证券记录 · 已归档季度

UPB

Upstream Bio, Inc. · Healthcare · Biotechnology

2.82 +0.7% 市值 $154.45M 报价延迟（FMP） · 截至 Oct 20 22:08 UTC · 与下方申报数据相互独立

Q2 2026 Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024

62被追踪持有人

+3Δ持有人

27.51M持有股份

$746.80M报告持仓市值

+4新建仓位

−0清仓

Rising 3 被追踪股份持续上升的季度数 ●●●○○○ 计算方式说明 → 在研究台查询相关说明 →

动量输入（同类管理人）：持有人广度 +5.1% · 股份流向 +1.2% · 净新建仓位 +6.5% · 公式
广泛增持：持股数量上升，持有人数量增加

所有持股数据：仅限已追踪的 13F 管理人，普通股持仓，报告期 Q4 2025

持股变化趋势

季度	持有人	Δ	股份	报告持仓市值	新增	清仓
Q2 2026	66	+3	29.87M	$206.85M	+14	−10
Q1 2026	64	+3	24.32M	$219.33M	+14	−12
Q4 2025	62	+3	27.51M	$746.80M	+4	n/a
Q3 2025	14	+2	17.53M	$329.70M	+2	−1
Q2 2025	10	-1	15.87M	$174.20M	+1	−2
Q1 2025	8	+1	3.40M	$20.78M	+3	−2
Q4 2024	7	+6	3.71M	$60.61M	+6	n/a

持有人数量

持有人 · Q4 2025

#	管理人	股份	Δ股份	价值	其权重		持有
1	Fidelity (FMR) ✦	7.52M	-7.0%	$204.12M	0.0%	▼ Trim	3	SEC ↗ ×5
2	BlackRock ✦ (被动)	3.34M	+28.4%	$90.80M	0.0%	▲ Add	3	SEC ↗ ×10
3	Norges Bank ✦ (被动)	2.88M	新增	$78.26M	0.0%	New	1	SEC ↗
4	The Vanguard Group ✦ (被动)	2.39M	-2.2%	$64.85M	0.0%	▼ Trim	3	SEC ↗ ×5
5	UBS Group AG	1.81M	n/a	$49.04M	0.0%	n/c	1	SEC ↗ ×2
6	Janus Henderson Group Plc	1.53M	n/a	$41.42M	0.0%	n/c	1	SEC ↗ ×2
7	State Street Global Advisors ✦ (被动)	1.32M	+18.4%	$35.82M	0.0%	▲ Add	5	SEC ↗
8	Wellington Management ✦	894.73K	-20.5%	$24.29M	0.0%	▼ Trim	5	SEC ↗
9	Geode Capital Management ✦ (被动)	851.91K	+4.3%	$23.13M	0.0%	▲ Add	5	SEC ↗ ×2
10	Pictet Asset Management Holding SA	773.15K	n/a	$20.99M	0.0%	n/c	1	SEC ↗
11	Barclays Plc	524.50K	n/a	$14.24M	0.0%	n/c	1	SEC ↗
12	Millennium Management ✦	517.26K	+1189.5%	$14.04M	0.0%	▲ Add	2	SEC ↗
13	Marshall Wace ✦	343.79K	-60.4%	$9.33M	0.0%	▼ Trim	5	SEC ↗
14	Goldman Sachs Group ✦	333.48K	+49.4%	$9.05M	0.0%	▲ Add	2	SEC ↗
15	Alyeska Investment Group, L.P.	298.33K	n/a	$8.10M	0.0%	n/c	1	SEC ↗
16	Jennison Associates Llc	288.85K	n/a	$7.84M	0.0%	n/c	1	SEC ↗
17	Charles Schwab Investment…	284.93K	n/a	$7.74M	0.0%	n/c	1	SEC ↗
18	Northern Trust Corp	236.80K	n/a	$6.43M	0.0%	n/c	1	SEC ↗ ×3
19	Invesco Ltd.	163.19K	n/a	$4.43M	0.0%	n/c	1	SEC ↗ ×4
20	Deutsche Bank Ag\	127.81K	n/a	$3.47M	0.0%	n/c	1	SEC ↗ ×2
21	Morgan Stanley ✦	122.07K	+39.5%	$3.31M	0.0%	▲ Add	2	SEC ↗ ×5
22	JPMorgan Chase ✦	110.28K	+84.1%	$2.99M	0.0%	▲ Add	2	SEC ↗ ×3
23	American Century Companies Inc	87.76K	n/a	$2.38M	0.0%	n/c	1	SEC ↗
24	Bank Of America Corp /De/	86.38K	n/a	$2.35M	0.0%	n/c	1	SEC ↗ ×3
25	Bank of New York Mellon Corp	84.85K	n/a	$2.30M	0.0%	n/c	1	SEC ↗ ×3
26	Nuveen, LLC	78.57K	n/a	$2.13M	0.0%	n/c	1	SEC ↗ ×2
27	Ameriprise Financial Inc	56.56K	n/a	$1.54M	0.0%	n/c	1	SEC ↗
28	Susquehanna International Group, Llp	55.84K	n/a	$1.52M	0.0%	n/c	1	SEC ↗
29	Rhumbline Advisers	41.52K	n/a	$1.13M	0.0%	n/c	1	SEC ↗
30	Wells Fargo & Company/Mn	36.79K	n/a	$998,957	0.0%	n/c	1	SEC ↗
31	Alliancebernstein L.P.	31.01K	n/a	$841,922	0.0%	n/c	1	SEC ↗
32	AQR Capital Management ✦	30.50K	+1.8%	$828,158	0.0%	▲ Add	4	SEC ↗ ×6
33	D. E. Shaw & Co. ✦	27.09K	新增	$735,521	0.0%	New	1	SEC ↗
34	Swiss National Bank	26.60K	n/a	$722,190	0.0%	n/c	1	SEC ↗
35	T. Rowe Price ✦	19.64K	+6.1%	$534,000	0.0%	▲ Add	3	SEC ↗
36	MIRAE ASSET GLOBAL ETFS HOLDINGS…	17.49K	n/a	$475,264	0.0%	n/c	1	SEC ↗ ×2
37	Renaissance Technologies ✦	16.40K	新增	$445,260	0.0%	New	1	SEC ↗
38	Quantinno Capital Management LP	15.41K	n/a	$418,517	0.0%	n/c	1	SEC ↗
39	California State Teachers…	14.65K	n/a	$397,802	0.0%	n/c	1	SEC ↗
40	Legal & General Group Plc	13.71K	n/a	$372,199	0.0%	n/c	1	SEC ↗ ×3
41	Citadel Advisors ✦	13.42K	新增	$364,353	0.0%	New	1	SEC ↗
42	Mariner, LLC	11.83K	n/a	$321,174	0.0%	n/c	1	SEC ↗
43	Creative Planning	11.75K	n/a	$318,985	0.0%	n/c	1	SEC ↗
44	New York State Common Retirement…	11.70K	n/a	$317,655	0.0%	n/c	1	SEC ↗
45	Two Sigma Investments ✦	10.50K	0.0%	$285,075	0.0%	Held	2	SEC ↗
46	Manufacturers Life Insurance…	10.15K	n/a	$275,491	0.0%	n/c	1	SEC ↗
47	ProShare Advisors LLC	8.35K	n/a	$226,811	0.0%	n/c	1	SEC ↗
48	Sei Investments Co	8.09K	n/a	$219,562	0.0%	n/c	1	SEC ↗
49	Citigroup Inc	6.95K	n/a	$188,665	0.0%	n/c	1	SEC ↗ ×2
50	Bnp Paribas Financial Markets	4.98K	n/a	$135,098	0.0%	n/c	1	SEC ↗
51	Cwm, Llc	3.36K	n/a	$91,000	0.0%	n/c	1	SEC ↗
52	Russell Investments Group, Ltd.	2.82K	n/a	$76,644	0.0%	n/c	1	SEC ↗ ×2
53	Mirae Asset Global Investments Co.…	2.63K	n/a	$71,296	0.0%	n/c	1	SEC ↗
54	Royal Bank Of Canada	969	n/a	$26,000	0.0%	n/c	1	SEC ↗ ×3
55	Us Bancorp \De\	546	n/a	$14,824	0.0%	n/c	1	SEC ↗
56	Federated Hermes, Inc.	482	n/a	$13,086	0.0%	n/c	1	SEC ↗
57	Simplex Trading, Llc	466	n/a	$12,651	0.0%	n/c	1	SEC ↗
58	UBS AM, a distinct business unit of…	242	n/a	$6,570	0.0%	n/c	1	SEC ↗
59	Daiwa Securities Group Inc.	180	n/a	$5,000	0.0%	n/c	1	SEC ↗
60	Pnc Financial Services Group, Inc.	106	n/a	$2,877	0.0%	n/c	1	SEC ↗ ×3
61	Osaic Holdings, Inc.	5	n/a	$136	0.0%	n/c	1	SEC ↗
62	Nomura Asset Management Co Ltd	0	n/a	$0	0.0%	n/c	1	SEC ↗

