SEPN
Septerna Inc · Healthcare · Biotechnology
Momentum inputs (comparable managers):
holder breadth +12.5% ·
share flow -6.3% ·
net new positions +11.1%
— formula
Ownership fragmentation — more holders, smaller aggregate stake
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q2 2025
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 69 | +20 | 12.16M | $407.03M | +22 | −2 |
| Q1 2026 | 52 | -1 | 11.23M | $269.91M | +8 | −9 |
| Q4 2025 | 53 | +4 | 9.79M | $272.84M | +4 | — |
| Q3 2025 | 11 | -1 | 5.98M | $112.43M | — | −1 |
| Q2 2025 | 9 | +1 | 3.84M | $40.57M | +1 | — |
| Q1 2025 | 5 | -1 | 1.29M | $7.46M | +2 | −3 |
| Q4 2024 | 6 | +5 | 1.89M | $43.21M | +5 | — |
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | The Vanguard Group ✦ (passive) | 1.41M | — | $14.95M | 0.0% | n/c | 1 | SEC ↗ |
| 2 | The Vanguard Group ✦ (passive) | 1.41M | — | $14.95M | 0.0% | n/c | 1 | SEC ↗ |
| 3 | The Vanguard Group ✦ (passive) | 1.41M | — | $14.95M | 0.0% | n/c | 1 | SEC ↗ |
| 4 | BlackRock ✦ (passive) | 1.39M | — | $14.70M | 0.0% | n/c | 1 | SEC ↗ |
| 5 | BlackRock ✦ (passive) | 1.39M | — | $14.70M | 0.0% | n/c | 1 | SEC ↗ |
| 6 | BlackRock ✦ (passive) | 1.39M | — | $14.70M | 0.0% | n/c | 1 | SEC ↗ |
| 7 | BlackRock ✦ (passive) | 1.39M | — | $14.70M | 0.0% | n/c | 1 | SEC ↗ |
| 8 | BlackRock ✦ (passive) | 1.39M | — | $14.70M | 0.0% | n/c | 1 | SEC ↗ |
| 9 | BlackRock ✦ (passive) | 1.39M | — | $14.70M | 0.0% | n/c | 1 | SEC ↗ |
| 10 | BlackRock ✦ (passive) | 1.39M | — | $14.70M | 0.0% | n/c | 1 | SEC ↗ |
| 11 | Geode Capital Management ✦ (passive) | 487.96K | +19.1% | $5.16M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 12 | Geode Capital Management ✦ (passive) | 487.96K | +19.1% | $5.16M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 13 | State Street Global Advisors ✦ (passive) | 369.99K | +7.4% | $3.91M | 0.0% | ▲ Add | 3 | SEC ↗ |
| 14 | Two Sigma Investments ✦ | 77.64K | +3.7% | $820,676 | 0.0% | ▲ Add | 2 | SEC ↗ |
| 15 | Millennium Management ✦ | 51.94K | -88.1% | $549,048 | 0.0% | ▼ Trim | 2 | SEC ↗ |
| 16 | T. Rowe Price ✦ | 24.90K | +8.5% | $264,000 | 0.0% | ▲ Add | 3 | SEC ↗ |
| 17 | Citadel Advisors ✦ | 17.77K | New | $187,871 | 0.0% | New | 1 | SEC ↗ |
| 18 | Citadel Advisors ✦ | 17.77K | New | $187,871 | 0.0% | New | 1 | SEC ↗ |
| 19 | Fidelity (FMR) ✦ | 2.48K | — | $26,266 | 0.0% | n/c | 1 | SEC ↗ |
| 20 | Fidelity (FMR) ✦ | 2.48K | — | $26,266 | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| Citadel Advisors | $187,871 | 0.0% |
| Citadel Advisors | $187,871 | 0.0% |
Exited
| No tracked exits this quarter. |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 123 holders, 45.64M shares, $1.09B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Director, 10% owner · 746.50K sh · $31.73M
Director, 10% owner · 746.50K sh · $31.73M
10% owner · 147.06K sh · $7.39M
10% owner · 141 sh · $7,202
Officer · 25.00K sh · $1.10M
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
11.8% of class · View original SEC filing ↗