Security record · archived quarter
PTGX
Protagonist Therapeutics, Inc. · Healthcare · Biotechnology
107Tracked holders
+4Δ holders
45.87MShares held
$4.01BReported value
+4New positions
−0Exits
Momentum inputs (comparable managers):
holder breadth +3.9% ·
share flow +7.9% ·
net new positions +3.7%
· formula
Broad accumulation: rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q3 2026 | 1 | 0 | 4.85K | $678,004 | n/a | −1 |
| Q2 2026 | 104 | +1 | 45.40M | $5.56B | +7 | −8 |
| Q1 2026 | 108 | -1 | 49.99M | $5.27B | +9 | −10 |
| Q4 2025 | 107 | +4 | 45.87M | $4.01B | +4 | n/a |
| Q3 2025 | 17 | 0 | 26.31M | $1.75B | +2 | −2 |
| Q2 2025 | 14 | -1 | 22.53M | $1.25B | +1 | −2 |
| Q1 2025 | 12 | +1 | 7.51M | $363.26M | +3 | −2 |
| Q4 2024 | 11 | -2 | 7.82M | $302.00M | n/a | −2 |
| Q3 2024 | 12 | +2 | 4.92M | $221.52M | +3 | −1 |
| Q2 2024 | 10 | n/a | 7.44M | $257.83M | n/a | n/a |
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | BlackRock ✦ (passive) | 9.72M | +3.3% | $848.60M | 0.0% | ▲ Add | 3 | SEC ↗ ×18 |
| 2 | The Vanguard Group ✦ (passive) | 5.41M | +27.2% | $472.83M | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 3 | State Street Global Advisors ✦ (passive) | 3.20M | +1.1% | $279.46M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 4 | Wellington Management ✦ | 3.17M | +66.2% | $276.99M | 0.0% | ▲ Add | 6 | SEC ↗ ×8 |
| 5 | UBS Group AG | 2.77M | n/a | $241.93M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 6 | Janus Henderson Group Plc | 2.65M | n/a | $231.35M | 0.1% | n/c | 1 | SEC ↗ ×3 |
| 7 | Invesco Ltd. | 1.57M | n/a | $136.94M | 0.0% | n/c | 1 | SEC ↗ ×7 |
| 8 | Geode Capital Management ✦ (passive) | 1.45M | +2.6% | $126.92M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 9 | T. Rowe Price ✦ | 1.40M | +14.8% | $122.34M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 10 | Citadel Advisors ✦ | 1.13M | +373.6% | $98.40M | 0.1% | ▲ Add | 6 | SEC ↗ ×2 |
| 11 | Marshall Wace ✦ | 1.02M | -5.6% | $89.52M | 0.1% | ▼ Trim | 2 | SEC ↗ ×3 |
| 12 | Goldman Sachs Group ✦ | 961.15K | +22.9% | $83.95M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 13 | Morgan Stanley ✦ | 879.02K | +14.4% | $76.77M | 0.0% | ▲ Add | 2 | SEC ↗ ×10 |
| 14 | Bank Of America Corp /De/ | 867.58K | n/a | $75.77M | 0.0% | n/c | 1 | SEC ↗ ×7 |
| 15 | Northern Trust Corp | 575.12K | n/a | $50.23M | 0.0% | n/c | 1 | SEC ↗ ×7 |
| 16 | Charles Schwab Investment… | 556.76K | n/a | $48.63M | 0.0% | n/c | 1 | SEC ↗ |
| 17 | Fidelity (FMR) ✦ | 539.88K | +3.7% | $47.15M | 0.0% | ▲ Add | 3 | SEC ↗ ×2 |
| 18 | American Century Companies Inc | 535.42K | n/a | $46.76M | 0.0% | n/c | 1 | SEC ↗ |
| 19 | Pictet Asset Management Holding SA | 529.63K | n/a | $46.26M | 0.0% | n/c | 1 | SEC ↗ |
| 20 | Clearbridge Investments, LLC | 489.84K | n/a | $42.78M | 0.0% | n/c | 1 | SEC ↗ |
| 21 | Dimensional Fund Advisors Lp | 414.42K | n/a | $36.19M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 22 | Voya Investment Management Llc | 366.17K | n/a | $31.98M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 23 | Bank of New York Mellon Corp | 350.39K | n/a | $30.60M | 0.0% | n/c | 1 | SEC ↗ ×10 |
| 24 | Principal Financial Group Inc | 347.93K | n/a | $30.39M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 25 | Jennison Associates Llc | 331.16K | n/a | $28.92M | 0.0% | n/c | 1 | SEC ↗ |
| 26 | BNP Paribas Asset Management… | 330.80K | n/a | $28.89M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 27 | Adage Capital Partners ✦ | 232.84K | -67.6% | $20.34M | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 28 | Holocene Advisors, LP | 210.02K | n/a | $18.34M | 0.0% | n/c | 1 | SEC ↗ |
| 29 | Alyeska Investment Group, L.P. | 199.52K | n/a | $17.43M | 0.0% | n/c | 1 | SEC ↗ |
