Security record · archived quarter
UPB
Upstream Bio, Inc. · Healthcare · Biotechnology
62Tracked holders
+3Δ holders
27.51MShares held
$746.80MReported value
+4New positions
−0Exits
Momentum inputs (comparable managers):
holder breadth +5.1% ·
share flow +1.2% ·
net new positions +6.5%
· formula
Broad accumulation: rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 7.52M | -7.0% | $204.12M | 0.0% | ▼ Trim | 3 | SEC ↗ ×5 |
| 2 | BlackRock ✦ (passive) | 3.34M | +28.4% | $90.80M | 0.0% | ▲ Add | 3 | SEC ↗ ×10 |
| 3 | Norges Bank ✦ (passive) | 2.88M | New | $78.26M | 0.0% | New | 1 | SEC ↗ |
| 4 | The Vanguard Group ✦ (passive) | 2.39M | -2.2% | $64.85M | 0.0% | ▼ Trim | 3 | SEC ↗ ×5 |
| 5 | UBS Group AG | 1.81M | n/a | $49.04M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 6 | Janus Henderson Group Plc | 1.53M | n/a | $41.42M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 7 | State Street Global Advisors ✦ (passive) | 1.32M | +18.4% | $35.82M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 8 | Wellington Management ✦ | 894.73K | -20.5% | $24.29M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 9 | Geode Capital Management ✦ (passive) | 851.91K | +4.3% | $23.13M | 0.0% | ▲ Add | 5 | SEC ↗ ×2 |
| 10 | Pictet Asset Management Holding SA | 773.15K | n/a | $20.99M | 0.0% | n/c | 1 | SEC ↗ |
| 11 | Barclays Plc | 524.50K | n/a | $14.24M | 0.0% | n/c | 1 | SEC ↗ |
| 12 | Millennium Management ✦ | 517.26K | +1189.5% | $14.04M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 13 | Marshall Wace ✦ | 343.79K | -60.4% | $9.33M | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 14 | Goldman Sachs Group ✦ | 333.48K | +49.4% | $9.05M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 15 | Alyeska Investment Group, L.P. | 298.33K | n/a | $8.10M | 0.0% | n/c | 1 | SEC ↗ |
| 16 | Jennison Associates Llc | 288.85K | n/a | $7.84M | 0.0% | n/c | 1 | SEC ↗ |
| 17 | Charles Schwab Investment… | 284.93K | n/a | $7.74M | 0.0% | n/c | 1 | SEC ↗ |
| 18 | Northern Trust Corp | 236.80K | n/a | $6.43M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 19 | Invesco Ltd. | 163.19K | n/a | $4.43M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 20 | Deutsche Bank Ag\ | 127.81K | n/a | $3.47M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 21 | Morgan Stanley ✦ | 122.07K | +39.5% | $3.31M | 0.0% | ▲ Add | 2 | SEC ↗ ×5 |
| 22 | JPMorgan Chase ✦ | 110.28K | +84.1% | $2.99M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 23 | American Century Companies Inc | 87.76K | n/a | $2.38M | 0.0% | n/c | 1 | SEC ↗ |
| 24 | Bank Of America Corp /De/ | 86.38K | n/a | $2.35M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 25 | Bank of New York Mellon Corp | 84.85K | n/a | $2.30M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 26 | Nuveen, LLC | 78.57K | n/a | $2.13M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 27 | Ameriprise Financial Inc | 56.56K | n/a | $1.54M | 0.0% | n/c | 1 | SEC ↗ |
| 28 | Susquehanna International Group, Llp | 55.84K | n/a | $1.52M | 0.0% | n/c | 1 | SEC ↗ |
| 29 | Rhumbline Advisers | 41.52K | n/a | $1.13M | 0.0% | n/c | 1 | SEC ↗ |
| 30 | Wells Fargo & Company/Mn | 36.79K | n/a | $998,957 | 0.0% | n/c | 1 | SEC ↗ |
| 31 | Alliancebernstein L.P. | 31.01K | n/a | $841,922 | 0.0% | n/c | 1 | SEC ↗ |
| 32 | AQR Capital Management ✦ | 30.50K | +1.8% | $828,158 | 0.0% | ▲ Add | 4 | SEC ↗ ×6 |
