Security record · archived quarter
MLYS
Mineralys Therapeutics, Inc. · Healthcare · Biotechnology
84Tracked holders
+1Δ holders
40.64MShares held
$1.47BReported value
+2New positions
−1Exits
Momentum inputs (comparable managers):
holder breadth +1.2% ·
share flow +17.3% ·
net new positions +1.2%
— formula
Broad accumulation — rising shares across more holders
All ownership figures: tracked 13F managers only, common-stock positions, reporting period Q4 2025
Ownership over time
| Quarter | Holders | Δ | Shares | Reported value | New | Exits |
|---|---|---|---|---|---|---|
| Q2 2026 | 86 | +2 | 43.69M | $1.18B | +8 | −6 |
| Q1 2026 | 87 | +2 | 39.40M | $1.08B | +7 | −5 |
| Q4 2025 | 84 | +1 | 40.64M | $1.47B | +2 | −1 |
| Q3 2025 | 17 | +2 | 19.50M | $739.53M | +2 | — |
| Q2 2025 | 12 | -1 | 9.30M | $125.82M | — | −1 |
| Q1 2025 | 10 | +4 | 2.76M | $43.90M | +4 | — |
| Q4 2024 | 6 | 0 | 2.45M | $30.15M | +1 | −1 |
| Q3 2024 | 5 | 0 | 890.52K | $10.79M | +1 | −1 |
| Q2 2024 | 5 | — | 738.83K | $8.65M | — | — |
Who holds it · Q4 2025
| # | Manager | Shares | Δ shares | Value | Their weight | Held | ||
|---|---|---|---|---|---|---|---|---|
| 1 | Fidelity (FMR) ✦ | 5.06M | +144.2% | $183.54M | 0.0% | ▲ Add | 3 | SEC ↗ ×4 |
| 2 | BlackRock ✦ (passive) | 4.33M | +17.9% | $157.05M | 0.0% | ▲ Add | 3 | SEC ↗ ×13 |
| 3 | The Vanguard Group ✦ (passive) | 3.35M | +11.1% | $121.68M | 0.0% | ▲ Add | 3 | SEC ↗ ×5 |
| 4 | State Street Global Advisors ✦ (passive) | 3.18M | +144.4% | $115.58M | 0.0% | ▲ Add | 5 | SEC ↗ |
| 5 | Franklin Resources Inc | 1.79M | — | $64.91M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 6 | Holocene Advisors, LP | 1.60M | — | $58.14M | 0.1% | n/c | 1 | SEC ↗ |
| 7 | Goldman Sachs Group ✦ | 1.45M | +103.9% | $52.65M | 0.0% | ▲ Add | 2 | SEC ↗ ×2 |
| 8 | T. Rowe Price ✦ | 1.33M | +6097.1% | $48.09M | 0.0% | ▲ Add | 5 | SEC ↗ ×2 |
| 9 | Jennison Associates Llc | 1.26M | — | $45.68M | 0.0% | n/c | 1 | SEC ↗ |
| 10 | Geode Capital Management ✦ (passive) | 1.26M | +11.9% | $45.64M | 0.0% | ▲ Add | 7 | SEC ↗ ×2 |
| 11 | Janus Henderson Group Plc | 1.21M | — | $44.01M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 12 | Point72 Asset Management ✦ | 1.21M | -32.9% | $43.81M | 0.1% | ▼ Trim | 2 | SEC ↗ |
| 13 | Capital International Investors | 1.16M | — | $42.22M | 0.0% | n/c | 1 | SEC ↗ |
| 14 | D. E. Shaw & Co. ✦ | 1.15M | +88.3% | $41.76M | 0.0% | ▲ Add | 4 | SEC ↗ |
| 15 | Bank Of America Corp /De/ | 987.28K | — | $35.83M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 16 | Alliancebernstein L.P. | 922.52K | — | $33.48M | 0.0% | n/c | 1 | SEC ↗ |
| 17 | American Century Companies Inc | 908.09K | — | $32.95M | 0.0% | n/c | 1 | SEC ↗ |
| 18 | Pictet Asset Management Holding SA | 852.88K | — | $30.95M | 0.0% | n/c | 1 | SEC ↗ |
| 19 | Wellington Management ✦ | 784.27K | +0.1% | $28.46M | 0.0% | ▲ Add | 6 | SEC ↗ ×7 |
| 20 | Morgan Stanley ✦ | 639.51K | -53.6% | $23.21M | 0.0% | ▼ Trim | 2 | SEC ↗ ×9 |
| 21 | Two Sigma Investments ✦ | 610.40K | New | $22.15M | 0.0% | New | 1 | SEC ↗ |
| 22 | Qube Research & Technologies Ltd | 496.55K | — | $18.02M | 0.0% | n/c | 1 | SEC ↗ |
| 23 | Charles Schwab Investment… | 461.30K | — | $16.74M | 0.0% | n/c | 1 | SEC ↗ |
| 24 | Citadel Advisors ✦ | 399.92K | -80.7% | $14.51M | 0.0% | ▼ Trim | 4 | SEC ↗ ×2 |
| 25 | Renaissance Technologies ✦ | 322.10K | +579.5% | $11.69M | 0.0% | ▲ Add | 7 | SEC ↗ |