| 30 | Barclays Plc | 187.64K | n/a | $16.39M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 31 | Raymond James Financial Inc | 181.50K | n/a | $15.84M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 32 | Ameriprise Financial Inc | 169.52K | n/a | $14.81M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 33 | Duquesne Family Office ✦ | 159.70K | 0.0% | $13.95M | 0.3% | Held | 2 | SEC ↗ |
| 34 | Td Asset Management Inc | 158.73K | n/a | $13.86M | 0.0% | n/c | 1 | SEC ↗ |
| 35 | JPMorgan Chase ✦ | 155.30K | -69.2% | $13.56M | 0.0% | ▼ Trim | 2 | SEC ↗ ×6 |
| 36 | Rhumbline Advisers | 154.95K | n/a | $13.53M | 0.0% | n/c | 1 | SEC ↗ |
| 37 | Qube Research & Technologies Ltd | 153.88K | n/a | $13.44M | 0.0% | n/c | 1 | SEC ↗ |
| 38 | Legal & General Group Plc | 149.16K | n/a | $13.03M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 39 | Nuveen, LLC | 125.86K | n/a | $10.99M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 40 | Universal- Beteiligungs- und… | 114.04K | n/a | $9.96M | 0.0% | n/c | 1 | SEC ↗ |
| 41 | Manufacturers Life Insurance… | 113.34K | n/a | $9.89M | 0.0% | n/c | 1 | SEC ↗ |
| 42 | Prudential Financial Inc | 110.36K | n/a | $9.64M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 43 | Deutsche Bank Ag\ | 105.46K | n/a | $9.21M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 44 | UBS AM, a distinct business unit of… | 104.53K | n/a | $9.13M | 0.0% | n/c | 1 | SEC ↗ ×9 |
| 45 | Soros Fund Management ✦ | 100.00K | New | $8.73M | 0.2% | New | 1 | SEC ↗ |
| 46 | Neuberger Berman Group LLC | 98.47K | n/a | $8.60M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 47 | Swiss National Bank | 98.20K | n/a | $8.58M | 0.0% | n/c | 1 | SEC ↗ |
| 48 | Bnp Paribas Financial Markets | 97.76K | n/a | $8.54M | 0.0% | n/c | 1 | SEC ↗ |
| 49 | Citigroup Inc | 94.91K | n/a | $8.29M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 50 | Victory Capital Management Inc | 80.57K | n/a | $7.04M | 0.0% | n/c | 1 | SEC ↗ |
| 51 | Franklin Resources Inc | 76.44K | n/a | $6.68M | 0.0% | n/c | 1 | SEC ↗ ×7 |
| 52 | Alliancebernstein L.P. | 73.22K | n/a | $6.40M | 0.0% | n/c | 1 | SEC ↗ |
| 53 | Wells Fargo & Company/Mn | 71.64K | n/a | $6.26M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 54 | Fisher Asset Management ✦ | 65.11K | New | $5.69M | 0.0% | New | 1 | SEC ↗ |
| 55 | Northwestern Mutual Wealth… | 48.89K | n/a | $4.27M | 0.0% | n/c | 1 | SEC ↗ |
| 56 | California State Teachers… | 48.03K | n/a | $4.20M | 0.0% | n/c | 1 | SEC ↗ |
| 57 | First Trust Advisors Lp | 46.45K | n/a | $4.06M | 0.0% | n/c | 1 | SEC ↗ |
| 58 | Creative Planning | 41.25K | n/a | $3.60M | 0.0% | n/c | 1 | SEC ↗ |
| 59 | LMR Partners LLP | 40.00K | n/a | $3.49M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 60 | Sei Investments Co | 37.35K | n/a | $3.26M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 61 | State Of Wisconsin Investment Board | 34.79K | n/a | $3.04M | 0.0% | n/c | 1 | SEC ↗ |
| 62 | Jane Street Group, Llc | 34.31K | n/a | $3.00M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 63 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 30.79K | n/a | $2.69M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 64 | Gotham Asset Management ✦ | 21.59K | -2.7% | $1.89M | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 65 | New York State Common Retirement… | 18.38K | n/a | $1.61M | 0.0% | n/c | 1 | SEC ↗ |
| 66 | Nomura Holdings Inc | 17.52K | n/a | $1.53M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 67 | Millennium Management ✦ | 17.39K | -86.4% | $1.52M | 0.0% | ▼ Trim | 4 | SEC ↗ |
| 68 | State Board Of Administration Of… | 16.30K | n/a | $1.42M | 0.0% | n/c | 1 | SEC ↗ |
| 69 | Envestnet Asset Management Inc | 14.67K | n/a | $1.28M | 0.0% | n/c | 1 | SEC ↗ |
| 70 | ProShare Advisors LLC | 14.08K | n/a | $1.23M | 0.0% | n/c | 1 | SEC ↗ |
| 71 | Connor, Clark & Lunn Investment… | 13.27K | n/a | $1.16M | 0.0% | n/c | 1 | SEC ↗ |
