Security record
SEPN
Septerna Inc · Healthcare · Biotechnology
69Tracked holders
+20Δ holders
12.16MShares held
$407.03MReported value
+22New positions
−2Exits
Momentum inputs (comparable managers):
holder breadth +30.0% ·
share flow +17.6% ·
net new positions +20.0%
— formula
Broad accumulation — rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q2 2026
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 69 | +20 | 12.16M | $407.03M | +22 | −2 |
| Q1 2026 | 52 | -1 | 11.23M | $269.91M | +8 | −9 |
| Q4 2025 | 53 | +4 | 9.79M | $272.84M | +4 | — |
| Q3 2025 | 11 | -1 | 5.98M | $112.43M | — | −1 |
| Q2 2025 | 9 | +1 | 3.84M | $40.57M | +1 | — |
| Q1 2025 | 5 | -1 | 1.29M | $7.46M | +2 | −3 |
| Q4 2024 | 6 | +5 | 1.89M | $43.21M | +5 | — |
Who holds it · Q2 2026
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Goldman Sachs Group ✦ | 3.06M | +5.4% | $102.57M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 2 | Goldman Sachs Group ✦ | 3.06M | +5.4% | $102.57M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 3 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 4 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 5 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 6 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 7 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 8 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 9 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 10 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 11 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 12 | BlackRock ✦ (passive) | 1.93M | +6.0% | $64.71M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 13 | Vanguard Capital Management Llc | 1.22M | +2.1% | $40.91M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 14 | PRIMECAP Management ✦ | 1.17M | +11.3% | $39.10M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 15 | Geode Capital Management ✦ (passive) | 679.16K | +5.3% | $22.75M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 16 | Geode Capital Management ✦ (passive) | 679.16K | +5.3% | $22.75M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 17 | State Street Global Advisors ✦ (passive) | 652.63K | +3.4% | $21.86M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 18 | Loomis Sayles & Co L P | 624.75K | New | $20.92M | 0.0% | New | 1 | SEC ↗ |
| 19 | Loomis Sayles & Co L P | 624.75K | New | $20.92M | 0.0% | New | 1 | SEC ↗ |
| 20 | Balyasny Asset Management L.P. | 350.44K | +48.1% | $11.74M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 21 | Universal- Beteiligungs- und… | 222.70K | -0.6% | $7.46M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 22 | Two Sigma Investments ✦ | 220.88K | +193.1% | $7.40M | 0.0% | ▲ Add | 6 | SEC ↗ |
| 23 | Northern Trust Corp | 201.13K | +22.2% | $6.74M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 24 | Northern Trust Corp | 201.13K | +22.2% | $6.74M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 25 | Northern Trust Corp | 201.13K | +22.2% | $6.74M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 26 | Northern Trust Corp | 201.13K | +22.2% | $6.74M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 27 | Northern Trust Corp | 201.13K | +22.2% | $6.74M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 28 | Charles Schwab Investment… | 187.04K | +3.0% | $6.26M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 29 | Morgan Stanley ✦ | 134.38K | +21.6% | $4.50M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 30 | Morgan Stanley ✦ | 134.38K | +21.6% | $4.50M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 31 | Morgan Stanley ✦ | 134.38K | +21.6% | $4.50M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 32 | Morgan Stanley ✦ | 134.38K | +21.6% | $4.50M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 33 | Morgan Stanley ✦ | 134.38K | +21.6% | $4.50M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 34 | Morgan Stanley ✦ | 134.38K | +21.6% | $4.50M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 35 | UBS Group AG | 89.87K | -23.2% | $3.01M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 36 | UBS Group AG | 89.87K | -23.2% | $3.01M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 37 | JPMorgan Chase ✦ | 85.30K | +0.7% | $2.96M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 38 | JPMorgan Chase ✦ | 85.30K | +0.7% | $2.96M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 39 | JPMorgan Chase ✦ | 85.30K | +0.7% | $2.96M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 40 | JPMorgan Chase ✦ | 85.30K | +0.7% | $2.96M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 41 | Federated Hermes, Inc. | 86.75K | -2.9% | $2.91M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 42 | Federated Hermes, Inc. | 86.75K | -2.9% | $2.91M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 43 | Federated Hermes, Inc. | 86.75K | -2.9% | $2.91M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 44 | Lazard Asset Management Llc | 75.42K | New | $2.53M | 0.0% | New | 1 | SEC ↗ |
| 45 | Dimensional Fund Advisors Lp | 75.31K | New | $2.52M | 0.0% | New | 1 | SEC ↗ |
| 46 | Dimensional Fund Advisors Lp | 75.31K | New | $2.52M | 0.0% | New | 1 | SEC ↗ |
| 47 | Dimensional Fund Advisors Lp | 75.31K | New | $2.52M | 0.0% | New | 1 | SEC ↗ |
| 48 | Dimensional Fund Advisors Lp | 75.31K | New | $2.52M | 0.0% | New | 1 | SEC ↗ |
| 49 | Arrowstreet Capital ✦ | 74.65K | New | $2.50M | 0.0% | New | 1 | SEC ↗ |
| 50 | American Century Companies Inc | 60.97K | -0.5% | $2.04M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 51 | Bank of New York Mellon Corp | 56.18K | -4.3% | $1.88M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 52 | Bank of New York Mellon Corp | 56.18K | -4.3% | $1.88M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 53 | Bank of New York Mellon Corp | 56.18K | -4.3% | $1.88M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 54 | Bank of New York Mellon Corp | 56.18K | -4.3% | $1.88M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 55 | Bank of New York Mellon Corp | 56.18K | -4.3% | $1.88M | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 56 | Millennium Management ✦ | 50.56K | -59.3% | $1.69M | 0.0% | ▼ Trim | 6 | SEC ↗ |
| 57 | Barclays Plc | 49.82K | +119.3% | $1.67M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 58 | Barclays Plc | 49.82K | +119.3% | $1.67M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 59 | Nuveen, LLC | 48.23K | +65.3% | $1.62M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 60 | Nuveen, LLC | 48.23K | +65.3% | $1.62M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 61 | D. E. Shaw & Co. ✦ | 46.48K | New | $1.56M | 0.0% | New | 1 | SEC ↗ |
| 62 | Jane Street Group, Llc | 45.55K | New | $1.53M | 0.0% | New | 1 | SEC ↗ |
| 63 | Jane Street Group, Llc | 45.55K | New | $1.53M | 0.0% | New | 1 | SEC ↗ |
| 64 | Hrt Financial Lp | 42.02K | New | $1.41M | 0.0% | New | 1 | SEC ↗ |
| 65 | Renaissance Technologies ✦ | 41.42K | +9.9% | $1.39M | 0.0% | ▲ Add | 2 | SEC ↗ |
| 66 | Russell Investments Group, Ltd. | 40.21K | +249.2% | $1.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 67 | Russell Investments Group, Ltd. | 40.21K | +249.2% | $1.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 68 | Russell Investments Group, Ltd. | 40.21K | +249.2% | $1.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 69 | Russell Investments Group, Ltd. | 40.21K | +249.2% | $1.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 70 | Russell Investments Group, Ltd. | 40.21K | +249.2% | $1.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 71 | Russell Investments Group, Ltd. | 40.21K | +249.2% | $1.35M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 72 | Bank Of America Corp /De/ | 35.88K | +38.1% | $1.20M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 73 | T. Rowe Price ✦ | 35.32K | +25.8% | $1.18M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 74 | Alyeska Investment Group, L.P. | 35.00K | 0.0% | $1.17M | 0.0% | Held | 3 | SEC ↗ |
| 75 | Tudor Investment Corp Et Al | 28.97K | New | $970,071 | 0.0% | New | 1 | SEC ↗ |