| 26 | Northern Trust Corp | 299.86K | — | $10.88M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 27 | Marshall Wace ✦ | 249.13K | New | $9.04M | 0.0% | New | 1 | SEC ↗ ×2 |
| 28 | Squarepoint Ops LLC | 246.80K | — | $8.96M | 0.0% | n/c | 1 | SEC ↗ |
| 29 | Barclays Plc | 223.28K | — | $8.10M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 30 | Swedbank AB | 221.40K | — | $8.03M | 0.0% | n/c | 1 | SEC ↗ |
| 31 | UBS Group AG | 201.28K | — | $7.30M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 32 | Russell Investments Group, Ltd. | 175.36K | — | $6.36M | 0.0% | n/c | 1 | SEC ↗ ×5 |
| 33 | Bnp Paribas Financial Markets | 172.93K | — | $6.28M | 0.0% | n/c | 1 | SEC ↗ |
| 34 | Susquehanna International Group, Llp | 143.21K | — | $5.20M | 0.0% | n/c | 1 | SEC ↗ |
| 35 | Dimensional Fund Advisors Lp | 137.64K | — | $4.99M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 36 | Bank of New York Mellon Corp | 131.84K | — | $4.78M | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 37 | Nuveen, LLC | 122.95K | — | $4.46M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 38 | Voya Investment Management Llc | 112.67K | — | $4.09M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 39 | Ensign Peak Advisors, Inc | 112.19K | — | $4.07M | 0.0% | n/c | 1 | SEC ↗ |
| 40 | DZ BANK AG Deutsche Zentral… | 111.75K | — | $4.06M | 0.0% | n/c | 1 | SEC ↗ |
| 41 | Swiss National Bank | 90.10K | — | $3.27M | 0.0% | n/c | 1 | SEC ↗ |
| 42 | Prudential Financial Inc | 89.06K | — | $3.23M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 43 | Hrt Financial Lp | 87.24K | — | $3.17M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 44 | Millennium Management ✦ | 78.62K | -80.6% | $2.85M | 0.0% | ▼ Trim | 7 | SEC ↗ |
| 45 | UBS AM, a distinct business unit of… | 75.90K | — | $2.75M | 0.0% | n/c | 1 | SEC ↗ ×6 |
| 46 | AQR Capital Management ✦ | 62.30K | +243.8% | $2.26M | 0.0% | ▲ Add | 4 | SEC ↗ ×6 |
| 47 | Wells Fargo & Company/Mn | 56.76K | — | $2.06M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 48 | Rhumbline Advisers | 54.28K | — | $1.97M | 0.0% | n/c | 1 | SEC ↗ |
| 49 | State Of Wisconsin Investment Board | 49.94K | — | $1.81M | 0.0% | n/c | 1 | SEC ↗ |
| 50 | JPMorgan Chase ✦ | 46.68K | -87.3% | $1.69M | 0.0% | ▼ Trim | 2 | SEC ↗ ×4 |
| 51 | Ameriprise Financial Inc | 46.25K | — | $1.68M | 0.0% | n/c | 1 | SEC ↗ |
| 52 | Legal & General Group Plc | 43.94K | — | $1.59M | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 53 | California State Teachers… | 43.35K | — | $1.57M | 0.0% | n/c | 1 | SEC ↗ |
| 54 | Tudor Investment Corp Et Al | 39.05K | — | $1.42M | 0.0% | n/c | 1 | SEC ↗ |
| 55 | Deutsche Bank Ag\ | 37.24K | — | $1.35M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 56 | Victory Capital Management Inc | 32.88K | — | $1.19M | 0.0% | n/c | 1 | SEC ↗ |
| 57 | Allianz Asset Management GmbH | 30.20K | — | $1.10M | 0.0% | n/c | 1 | SEC ↗ |
| 58 | Canada Pension Plan Investment Board | 29.60K | — | $1.07M | 0.0% | n/c | 1 | SEC ↗ |
| 59 | Invesco Ltd. | 29.14K | — | $1.06M | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 60 | MIRAE ASSET GLOBAL ETFS HOLDINGS… | 29.18K | — | $1.05M | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 61 | Raymond James Financial Inc | 24.97K | — | $906,306 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 62 | Creative Planning | 21.10K | — | $765,828 | 0.0% | n/c | 1 | SEC ↗ |