| 72 | Allianz Asset Management GmbH | 13.00K | n/a | $1.14M | 0.0% | n/c | 1 | SEC ↗ |
| 73 | Susquehanna International Group, Llp | 11.76K | n/a | $1.03M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 74 | Zurcher Kantonalbank (Zurich… | 10.07K | n/a | $879,776 | 0.0% | n/c | 1 | SEC ↗ |
| 75 | Cerity Partners LLC | 9.05K | n/a | $790,339 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 76 | Bamco Inc /Ny/ | 8.30K | n/a | $724,922 | 0.0% | n/c | 1 | SEC ↗ |
| 77 | Renaissance Technologies ✦ | 8.17K | New | $713,306 | 0.0% | New | 1 | SEC ↗ |
| 78 | Tudor Investment Corp Et Al | 7.72K | n/a | $674,090 | 0.0% | n/c | 1 | SEC ↗ |
| 79 | Mariner, LLC | 7.62K | n/a | $665,641 | 0.0% | n/c | 1 | SEC ↗ |
| 80 | HighTower Advisors, LLC | 7.13K | n/a | $622,472 | 0.0% | n/c | 1 | SEC ↗ |
| 81 | AQR Capital Management ✦ | 6.95K | -18.9% | $607,362 | 0.0% | ▼ Trim | 7 | SEC ↗ ×5 |
| 82 | Russell Investments Group, Ltd. | 5.72K | n/a | $499,845 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 83 | Aviva Plc | 5.61K | n/a | $489,890 | 0.0% | n/c | 1 | SEC ↗ |
| 84 | Arrowstreet Capital ✦ | 5.08K | New | $443,338 | 0.0% | New | 1 | SEC ↗ |
| 85 | Quantinno Capital Management LP | 4.95K | n/a | $432,158 | 0.0% | n/c | 1 | SEC ↗ |
| 86 | Ensign Peak Advisors, Inc | 4.49K | n/a | $391,807 | 0.0% | n/c | 1 | SEC ↗ |
| 87 | Us Bancorp \De\ | 4.39K | n/a | $383,858 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 88 | Osaic Holdings, Inc. | 4.20K | n/a | $366,895 | 0.0% | n/c | 1 | SEC ↗ |
| 89 | Allspring Global Investments… | 3.98K | n/a | $347,412 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 90 | Bank Of Montreal /Can/ | 3.81K | n/a | $332,286 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 91 | Mackenzie Financial Corp | 3.65K | n/a | $317,698 | 0.0% | n/c | 1 | SEC ↗ |
| 92 | Wealth Enhancement Advisory… | 3.55K | n/a | $292,386 | 0.0% | n/c | 1 | SEC ↗ |
| 93 | Rockefeller Capital Management L.P. | 3.29K | n/a | $287,524 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 94 | LPL Financial LLC | 3.27K | n/a | $285,165 | 0.0% | n/c | 1 | SEC ↗ |
| 95 | Royal Bank Of Canada | 3.18K | n/a | $278,000 | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 96 | Mirae Asset Global Investments Co.… | 3.04K | n/a | $265,339 | 0.0% | n/c | 1 | SEC ↗ |
| 97 | Pnc Financial Services Group, Inc. | 2.96K | n/a | $258,439 | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 98 | Captrust Financial Advisors | 2.73K | n/a | $238,613 | 0.0% | n/c | 1 | SEC ↗ |
| 99 | CIBC Asset Management Inc | 2.67K | n/a | $232,936 | 0.0% | n/c | 1 | SEC ↗ |
| 100 | Sumitomo Mitsui Trust Group, Inc. | 2.56K | n/a | $223,590 | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value: the conviction measure. ✦ = curated manager.
New buyers
| Soros Fund Management | $8.73M | 0.2% |
| Fisher Asset Management | $5.69M | 0.0% |
| Renaissance Technologies | $713,306 | 0.0% |
| Arrowstreet Capital | $443,338 | 0.0% |
Exited
| No tracked exits this quarter. |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 310 holders, 71.79M shares, $7.31B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold: shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Sep 30
Ali Asif
Officer · 46.03K sh · $6.53M
Sep 30
Ali Asif
Officer · 12.60K sh · $1.79M
Sep 10
PATEL DINESH V PH D
Officer, Director · 7.28K sh · $1.05M
Sep 09
PATEL DINESH V PH D
Officer, Director · 63.55K sh · $9.29M
Sep 08
PATEL DINESH V PH D
Officer, Director · 54.17K sh · $7.90M
Aug 11
PATEL DINESH V PH D
Officer, Director · 34.24K sh · $5.09M
Aug 10
PATEL DINESH V PH D
Officer, Director · 65.76K sh · $9.81M
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Aug 13
SC 13G/A: FARALLON CAPITAL MANAGEMENT, L.L.C.
Aug 07
SC 13G: STATE STREET CORP
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
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