证券记录 · 已归档季度
UPB
Upstream Bio, Inc. · Healthcare · Biotechnology
62被追踪持有人
+3Δ持有人
27.51M持有股份
$746.80M报告持仓市值
+4新建仓位
−0清仓
动量输入（同类管理人）：
持有人广度 +5.1% ·
股份流向 +1.2% ·
净新建仓位 +6.5%
— 公式
广泛积累 — 持股数量上升且持有人增多
所有持股数据：仅限已追踪的 13F 管理人，普通股持仓，报告期 Q4 2025
持股变化趋势
| 季度 | 持有人 | Δ | 股份 | 报告持仓市值 | 新增 | 清仓 |
|---|---|---|---|---|---|---|
| Q2 2026 | 66 | +3 | 29.87M | $206.85M | +14 | −10 |
| Q1 2026 | 64 | +3 | 24.32M | $219.33M | +14 | −12 |
| Q4 2025 | 62 | +3 | 27.51M | $746.80M | +4 | — |
| Q3 2025 | 14 | +2 | 17.53M | $329.70M | +2 | −1 |
| Q2 2025 | 10 | -1 | 15.87M | $174.20M | +1 | −2 |
| Q1 2025 | 8 | +1 | 3.40M | $20.78M | +3 | −2 |
| Q4 2024 | 7 | +6 | 3.71M | $60.61M | +6 | — |
持有人 · Q4 2025
| # | 管理人 | 股份 | Δ股份 | 价值 | 其权重 | 持有 | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 7.52M | -7.0% | $204.12M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 2 | Fidelity (FMR) ✦ | 7.52M | -7.0% | $204.12M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 3 | Fidelity (FMR) ✦ | 7.52M | -7.0% | $204.12M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 4 | Fidelity (FMR) ✦ | 7.52M | -7.0% | $204.12M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 5 | Fidelity (FMR) ✦ | 7.52M | -7.0% | $204.12M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 6 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 7 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 8 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 9 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 10 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 11 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 12 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 13 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 14 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 15 | BlackRock ✦ (被动) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 16 | Norges Bank ✦ (被动) | 2.88M | 新增 | $78.26M | 0.0% | New | 1 | SEC ↗ |
| 17 | The Vanguard Group ✦ (被动) | 2.39M | -2.2% | $64.85M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 18 | The Vanguard Group ✦ (被动) | 2.39M | -2.2% | $64.85M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 19 | The Vanguard Group ✦ (被动) | 2.39M | -2.2% | $64.85M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 20 | The Vanguard Group ✦ (被动) | 2.39M | -2.2% | $64.85M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 21 | The Vanguard Group ✦ (被动) | 2.39M | -2.2% | $64.85M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 22 | UBS Group AG | 1.81M | — | $49.04M | 0.0% | n/c | 1 | SEC ↗ |
| 23 | UBS Group AG | 1.81M | — | $49.04M | 0.0% | n/c | 1 | SEC ↗ |
| 24 | Janus Henderson Group Plc | 1.53M | — | $41.42M | 0.0% | n/c | 1 | SEC ↗ |
| 25 | Janus Henderson Group Plc | 1.53M | — | $41.42M | 0.0% | n/c | 1 | SEC ↗ |
| 26 | State Street Global Advisors ✦ (被动) | 1.32M | +18.4% | $35.82M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 27 | Wellington Management ✦ | 894.73K | -20.5% | $24.29M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 28 | Geode Capital Management ✦ (被动) | 851.91K | +4.3% | $23.13M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 29 | Geode Capital Management ✦ (被动) | 851.91K | +4.3% | $23.13M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 30 | Pictet Asset Management Holding SA | 773.15K | — | $20.99M | 0.0% | n/c | 1 | SEC ↗ |