| 33 | D. E. Shaw & Co. ✦ | 27.09K | New | $735,521 | 0.0% | New | 1 | SEC ↗ |
| 34 | Swiss National Bank | 26.60K | n/a | $722,190 | 0.0% | n/c | 1 | SEC ↗ |
| 35 | T. Rowe Price ✦ | 19.64K | +6.1% | $534,000 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 36 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 17.49K | n/a | $475,264 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 37 | Renaissance Technologies ✦ | 16.40K | New | $445,260 | 0.0% | New | 1 | SEC ↗ |
| 38 | Quantinno Capital Management LP | 15.41K | n/a | $418,517 | 0.0% | n/c | 1 | SEC ↗ |
| 39 | California State Teachers… | 14.65K | n/a | $397,802 | 0.0% | n/c | 1 | SEC ↗ |
| 40 | Legal & General Group Plc | 13.71K | n/a | $372,199 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 41 | Citadel Advisors ✦ | 13.42K | New | $364,353 | 0.0% | New | 1 | SEC ↗ |
| 42 | Mariner, LLC | 11.83K | n/a | $321,174 | 0.0% | n/c | 1 | SEC ↗ |
| 43 | Creative Planning | 11.75K | n/a | $318,985 | 0.0% | n/c | 1 | SEC ↗ |
| 44 | New York State Common Retirement… | 11.70K | n/a | $317,655 | 0.0% | n/c | 1 | SEC ↗ |
| 45 | Two Sigma Investments ✦ | 10.50K | 0.0% | $285,075 | 0.0% | Held | 2 | SEC ↗ |
| 46 | Manufacturers Life Insurance… | 10.15K | n/a | $275,491 | 0.0% | n/c | 1 | SEC ↗ |
| 47 | ProShare Advisors LLC | 8.35K | n/a | $226,811 | 0.0% | n/c | 1 | SEC ↗ |
| 48 | Sei Investments Co | 8.09K | n/a | $219,562 | 0.0% | n/c | 1 | SEC ↗ |
| 49 | Citigroup Inc | 6.95K | n/a | $188,665 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 50 | Bnp Paribas Financial Markets | 4.98K | n/a | $135,098 | 0.0% | n/c | 1 | SEC ↗ |
| 51 | Cwm, Llc | 3.36K | n/a | $91,000 | 0.0% | n/c | 1 | SEC ↗ |
| 52 | Russell Investments Group, Ltd. | 2.82K | n/a | $76,644 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 53 | Mirae Asset Global Investments Co.… | 2.63K | n/a | $71,296 | 0.0% | n/c | 1 | SEC ↗ |
| 54 | Royal Bank Of Canada | 969 | n/a | $26,000 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 55 | Us Bancorp \De\ | 546 | n/a | $14,824 | 0.0% | n/c | 1 | SEC ↗ |
| 56 | Federated Hermes, Inc. | 482 | n/a | $13,086 | 0.0% | n/c | 1 | SEC ↗ |
| 57 | Simplex Trading, Llc | 466 | n/a | $12,651 | 0.0% | n/c | 1 | SEC ↗ |
| 58 | UBS AM, a distinct business unit of… | 242 | n/a | $6,570 | 0.0% | n/c | 1 | SEC ↗ |
| 59 | Daiwa Securities Group Inc. | 180 | n/a | $5,000 | 0.0% | n/c | 1 | SEC ↗ |
| 60 | Pnc Financial Services Group, Inc. | 106 | n/a | $2,877 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 61 | Osaic Holdings, Inc. | 5 | n/a | $136 | 0.0% | n/c | 1 | SEC ↗ |
| 62 | Nomura Asset Management Co Ltd | 0 | n/a | $0 | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| Norges Bank | $78.26M | 0.0% |
| D. E. Shaw & Co. | $735,521 | 0.0% |
| Renaissance Technologies | $445,260 | 0.0% |
| Citadel Advisors | $364,353 | 0.0% |
Exited
| No tracked exits this quarter. |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 140 holders, 44.42M shares, $399.81M reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Sep 16
Ambrose Allison
Officer · 485 sh · $2,663
Sep 16
Deykin Aaron
Officer · 895 sh · $4,914
Sep 16
GRAY MICHAEL
Officer · 853 sh · $4,683
Sep 16
Houghton Adam
Officer · 700 sh · $3,843
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Aug 12
SC 13G/A: NORGES BANK
Jul 30
SC 13G: BlackRock, Inc.
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
Get this via the API