2 |
| 51 | Corient Private Wealth LP | 12.16K | New | $109,413 | 0.0% | New | 1 | SEC ↗ |
| 52 | Creative Planning | 10.85K | -7.7% | $97,650 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 53 | Legal & General Group Plc | 9.61K | -29.9% | $86,481 | 0.0% | ▼ Trim | 2 | SEC ↗ ×3 |
| 54 | Citigroup Inc | 5.05K | -27.3% | $45,495 | 0.0% | ▼ Trim | 2 | SEC ↗ ×2 |
| 55 | Cwm, Llc | 3.88K | +15.6% | $34,947 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 56 | Russell Investments Group, Ltd. | 3.65K | +29.2% | $32,823 | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 57 | Mirae Asset Global Investments Co.… | 2.82K | +7.3% | $25,371 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 58 | Rockefeller Capital Management L.P. | 738 | New | $6,642 | 0.0% | New | 1 | SEC ↗ |
| 59 | Us Bancorp \De\ | 590 | +8.1% | $5,310 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 60 | UBS AM, a distinct business unit of… | 588 | +143.0% | $5,292 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 61 | Zurcher Kantonalbank (Zurich… | 477 | New | $4,293 | 0.0% | New | 1 | SEC ↗ |
| 62 | Osaic Holdings, Inc. | 389 | +7680.0% | $3,501 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 63 | New York State Common Retirement… | 100 | -99.2% | $900 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 64 | Nomura Asset Management Co Ltd | 0 | n/a | $0 | 0.0% | Held | 2 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| Hsbc Holdings Plc | $5.76M | 0.0% |
| Qube Research & Technologies… | $5.57M | 0.0% |
| Arrowstreet Capital | $1.67M | 0.0% |
| Point72 Asset Management | $1.60M | 0.0% |
| Dimensional Fund Advisors Lp | $719,492 | 0.0% |
| Squarepoint Ops LLC | $401,634 | 0.0% |
| State Of Wisconsin Investment… | $375,039 | 0.0% |
| Tudor Investment Corp Et Al | $237,708 | 0.0% |
| Victory Capital Management Inc | $232,794 | 0.0% |
| Man Group plc | $190,386 | 0.0% |
| Franklin Resources Inc | $131,301 | 0.0% |
| Corient Private Wealth LP | $109,413 | 0.0% |
Exited
| Norges Bank | $78.26M | was 0.0% |
| Janus Henderson Group Plc | $41.42M | was 0.0% |
| Jennison Associates Llc | $7.84M | was 0.0% |
| Ameriprise Financial Inc | $1.54M | was 0.0% |
| Citadel Advisors | $364,353 | was 0.0% |
| Two Sigma Investments | $285,075 | was 0.0% |
| ProShare Advisors LLC | $226,811 | was 0.0% |
| Sei Investments Co | $219,562 | was 0.0% |
| Royal Bank Of Canada | $26,000 | was 0.0% |
| Simplex Trading, Llc | $12,651 | was 0.0% |
| Daiwa Securities Group Inc. | $5,000 | was 0.0% |
| Pnc Financial Services Group… | $2,877 | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 140 holders, 44.42M shares, $399.81M reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Sep 16
Ambrose Allison
Officer · 485 sh · $2,663
Sep 16
Deykin Aaron
Officer · 895 sh · $4,914
Sep 16
GRAY MICHAEL
Officer · 853 sh · $4,683
Sep 16
Houghton Adam
Officer · 700 sh · $3,843
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Aug 12
SC 13G/A: NORGES BANK
Jul 30
SC 13G: BlackRock, Inc.
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q1 2026 ·
Methodology ·
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