| 31 | Barclays Plc | 524.50K | — | $14.24M | 0.0% | n/c | 1 | SEC ↗ |
| 32 | Millennium Management ✦ | 517.26K | +1189.5% | $14.04M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 33 | Marshall Wace ✦ | 343.79K | -60.4% | $9.33M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 34 | Goldman Sachs Group ✦ | 333.48K | +49.4% | $9.05M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 35 | Alyeska Investment Group, L.P. | 298.33K | — | $8.10M | 0.0% | n/c | 1 | SEC ↗ |
| 36 | Jennison Associates Llc | 288.85K | — | $7.84M | 0.0% | n/c | 1 | SEC ↗ |
| 37 | Charles Schwab Investment… | 284.93K | — | $7.74M | 0.0% | n/c | 1 | SEC ↗ |
| 38 | Northern Trust Corp | 236.80K | — | $6.43M | 0.0% | n/c | 1 | SEC ↗ |
| 39 | Northern Trust Corp | 236.80K | — | $6.43M | 0.0% | n/c | 1 | SEC ↗ |
| 40 | Northern Trust Corp | 236.80K | — | $6.43M | 0.0% | n/c | 1 | SEC ↗ |
| 41 | Invesco Ltd. | 163.19K | — | $4.43M | 0.0% | n/c | 1 | SEC ↗ |
| 42 | Invesco Ltd. | 163.19K | — | $4.43M | 0.0% | n/c | 1 | SEC ↗ |
| 43 | Invesco Ltd. | 163.19K | — | $4.43M | 0.0% | n/c | 1 | SEC ↗ |
| 44 | Invesco Ltd. | 163.19K | — | $4.43M | 0.0% | n/c | 1 | SEC ↗ |
| 45 | Deutsche Bank Ag\ | 127.81K | — | $3.47M | 0.0% | n/c | 1 | SEC ↗ |
| 46 | Deutsche Bank Ag\ | 127.81K | — | $3.47M | 0.0% | n/c | 1 | SEC ↗ |
| 47 | Morgan Stanley ✦ | 122.07K | +39.5% | $3.31M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 48 | Morgan Stanley ✦ | 122.07K | +39.5% | $3.31M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 49 | Morgan Stanley ✦ | 122.07K | +39.5% | $3.31M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 50 | Morgan Stanley ✦ | 122.07K | +39.5% | $3.31M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 51 | Morgan Stanley ✦ | 122.07K | +39.5% | $3.31M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 52 | JPMorgan Chase ✦ | 110.28K | +84.1% | $2.99M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 53 | JPMorgan Chase ✦ | 110.28K | +84.1% | $2.99M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 54 | JPMorgan Chase ✦ | 110.28K | +84.1% | $2.99M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 55 | American Century Companies Inc | 87.76K | — | $2.38M | 0.0% | n/c | 1 | SEC ↗ |
| 56 | Bank Of America Corp /De/ | 86.38K | — | $2.35M | 0.0% | n/c | 1 | SEC ↗ |
| 57 | Bank Of America Corp /De/ | 86.38K | — | $2.35M | 0.0% | n/c | 1 | SEC ↗ |
| 58 | Bank Of America Corp /De/ | 86.38K | — | $2.35M | 0.0% | n/c | 1 | SEC ↗ |
| 59 | Bank of New York Mellon Corp | 84.85K | — | $2.30M | 0.0% | n/c | 1 | SEC ↗ |
| 60 | Bank of New York Mellon Corp | 84.85K | — | $2.30M | 0.0% | n/c | 1 | SEC ↗ |
| 61 | Bank of New York Mellon Corp | 84.85K | — | $2.30M | 0.0% | n/c | 1 | SEC ↗ |
| 62 | Nuveen, LLC | 78.57K | — | $2.13M | 0.0% | n/c | 1 | SEC ↗ |
| 63 | Nuveen, LLC | 78.57K | — | $2.13M | 0.0% | n/c | 1 | SEC ↗ |
| 64 | Ameriprise Financial Inc | 56.56K | — | $1.54M | 0.0% | n/c | 1 | SEC ↗ |
| 65 | Susquehanna International Group, Llp | 55.84K | — | $1.52M | 0.0% | n/c | 1 | SEC ↗ |
| 66 | Rhumbline Advisers | 41.52K | — | $1.13M | 0.0% | n/c | 1 | SEC ↗ |
| 67 | Wells Fargo & Company/Mn | 36.79K | — | $998,957 | 0.0% | n/c | 1 | SEC ↗ |
| 68 | Alliancebernstein L.P. | 31.01K | — | $841,922 | 0.0% | n/c | 1 | SEC ↗ |