| 63 | Citigroup Inc | 18.32K | — | $664,651 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 64 | Quantinno Capital Management LP | 18.24K | — | $662,038 | 0.0% | n/c | 1 | SEC ↗ |
| 65 | Zurcher Kantonalbank (Zurich… | 17.35K | — | $629,559 | 0.0% | n/c | 1 | SEC ↗ |
| 66 | Manufacturers Life Insurance… | 16.18K | — | $587,208 | 0.0% | n/c | 1 | SEC ↗ |
| 67 | New York State Common Retirement… | 12.56K | — | $455,948 | 0.0% | n/c | 1 | SEC ↗ |
| 68 | ProShare Advisors LLC | 12.04K | — | $436,932 | 0.0% | n/c | 1 | SEC ↗ |
| 69 | Universal- Beteiligungs- und… | 12.00K | — | $435,371 | 0.0% | n/c | 1 | SEC ↗ |
| 70 | Mariner, LLC | 10.23K | — | $371,452 | 0.0% | n/c | 1 | SEC ↗ |
| 71 | Sei Investments Co | 8.78K | — | $318,624 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 72 | State Board Of Administration Of… | 7.56K | — | $274,389 | 0.0% | n/c | 1 | SEC ↗ |
| 73 | Connor, Clark & Lunn Investment… | 6.86K | — | $248,949 | 0.0% | n/c | 1 | SEC ↗ |
| 74 | Cwm, Llc | 5.10K | — | $185,000 | 0.0% | n/c | 1 | SEC ↗ |
| 75 | Simplex Trading, Llc | 4.80K | — | $174,264 | 0.0% | n/c | 1 | SEC ↗ |
| 76 | Mirae Asset Global Investments Co.… | 3.85K | — | $139,571 | 0.0% | n/c | 1 | SEC ↗ |
| 77 | Pnc Financial Services Group, Inc. | 2.23K | — | $81,072 | 0.0% | n/c | 1 | SEC ↗ ×3 |
| 78 | Royal Bank Of Canada | 1.53K | — | $56,000 | 0.0% | n/c | 1 | SEC ↗ ×4 |
| 79 | Osaic Holdings, Inc. | 1.16K | — | $41,915 | 0.0% | n/c | 1 | SEC ↗ |
| 80 | Daiwa Securities Group Inc. | 235 | — | $9,000 | 0.0% | n/c | 1 | SEC ↗ |
| 81 | Rockefeller Capital Management L.P. | 134 | — | $4,863 | 0.0% | n/c | 1 | SEC ↗ ×2 |
| 82 | Us Bancorp \De\ | 81 | — | $2,939 | 0.0% | n/c | 1 | SEC ↗ |
| 83 | Optiver Holding B.V. | 42 | — | $1,524 | 0.0% | n/c | 1 | SEC ↗ |
| 84 | Nomura Asset Management Co Ltd | 0 | — | $0 | 0.0% | n/c | 1 | SEC ↗ |
“Their weight” = the position's share of that manager's reported 13F equity value — the conviction measure. ✦ = curated manager.
New buyers
| Two Sigma Investments | $22.15M | 0.0% |
| Marshall Wace | $9.04M | 0.0% |
Exited
| Adage Capital Partners | $3.98M | was 0.0% |
Full-market context: across ALL 13F filers (SEC structured data, Q1 2026): 213 holders, 90.27M shares, $2.39B reported. This is a different, older period than the tracked-universe figures above and the two are never mixed.
Frequently co-owned
What else this security's tracked holders most often hold — shared-ownership counts, not fundamental relationships.
Open-market purchases (P)
No open-market insider purchases in our coverage window.
Open-market sales (S)
Sep 30
Congleton Jon
Officer, Director · 75.00K sh · $1.91M
Sep 22
Slingsby Brian Taylor
Director · 104.32K sh · $3.01M
Sep 21
Warren Eric
Officer · 7.44K sh · $209,136
Sep 15
Karydas Daphne
Director · 3.00K sh · $85,740
Aug 21
Warren Eric
Officer · 7.44K sh · $193,189
Aug 10
Rodman David Malcom
Officer · 2.17K sh · $58,785
Awards, exercises and tax withholding are never counted as buys or sales here. Methodology
Aug 06
SC 13G/A — FMR LLC
Provenance: Ownership from parsed 13F common-stock positions (tracked universe, comparable sets for changes); insider rows from Forms 3/4/5; stakes from Schedules 13D/13G; every filing links to its original on SEC EDGAR.
Reporting period: Q4 2025 ·
Methodology ·
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