| 76 | Rhumbline Advisers | 27.64K | +3.9% | $925,521 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 77 | Invesco Ltd. | 24.09K | -70.9% | $806,908 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 78 | Invesco Ltd. | 24.09K | -70.9% | $806,908 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 79 | Invesco Ltd. | 24.09K | -70.9% | $806,908 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 80 | Invesco Ltd. | 24.09K | -70.9% | $806,908 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 81 | Fidelity (FMR) ✦ | 23.24K | -0.9% | $778,308 | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 82 | Deutsche Bank Ag\ | 21.87K | +29.9% | $732,527 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 83 | Deutsche Bank Ag\ | 21.87K | +29.9% | $732,527 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 84 | Alliancebernstein L.P. | 29.90K | +52.5% | $718,497 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 85 | Squarepoint Ops LLC | 21.22K | +17.3% | $710,624 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 86 | Swiss National Bank | 19.80K | -10.4% | $663,102 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 87 | Wells Fargo & Company/Mn | 19.68K | +99.5% | $659,218 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 88 | Wells Fargo & Company/Mn | 19.68K | +99.5% | $659,218 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 89 | Franklin Resources Inc | 18.61K | New | $623,148 | 0.0% | New | 1 | SEC ↗ |
| 90 | Franklin Resources Inc | 18.61K | New | $623,148 | 0.0% | New | 1 | SEC ↗ |
| 91 | Citigroup Inc | 17.81K | +93.7% | $596,390 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 92 | Citigroup Inc | 17.81K | +93.7% | $596,390 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 93 | Bnp Paribas Financial Markets | 16.95K | +216.1% | $567,522 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 94 | AQR Capital Management ✦ | 15.40K | +0.1% | $515,646 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 95 | AQR Capital Management ✦ | 15.40K | +0.1% | $515,646 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 96 | AQR Capital Management ✦ | 15.40K | +0.1% | $515,646 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 97 | AQR Capital Management ✦ | 15.40K | +0.1% | $515,646 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 98 | Osaic Holdings, Inc. | 12.59K | -0.8% | $421,772 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 99 | Osaic Holdings, Inc. | 12.59K | -0.8% | $421,772 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 100 | Man Group plc | 11.47K | -3.3% | $384,097 | 0.0% | ▼ Trim | 2 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| Loomis Sayles & Co L P | $20.92M | 0.0% |
| Loomis Sayles & Co L P | $20.92M | 0.0% |
| Lazard Asset Management Llc | $2.53M | 0.0% |
| Dimensional Fund Advisors Lp | $2.52M | 0.0% |
| Dimensional Fund Advisors Lp | $2.52M | 0.0% |
| Dimensional Fund Advisors Lp | $2.52M | 0.0% |
| Dimensional Fund Advisors Lp | $2.52M | 0.0% |
| Arrowstreet Capital | $2.50M | 0.0% |
| D. E. Shaw & Co. | $1.56M | 0.0% |
| Jane Street Group, Llc | $1.53M | 0.0% |
| Jane Street Group, Llc | $1.53M | 0.0% |
| Hrt Financial Lp | $1.41M | 0.0% |
Exited
| Marshall Wace | $957,354 | was 0.0% |
| Adage Capital Partners | $576,720 | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 123 holders, 45.64M shares, $1.09B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Aug 12
RA CAPITAL MANAGEMENT, L.P.
Director, 10% owner · 746.50K sh · $31.73M
Aug 12
RA CAPITAL MANAGEMENT, L.P.
Director, 10% owner · 746.50K sh · $31.73M
Aug 12
Third Rock Ventures V, L.P.
10% owner · 147.06K sh · $7.39M
Aug 12
Third Rock Ventures V, L.P.
10% owner · 141 sh · $7,202
Aug 11
Bhatt Elizabeth
Officer · 25.00K sh · $1.10M
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Aug 14
SC 13G/A — DRIEHAUS CAPITAL MANAGEMENT LLC
Aug 14
SC 13D/A — RA CAPITAL MANAGEMENT, L.P.
11.8% of class · View original SEC filing ↗
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q2 2026 ·
Methodology ·
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