| 69 | AQR Capital Management ✦ | 30.50K | +1.8% | $828,158 | 0.0% | ▲ Add | 4 | SEC ↗ |
| 70 | AQR Capital Management ✦ | 30.50K | +1.8% | $828,158 | 0.0% | ▲ Add | 4 | SEC ↗ |
| 71 | AQR Capital Management ✦ | 30.50K | +1.8% | $828,158 | 0.0% | ▲ Add | 4 | SEC ↗ |
| 72 | AQR Capital Management ✦ | 30.50K | +1.8% | $828,158 | 0.0% | ▲ Add | 4 | SEC ↗ |
| 73 | AQR Capital Management ✦ | 30.50K | +1.8% | $828,158 | 0.0% | ▲ Add | 4 | SEC ↗ |
| 74 | AQR Capital Management ✦ | 30.50K | +1.8% | $828,158 | 0.0% | ▲ Add | 4 | SEC ↗ |
| 75 | D. E. Shaw & Co. ✦ | 27.09K | 新增 | $735,521 | 0.0% | New | 1 | SEC ↗ |
| 76 | Swiss National Bank | 26.60K | — | $722,190 | 0.0% | n/c | 1 | SEC ↗ |
| 77 | T. Rowe Price ✦ | 19.64K | +6.1% | $534,000 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 78 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 17.49K | — | $475,264 | 0.0% | n/c | 1 | SEC ↗ |
| 79 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 17.49K | — | $475,264 | 0.0% | n/c | 1 | SEC ↗ |
| 80 | Renaissance Technologies ✦ | 16.40K | 新增 | $445,260 | 0.0% | New | 1 | SEC ↗ |
| 81 | Quantinno Capital Management LP | 15.41K | — | $418,517 | 0.0% | n/c | 1 | SEC ↗ |
| 82 | California State Teachers… | 14.65K | — | $397,802 | 0.0% | n/c | 1 | SEC ↗ |
| 83 | Legal & General Group Plc | 13.71K | — | $372,199 | 0.0% | n/c | 1 | SEC ↗ |
| 84 | Legal & General Group Plc | 13.71K | — | $372,199 | 0.0% | n/c | 1 | SEC ↗ |
| 85 | Legal & General Group Plc | 13.71K | — | $372,199 | 0.0% | n/c | 1 | SEC ↗ |
| 86 | Citadel Advisors ✦ | 13.42K | 新增 | $364,353 | 0.0% | New | 1 | SEC ↗ |
| 87 | Mariner, LLC | 11.83K | — | $321,174 | 0.0% | n/c | 1 | SEC ↗ |
| 88 | Creative Planning | 11.75K | — | $318,985 | 0.0% | n/c | 1 | SEC ↗ |
| 89 | New York State Common Retirement… | 11.70K | — | $317,655 | 0.0% | n/c | 1 | SEC ↗ |
| 90 | Two Sigma Investments ✦ | 10.50K | 0.0% | $285,075 | 0.0% | Held | 2 | SEC ↗ |
| 91 | Manufacturers Life Insurance… | 10.15K | — | $275,491 | 0.0% | n/c | 1 | SEC ↗ |
| 92 | ProShare Advisors LLC | 8.35K | — | $226,811 | 0.0% | n/c | 1 | SEC ↗ |
| 93 | Sei Investments Co | 8.09K | — | $219,562 | 0.0% | n/c | 1 | SEC ↗ |
| 94 | Citigroup Inc | 6.95K | — | $188,665 | 0.0% | n/c | 1 | SEC ↗ |
| 95 | Citigroup Inc | 6.95K | — | $188,665 | 0.0% | n/c | 1 | SEC ↗ |
| 96 | Bnp Paribas Financial Markets | 4.98K | — | $135,098 | 0.0% | n/c | 1 | SEC ↗ |
| 97 | Cwm, Llc | 3.36K | — | $91,000 | 0.0% | n/c | 1 | SEC ↗ |
| 98 | Russell Investments Group, Ltd. | 2.82K | — | $76,644 | 0.0% | n/c | 1 | SEC ↗ |
| 99 | Russell Investments Group, Ltd. | 2.82K | — | $76,644 | 0.0% | n/c | 1 | SEC ↗ |
| 100 | Mirae Asset Global Investments Co.… | 2.63K | — | $71,296 | 0.0% | n/c | 1 | SEC ↗ |
"持仓权重"= 该持仓占该管理人已申报13F股权价值的比例——即信念度衡量指标。✦ = 精选管理人。
新增买入方
| Norges Bank | $78.26M | 0.0% |
| D. E. Shaw & Co. | $735,521 | 0.0% |
| Renaissance Technologies | $445,260 | 0.0% |
| Citadel Advisors | $364,353 | 0.0% |
已清仓
| 本季度无被追踪的退出仓位。 |
全市场背景: 涵盖所有13F申报机构（SEC结构化数据， Q1 2026): 140 持有人, 44.42M 股份, $399.81M 已申报. 这是与上方被追踪全域数据不同的较早期间，两者从不混用。
常见共同持仓
该证券的被追踪持有人最常同时持有的其他证券——基于共同持有计数，而非基本面关联。
数据来源: 持股数据来源于已解析的13F普通股持仓（被追踪范围，变动对比集）；内部人行为来自Form 3/4/5；重大持股来自Schedule 13D/13G；所有文件均链接至SEC EDGAR原始申报。
报告期: Q4 2025 ·
方法论 ·
通过API获取此数据