"持仓权重"指该仓位占该管理人13F申报股票组合市值的比例，即持仓信心指标。✦ = 精选管理人。

新增买入方

Norges Bank	$78.26M	0.0%
D. E. Shaw & Co.	$735,521	0.0%
Renaissance Technologies	$445,260	0.0%
Citadel Advisors	$364,353	0.0%

已清仓

本季度无被追踪的退出仓位。

全市场背景: 涵盖所有13F申报机构（SEC结构化数据， Q1 2026): 140 持有人, 44.42M 股份, $399.81M 已申报. 这是与上方被追踪全域数据不同的较早期间，两者从不混用。

常见共同持仓

持有该证券的受追踪机构最常同时持有的其他证券：基于共同持有计数，而非基本面关联。

HLT62共同持有人 LNG62共同持有人 GH62共同持有人 MSFT62共同持有人 BSX62共同持有人

内部人交易

公开市场买入 (P)

在我们的覆盖窗口内无内部人士公开市场买入记录。

公开市场卖出 (S)

Sep 16 Ambrose Allison

Officer · 485 股 · $2,663

Sep 16 Deykin Aaron

Officer · 895 股 · $4,914

Sep 16 GRAY MICHAEL

Officer · 853 股 · $4,683

Sep 16 Houghton Adam

Officer · 700 股 · $3,843

授予、行权及税务代扣代缴在本平台均不计入买入或卖出。方法论

受益所有权

Aug 12 SC 13G/A: NORGES BANK

查看 SEC 原始申报文件 ↗

Jul 30 SC 13G: BlackRock, Inc.

查看 SEC 原始申报文件 ↗

数据来源: 持股数据来源于已解析的13F普通股持仓（被追踪范围，变动对比集）；内部人行为来自Form 3/4/5；重大持股来自Schedule 13D/13G；所有文件均链接至SEC EDGAR原始申报。报告期: Q4 2025 · 方法论 · 通过API获取此数据

☆ UPB

新增买入方

已清仓

公开市场买入 (P)

公开市场卖出 (S)

UPB