SEPN
Septerna Inc · Healthcare · Biotechnology
Momentum inputs (comparable managers):
holder breadth +8.2% ·
share flow +30.0% ·
net new positions +7.5%
· formula
Broad accumulation: rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Goldman Sachs Group ✦ | 2.72M | +86.6% | $75.70M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 2 | BlackRock ✦ (passive) | 1.80M | +23.4% | $50.22M | 0.0% | ▲ Add | 3 | SEC ↗ ×8 |
| 3 | The Vanguard Group ✦ (passive) | 1.51M | -0.7% | $42.05M | 0.0% | ▼ Trim | 3 | SEC ↗ ×3 |
| 4 | Geode Capital Management ✦ (passive) | 572.73K | +5.0% | $15.97M | 0.0% | ▲ Add | 5 | SEC ↗ ×2 |
| 5 | PRIMECAP Management ✦ | 546.10K | New | $15.23M | 0.0% | New | 1 | SEC ↗ |
| 6 | State Street Global Advisors ✦ (passive) | 540.03K | +28.9% | $15.06M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 7 | Marshall Wace ✦ | 226.90K | New | $6.33M | 0.0% | New | 1 | SEC ↗ ×2 |
| 8 | Universal- Beteiligungs- und… | 222.70K | n/a | $6.21M | 0.0% | n/c | 1 | SEC ↗ |
| 9 | Charles Schwab Investment… | 187.24K | n/a | $5.22M | 0.0% | n/c | 1 | SEC ↗ |
| 10 | Invesco Ltd. | 162.01K | n/a | $4.52M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 11 | Northern Trust Corp | 154.20K | n/a | $4.30M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 12 | Millennium Management ✦ | 107.46K | -72.0% | $3.00M | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 13 | Morgan Stanley ✦ | 103.98K | +91.0% | $2.90M | 0.0% | ▲ Add | 2 | SEC ↗ ×6 |
| 14 | Two Sigma Investments ✦ | 92.81K | +0.5% | $2.59M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 15 | Federated Hermes, Inc. | 78.91K | n/a | $2.20M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 16 | Citadel Advisors ✦ | 75.94K | New | $2.12M | 0.0% | New | 1 | SEC ↗ ×2 |
| 17 | UBS Group AG | 68.82K | n/a | $1.92M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 18 | JPMorgan Chase ✦ | 68.34K | +291.1% | $1.91M | 0.0% | ▲ Add | 2 | SEC ↗ ×3 |
| 19 | Bank of New York Mellon Corp | 55.33K | n/a | $1.54M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 20 | American Century Companies Inc | 50.69K | n/a | $1.41M | 0.0% | n/c | 1 | SEC ↗ |
| 21 | Jane Street Group, Llc | 44.07K | n/a | $1.23M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 22 | Barclays Plc | 38.15K | n/a | $1.06M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 23 | Bank Of America Corp /De/ | 37.59K | n/a | $1.05M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 24 | Alyeska Investment Group, L.P. | 35.00K | n/a | $975,800 | 0.0% | n/c | 1 | SEC ↗ |
| 25 | Wells Fargo & Company/Mn | 26.53K | n/a | $739,628 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 26 | Rhumbline Advisers | 26.42K | n/a | $736,552 | 0.0% | n/c | 1 | SEC ↗ |
| 27 | Nuveen, LLC | 25.80K | n/a | $719,248 | 0.0% | n/c | 1 | SEC ↗ |
| 28 | T. Rowe Price ✦ | 25.44K | -7.2% | $710,000 | 0.0% | ▼ Trim | 5 | SEC ↗ |
| 29 | Alliancebernstein L.P. | 19.60K | n/a | $546,448 | 0.0% | n/c | 1 | SEC ↗ |
| 30 | Tudor Investment Corp Et Al | 18.05K | n/a | $503,318 | 0.0% | n/c | 1 | SEC ↗ |
| 31 | Franklin Resources Inc | 16.85K | n/a | $469,834 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 32 | Russell Investments Group, Ltd. | 15.31K | n/a | $426,840 | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 33 | Deutsche Bank Ag\ | 14.88K | n/a | $414,827 | 0.0% | n/c | 1 | SEC ↗ |
| 34 | Squarepoint Ops LLC | 14.85K | n/a | $413,934 | 0.0% | n/c | 1 | SEC ↗ |
| 35 | Ameriprise Financial Inc | 14.09K | n/a | $392,829 | 0.0% | n/c | 1 | SEC ↗ |
| 36 | Osaic Holdings, Inc. | 12.69K | n/a | $353,880 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 37 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 9.93K | n/a | $276,960 | 0.0% | n/c | 1 | SEC ↗ |
| 38 | Citigroup Inc | 9.56K | n/a | $266,561 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 39 | Bank Of Nova Scotia | 8.30K | n/a | $231,404 | 0.0% | n/c | 1 | SEC ↗ |
| 40 | AQR Capital Management ✦ | 7.83K | New | $218,189 | 0.0% | New | 1 | SEC ↗ ×5 |
| 41 | New York State Common Retirement… | 5.60K | n/a | $156,128 | 0.0% | n/c | 1 | SEC ↗ |
| 42 | Bnp Paribas Financial Markets | 5.45K | n/a | $151,918 | 0.0% | n/c | 1 | SEC ↗ |
| 43 | Balyasny Asset Management L.P. | 3.57K | n/a | $99,559 | 0.0% | n/c | 1 | SEC ↗ |
| 44 | Fidelity (FMR) ✦ | 3.31K | -3.8% | $92,199 | 0.0% | ▼ Trim | 3 | SEC ↗ |
| 45 | Mirae Asset Global Investments Co.… | 2.18K | n/a | $60,667 | 0.0% | n/c | 1 | SEC ↗ |
| 46 | Legal & General Group Plc | 1.95K | n/a | $54,168 | 0.0% | n/c | 1 | SEC ↗ |
| 47 | California State Teachers… | 1.32K | n/a | $36,690 | 0.0% | n/c | 1 | SEC ↗ |
| 48 | Group One Trading Llc | 944 | n/a | $26,319 | 0.0% | n/c | 1 | SEC ↗ |
| 49 | Cwm, Llc | 888 | n/a | $25,000 | 0.0% | n/c | 1 | SEC ↗ |
| 50 | Royal Bank Of Canada | 628 | n/a | $18,000 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 51 | Pnc Financial Services Group, Inc. | 198 | n/a | $5,520 | 0.0% | n/c | 1 | SEC ↗ |
| 52 | Us Bancorp \De\ | 190 | n/a | $5,297 | 0.0% | n/c | 1 | SEC ↗ |
| 53 | Daiwa Securities Group Inc. | 149 | n/a | $4,000 | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| PRIMECAP Management | $15.23M | 0.0% |
| Marshall Wace | $6.33M | 0.0% |
| Citadel Advisors | $2.12M | 0.0% |
| AQR Capital Management | $218,189 | 0.0% |
Exited
| No tracked exits this quarter. |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 123 holders, 45.64M shares, $1.09B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Officer · 2.91K sh · $109,307
Officer · 1.09K sh · $40,337
10% owner · 141 sh · $7,202
Director, 10% owner · 746.50K sh · $31.73M
Director, 10% owner · 746.50K sh · $31.73M
10% owner · 147.06K sh · $7.39M
Officer · 25.00K sh · $1.10M
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
11.8% of class · View original SEC filing ↗